Kinin‐forming activity and histamine in lymph after tissue injury

Edery, H.; Lewis, G P

doi:10.1113/jphysiol.1963.sp007280

Cited by 124 publications

(49 citation statements)

References 13 publications

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“…In rats the kinin-forming enzyme in plasma seems to be more easily activated, and its substrate is apparently more unstable than that from the plasma of several other animals (unpublished results). Edery & Lewis (1963) were able to prevent the increased kinin formation on incubation of pseudoglobulin with lymph from a scalded limb by intra-arterial injection of an antihistaminic drug before scalding. In similar experiments we observed that the amounts in lymph of substrates for kinin-forming enzymes increase after scalding.…”

Section: Discussionmentioning

confidence: 99%

“…Scalding of hind limbs of dogs and rabbits leads to the well-known increase in lymph flow (Starling, 1894;Field, Drinker & White, 1932;Edery & Lewis, 1963) and in lymph content of total protein, with a decrease in the lymph albumin-globulin ratio (Perlmann, Glenn & Kaufman, 1943). The concentration of protein in lymph approaches that in plasma.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The Effect of Scalding on the Content of Kininogen and Kininase in Limb Lymph

Jacobsen

Waaler

1966

British Journal of Pharmacology and Chemotherapy

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The Effect of Scalding on the Content of Kininogen and Kininase in Limb Lymph

Jacobsen

Waaler

1966

British Journal of Pharmacology and Chemotherapy

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“…This fact strengthens the view that histamine and 5-hydroxytryptamine play a role in the early phases of some types of acute inflammatory responses. The activation of the kinin system, either through the intervention of released histamine as suggested by Edery & Lewis (1963) or directly by the action of kininogens present in plasma and in the subcutaneous tissues would maintain the early vascular response (increased permeability to large molecules) to the point where the amount of extravasated proteins would be sufficient to induce the leakage of water through the vessel walls. In this respect, hexadimethrine bromide besides acting as an anti-inflammatory agent (Kellet, 1965;Garcia Leme et al, 1967) and having a marked inhibitory effect upon the activation of the kinin system (Armstrong & Stewart, 1962;Garcia Leme et al, 1970) proved in the present experiments to be a potent agent in counteracting the development of oedema and dye-leakage.…”

Section: Discussionmentioning

confidence: 99%

Pharmacological analysis of the acute inflammatory process induced in the rat's paw by local injection of carrageenin and by heating

Leme¹,

Hamamura²,

Leite³

et al. 1973

British J Pharmacology

122

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Summary1. Local injection of carrageenin in the rat's paw produced oedema and leakage of dye which had been administered previously by the intravenous route. A net dissociation between both parameters was observed: while oedema developed slowly, maximal intensity being attained after 4-5 h, dye-leakage was maximum after 1 hour. 2. Anti-inflammatory drugs such as acetylsalicylic acid and indomethacin were effective in reducing oedema and dye-leakage when given before the injection of carrageenin, but much less effective when given 30 or 60 min after carrageenin. Hexadimethrine bromide was effective in reducing dye-leakage also when given 1 h after the injection of carrageenin. 3. Combined administration of benadryl and methysergide, before the injection of carrageenin caused only a slight reduction in oedema and dye-leakage.4. When the paws were heated (550 C for 30 s) as a noxious stimulus the dissociation between maximal oedema and maximal dye-leakage was not observed, both phenomena running parallel. Pre-treatment of the animals with indomethacin did not afford any protection. 5. These results suggest that the inflammatory reaction to mild stimuli (carrageenin in our experiments) develops through different phases: initially the increased vascular permeability involves extravasation of plasma proteins and that phase is followed by an increased permeability mainly to water. Stronger stimuli (heating in our experiments) produce an overlapping of both phases, probably by inflicting severe damage to the vascular bed of the affected area.6. The anti-inflammatory drugs employed affected chiefly the initial phase of the response. 1fitroductionDyes injected intravenously localize in areas of developing inflammatory reactions. Using xylene as an irritant applied to the skin of rabbits, Rigdon (1939Rigdon ( , 1940 was able to show that Trypan blue and Indian ink concentrate in the injured areas only when injected into the circulation immediately after or within a period of less than 3-5 h following the application of xylene, though after that time these skin areas exhibited all the macroscopic and microscopic alterations associated with the inflammatory response. Rigdon concluded that increased vascular permeability is of brief duration following injury where xylene is applied.

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“…Kinin formation may therefore occur secondary to the release of these two biogenic amines, as histamine (Edery & Lewis, 1963) and 5-HT (Bonta & de Vos, 1965) have been reported to promote the release of kinin-forming enzyme and the formation of kinin respectively. Thus the passage of kinin precursors into the inflamed regions may be augmented by the influence of these "'primary " mediators, and kinin activation might then occur through the dilution of these precursors in oedema fluid or by their contact with foreign tissue surfaces.…”

Section: Discussionmentioning

confidence: 99%