Kinetik und Wege des Methanolumsatzes

Rietbrock, N.

doi:10.1007/bf00549445

Cited by 32 publications

(3 citation statements)

References 34 publications

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“…As the German threshold limit value (MAK) is 200 ppm methanol, we exposed voluntary subjects to 200 ppm for 4 h in an exposure chamber. In contrast to intoxication with optic neuropathy, due to oral ingestion of large amounts of methanol which is metabolized to formate, being the main toxic agent, acute exposure to 200 ppm methanol does not increase serum concentrations of formaldehyde and of formate [24,31,36,40]. So possible eects could be related to the action of methanol itself.…”

Section: Introductionmentioning

confidence: 70%

“…As acute exposure to 200 ppm methanol does not increase serum concentrations of formaldehyde and of formate [24,31,36,40], the decrease of h-power in the human EEG has to be explained by eects of methanol itself. With respect to a kinetic study [36], after 3.5 h, concentrations in the magnitude of 5 mg methanol/l serum can be assumed in our test subjects.…”

Section: Discussionmentioning

confidence: 96%

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Acute effects on the human EEG after an external exposure to 200 ppm methanol

Muttray

Kurten

Jung

et al. 2000

International Archives of Occupational and Environmental Health

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Section: Introductionmentioning

confidence: 70%

Section: Discussionmentioning

confidence: 96%

Acute effects on the human EEG after an external exposure to 200 ppm methanol

Muttray

Kurten

Jung

et al. 2000

International Archives of Occupational and Environmental Health

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“…First investigations on human methanol metabolism with non toxic levels began already in the early seventies by Majchrowicz and Magrinat (Magrinat, 1973, Majchrowicz and Mendelson, 1970, Majchrowicz and Sutherland, 1971, Majchrowicz and Mendelson, 1971, Majchrowicz and Steinglass, 1973, Machrowicz, 1975 as well as Pieper and Skeen (1973) in chimpanzees (in general species differences esp. in studies on methanol metabolism in rats have to be considered, Rietbrock, 1969, Roe, 1982. Elevated methanol levels were detected in those studies and connections with withdrawal symptoms were discussed.…”

Section: Introductionmentioning

confidence: 99%

Methanol and congeners as markers of alcohol use and abuse

Gilg

2001

New and Upcoming Markers of Alcohol Consumption

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Congener analysis and especially methanol contribute to evaluate and differentiate a declared consumption of various alcoholic beverages, e.g. to judge post offence drinking claims. Methanol with serum (or urinary) levels exceeding 10 mg II cannot be achieved by short time drinking, except with fruit brandy (which can be identified by concomitantly elevated levels of butanol -2 and MEK (methyl ethyl ketone, as its metabolic product). Numerous results and experiences indicate that methanol, as well as acetone> 7 mg I 1 and isopropanol> 2 mg I 1 resp. acetone + isopropanol> 9 mg I 1, are markers for recent heavy drinking resp. long periods of alcoholization. At least they indicate alcohol abuse in blood or urine samples taken in alcoholized states or in earlier phases (hours) after drinking. The biological turnover (half time Apr. 2, 4 hours in methanol) has to be considered, which -as generally in marker studies -may affect the outcome of studies with respect to sensitivity. Its main use is more the detection of heavy prolonged drinking as in traffic and social medicine and in intensive care units to recognize possible withdrawals than as a relapse marker. It fits in the time screen of other markers as a short time marker. Methanol metabolism presents interesting aspects in view of the development of addiction and dependency (influence on the Cl metabolism) as well as on hangover and withdrawal.Methanol and congeners as markers of alcohol use and abuse 37

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Methylformiat [BAT Value Documentation in German language, 2003]

Drexler¹,

Csanády²

2012

The MAK‐Collection for Occupational Health and Safety

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Veröffentlicht in der Reihe Biologische Arbeitsstoff‐Toleranz‐Werte (BAT‐Werte) und Expositionsäquivalente für krebserzeugende Arbeitsstoffe (EKA) , 11. Lieferung, Ausgabe 2003 Der Artikel enthält folgende Kapitel: Metabolismus und Kinetik Kritische Toxizität Belastung und Beanspruchung Beanspruchung Belastung und Beanspruchung Hintergrundbelastung mit Methanol Bewertung der Indikatoren und Evaluierung des BAT‐Wertes

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Kinetik und Wege des Methanolumsatzes

Cited by 32 publications

References 34 publications

Acute effects on the human EEG after an external exposure to 200 ppm methanol

Acute effects on the human EEG after an external exposure to 200 ppm methanol

Methanol and congeners as markers of alcohol use and abuse

Methylformiat [BAT Value Documentation in German language, 2003]

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