Rotation minimizing (RM) vector fields and frames were introduced by Bishop as an alternative to the Frenet frame. They are used in CAGD because they can be defined even when the curvature vanishes. Nevertheless, many other geometric properties have not been studied. In the present paper, RM vector fields along a curve immersed into a Riemannian manifold are studied when the ambient manifold is the Euclidean 3-space, the hyperbolic 3-space, and a Kähler manifold.