Kisspeptin-1 directly stimulates LH and GH secretion from goldfish pituitary cells in a Ca2+-dependent manner

Chang, John P.; Már, A.; Wlasichuk, M.; Wong, Anderson O. L.

doi:10.1016/j.ygcen.2012.07.028

Cited by 52 publications

(23 citation statements)

References 49 publications

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“…This lack of differential GnRH1 and GnRH3 expression in face of downregulation of gonadotrophin b-subunit gene expression is surprising since it has been shown that neurons projecting from olfactory regions express GnRH1 and GnRH3 gene products (González-Martínez et al, 2001;Kah et al, 2007) and ablation of GnRH3 in zebrafish lead to reduced fecundity (Abraham et al, 2010). Our gene expression results for KISS2 and gonadotrophin b-subunits suggest a direct action of kisspeptin in the pituitary in this species, as had been suggested for rats, goldfish (C. auratus) and striped bass (Morone saxatilis) (Chang et al, 2012;Gutiérrez-Pascual et al, 2007;Zmora et al, 2014). In sea bass kiss2 neurons have been mapped mainly to the hypothalamus with projections to the subpallium and pallium, the preoptic region, the thalamus, the pretectal area, the optic tectum, the torus semicircularis, the mediobasal medial and caudal hypothalamus, and the neurohypophysis (Escobar et al, 2013a,b).…”

Section: Discussionsupporting

confidence: 54%

Lack of evidence for a role of olfaction on first maturation in farmed sea bass Dicentrarchus labrax

Saraiva

Martins

Hubbard

et al. 2015

General and Comparative Endocrinology

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Section: Discussionsupporting

confidence: 54%

Lack of evidence for a role of olfaction on first maturation in farmed sea bass Dicentrarchus labrax

Saraiva

Martins

Hubbard

et al. 2015

General and Comparative Endocrinology

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“…However, the finding that NLT kiss2 and Kiss1 coincide with NH projections in prespawning females and males suggests that these neurons also innervate the pituitary. The dual presence of the 2 kisspeptins in the NH may enable the kisspeptins not only to interact with gnrh projections but also bind gonadotropes and somatotropes (16,18) and, in turn, perhaps enhance the gnrh effect. Moreover, it is likely that at least in preovulatory females, the effect of kiss1 and kiss2 neurons is positive, because, as alluded to earlier, kisspeptin is essential for this process and the Lh surge that precedes it.…”

Section: Kiss1 and Kiss2 Neurons Temporal Appearance In The Nlt At Thmentioning

confidence: 99%

“…There are indications that kisspeptin can also directly act at the pituitary level to stimulate Lh release (15)(16)(17)(18)(19)(20). However, despite the fact that kisspeptin is found in the median eminence-hypophysial portal blood (21), and that kisspeptin and its receptor are expressed in the pituitary (19,22,23), this pathway is considered negligible in mammals (21,24).…”

mentioning

confidence: 99%

“…However, despite the fact that kisspeptin is found in the median eminence-hypophysial portal blood (21), and that kisspeptin and its receptor are expressed in the pituitary (19,22,23), this pathway is considered negligible in mammals (21,24). The presence of kisspeptin receptor in fish pituitary is also reported (10) as well as in vitro stimulatory effect on Lh and Gh secretion in the goldfish (18) or an inhibitory effect on Lh, as in the case of the European eel (23).…”

mentioning

confidence: 99%

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The Medio-Basal Hypothalamus as a Dynamic and Plastic Reproduction-Related Kisspeptin-gnrh-Pituitary Center in Fish

et al. 2014

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Kisspeptin regulates reproductive events, including puberty and ovulation, primarily via GnRH neurons. Prolonged treatment of prepubertal striped bass females with kisspeptin (Kiss) 1 or Kiss2 peptides failed to enhance puberty but suggested a gnrh-independent pituitary control pathway. Kiss2 inhibited, but Kiss1 stimulated, FShβ expression and gonadal development, although hypophysiotropic gnrh1 and gnrh receptor expression remained unchanged. In situ hybridization and immunohistochemistry on brains and pituitaries revealed a differential plasticity between the 2 kisspeptin neurons. The differences were most pronounced at the prespawning phase in 2 regions along the path of gnrh1 axons: the nucleus lateralis tuberis (NLT) and the neurohypophysis. Kiss1 neurons appeared in the NLT and innervated the neurohypophysis of prespawning males and females, reaching Lh gonadotropes in the proximal pars distalis. Males, at all reproductive stages, had Kiss2 innervations in the NLT and the neurohypophysis, forming large axonal bundles in the former and intermingling with gnrh1 axons. Unlike in males, only preovulatory females had massive NLT-neurohypophysis staining of kiss2. Kiss2 neurons showed a distinct appearance in the NLT pars ventralis-equivalent region only in spawning zebrafish, indicating that this phenomenon is widespread. These results underscore the NLT as important nuclei for kisspeptin action in 2 facets: 1) kisspeptin-gnrh interaction, both kisspeptins are involved in the regulation of gnrh release, in a stage- and sex-dependent manner, especially at the prespawning phase; and 2) gnrh-independent effect of Kiss peptides on the pituitary, which together with the plastic nature of their neuronal projections to the pituitary implies that a direct gonadotropic regulation is plausible.

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“…In contrast, Kisspeptin (Kiss) is a neuropeptide that has recently been detected in the hypothalamus (Lee et al 1996) and regulates sexual differentiation and spawn time in fish through the activation of the HPG axis (Funes et al 2003;Seminara et al 2003). Additionally, Kiss acts as a sex maturation-regulating factor by activating certain nerves in the brain through the regulation of GnRH expression (Chang et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Effects of various photoperiods on Kisspeptin and reproductive hormones in the goldfish,Carassius auratus

Shin

Song

Choi

et al. 2014

Animal Cells and Systems

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The study aimed to test differences in the hormones of the hypothalamus-pituitary-gonad axis, Kisspeptin (Kiss) and sex steroids, and the sexual maturation of goldfish (Carassius auratus) according to various photoperiods: 10 h light (L):14 h dark (D) (short day), 12L:12D (control), and 14L:10D (long day). To investigate the sexual maturation under various photoperiods, quantitative real-time PCR (QPCR) assays for salmon gonadotropin-releasing hormone, chicken gonadotropinreleasing hormone, gonadotropin hormones (GTHs), Kisspeptin 1 (Kiss1), and its receptor, G protein-coupled receptor 54 (GPR54), were developed. mRNA expression was monitored in cultured pituitary cells (in vitro) of various photoperiod groups. Furthermore, we injected or treated the animals with Kiss and found that Kiss treatment increases the mRNA expression levels of GTHs. We measured the plasma follicle-stimulating hormone (FSH), luteinizing hormone (LH), and 17α-hydroxypregnenolone levels. The gonadotropin-releasing hormones (GnRHs), GTHs, Kiss1/GPR54 mRNA expression, plasma FSH, LH, and 17α-hydroxypregnenolone levels in the 14L:10D group were significantly higher than in the other groups. These results suggest that light length regulates sex maturation by GnRH and Kiss1 in the brain of the goldfish.

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Kisspeptin-1 directly stimulates LH and GH secretion from goldfish pituitary cells in a Ca2+-dependent manner

Cited by 52 publications

References 49 publications

Lack of evidence for a role of olfaction on first maturation in farmed sea bass Dicentrarchus labrax

Lack of evidence for a role of olfaction on first maturation in farmed sea bass Dicentrarchus labrax

The Medio-Basal Hypothalamus as a Dynamic and Plastic Reproduction-Related Kisspeptin-gnrh-Pituitary Center in Fish

Effects of various photoperiods on Kisspeptin and reproductive hormones in the goldfish,Carassius auratus

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