Kinetics of the release of antibiotics from chitosan-based biodegradable biopolymer membranes

Sevostyanov, M. A.; Fedotov, A. Yu.; Nasakina, E. O.; Teterina, A. Yu.; Баикин, А. С.; Sergienko, K. V.; Колмаков, А. Г.; Komlev, V. S.; Иванов, В. Э.; Karp, O. E.; Gudkov, Sergey V.; Баринов, С. М.

doi:10.1134/s001250081511004x

Cited by 20 publications

(7 citation statements)

References 9 publications

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“…ХИМИЧЕСКИЕ НАУКИ (02.00.00) спектроскопии в видимой и ультрафио-летовой части спектра [9]. Измерения проводили в кварцевых кюветах с дли-ной оптического пути 1 см при помощи спектрофотометра Cary 100 (Varian, Ав-стралия) [3].…”

Section: успехи современного естествознания № 12 2016unclassified

“…Данный подход позво-ляет учесть влияние хитозана, который хоть и плохо, но также частично раство-ряется в водных растворах. Для контроля растворения хитозана высой плотности использовали сравнение раствора, образу-ющегося над хитозановой мембраной, не содержащей антибиотик, и изначального раствора, в котором проходила экстракция веществ из мембран [9]. Для моменталь-ных количественных оценок высвобож-дения антибиотика из мембран на основе хитозана высокой плотности было необхо-димо определить коэффициенты молярно-го поглощения линкомицина (рис.…”

Section: успехи современного естествознания № 12 2016unclassified

“…должны быть атравматичными, биосовместимыми, биодеградируемыми. Перспективным мате-риалом для получения систем с контроли-руемой доставкой фармацевтических пре-паратов является хитозан [9].…”

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“…В дан-ной статье будет рассмотрено решение про-блемы связанной с наличием кислоты в со-ставе хитозана. Кроме того, хитозан может частично связывать жирорастворимые со-единения за счет эффекта молекулярного сита и гидрофобных взаимодействий [9]. Для хитозана характерны мукоадгезивные свойства, то есть способность к прилипа-нию к слизистым оболочкам.…”

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The Kinetics of Lincomycin Release From Biopolymer Biodegradable of Membranes Based on High Density Chitosan

Sevostyanov¹,

Nasakina²,

Баикин³

et al. 2016

УСЕ (ACNR)

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Section: успехи современного естествознания № 12 2016unclassified

unclassified

See 2 more Smart Citations

The Kinetics of Lincomycin Release From Biopolymer Biodegradable of Membranes Based on High Density Chitosan

Sevostyanov¹,

Nasakina²,

Баикин³

et al. 2016

УСЕ (ACNR)

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“…And increasingly, multicomponent materials are being created now to improve and combine various functional properties. In particular, the creation of a composite material with a surface layer of a biodegradable biopolymer on the basis of an alloy with an SME will provide medical products with the possibility of local therapeutic effects through controlled release of drugs for a given time [13][14][15]. By correctly choosing a biodegradable polymer as a drug delivery system, it is possible to control the rate of release and concentration of the drug.…”

Section: Introductionmentioning

confidence: 99%

Formation of biodegradated polymers as components of future composite materials on the basis of shape memory alloy of medical appointment

Nasakina

Баикин

Sergiyenko

et al. 2018

IOP Conf. Ser.: Mater. Sci. Eng.

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Abstract. The processes of formation of polymer polylactide or polyglycylidactide films for the subsequent creation of a layered composite with a biodegradable layer on the basis of a nickel-free shape memory alloy TiNbTaZr are studied. The structure of the samples was determined using an SEM. The correspondence of morphology of surfaces of and the substrate itself is noted. High adhesion of the polymer to the future basis of the developed composite material is supposed. The formed films is homogeneous and amorphous throughout the polymer volume. By varying the volume of solutions, it is possible to obtain films of a given thickness for any type of polymer, its molecular weight, and the solution concentration of the polymer in chloroform. Poly (glycolide-lactide) should be more plastic than polylactide.

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Biocompatibility of new materials based on nano-structured nitinol with titanium and tantalum composite surface layers: experimental analysis in vitro and in vivo

Sevostyanov

Nasakina

Баикин

et al. 2018

J Mater Sci: Mater Med

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A technology for obtaining materials from nanostructured nitinol with titanium- or tantalum-enriched surface layers was developed. Surface layers enriched with titanium or tantalum were shown to provide a decrease in the formation of reactive oxygen species and long-lived protein radicals in comparison to untreated nitinol. It was determined that human peripheral vessel myofibroblasts and human bone marrow mesenchymal stromal cells grown on nitinol bases coated with titanium or tantalum-enriched surface layers exhibit a nearly two times higher mitotic index. Response to implantation of pure nitinol, as well as nano-structure nitinol with titanium or tantalum-enriched surface layers, was expressed though formation of a mature uniform fibrous capsule peripherally to the fragment. The thickness of this capsule in the group of animals subjected to implantation of pure nitinol was 1.5 and 3.0-fold greater than that of the capsule in the groups implanted with nitinol fragments with titanium- or tantalum-enriched layers. No signs of calcinosis in the tissues surrounding implants with coatings were observed. The nature and structure of the formed capsules testify bioinertia of the implanted samples. It was shown that the morphology and composition of the surface of metal samples does not alter following biological tests. The obtained results indicate that nano-structure nitinol with titanium or tantalum enriched surface layers is a biocompatible material potentially suitable for medical applications.

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Kinetics of the release of antibiotics from chitosan-based biodegradable biopolymer membranes

Cited by 20 publications

References 9 publications

The Kinetics of Lincomycin Release From Biopolymer Biodegradable of Membranes Based on High Density Chitosan

The Kinetics of Lincomycin Release From Biopolymer Biodegradable of Membranes Based on High Density Chitosan

Formation of biodegradated polymers as components of future composite materials on the basis of shape memory alloy of medical appointment

Biocompatibility of new materials based on nano-structured nitinol with titanium and tantalum composite surface layers: experimental analysis in vitro and in vivo

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