Kisspeptin-13 enhances memory and mitigates memory impairment induced by Aβ1–42 in mice novel object and object location recognition tasks

Jiang, Jielin; He, Zhijie; Peng, Yan; Jin, Weidong; Wang, Z.; Han, Ren-wen; Chang, Min; Wang, R.

doi:10.1016/j.nlm.2015.05.010

Cited by 41 publications

(31 citation statements)

References 45 publications

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“…Loss of kisspeptin signalling also appears to reduce anxiety-related behaviours in mice (Delmas et al 2018). Another emerging effect of kisspeptin is the enhancement of memory capabilities in mice (Jiang et al 2015). Despite these findings, the nature in which kisspeptin may bring about these limbic effects is not fully understood.…”

Section: Discussionmentioning

confidence: 99%

The role of kisspeptin neurons in reproduction and metabolism

Harter

Kavanagh

Smith

2018

Journal of Endocrinology

126

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Kisspeptin is a neuropeptide with a critical role in the function of the hypothalamic-pituitary-gonadal (HPG) axis. Kisspeptin is produced by two major populations of neurons located in the hypothalamus, the rostral periventricular region of the third ventricle (RP3V) and arcuate nucleus (ARC). These neurons project to and activate gonadotrophin-releasing hormone (GnRH) neurons (acting via the kisspeptin receptor, Kiss1r) in the hypothalamus and stimulate the secretion of GnRH. Gonadal sex steroids stimulate kisspeptin neurons in the RP3V, but inhibit kisspeptin neurons in the ARC, which is the underlying mechanism for positive- and negative feedback respectively, and it is now commonly accepted that the ARC kisspeptin neurons act as the GnRH pulse generator. Due to kisspeptin's profound effect on the HPG axis, a focus of recent research has been on afferent inputs to kisspeptin neurons and one specific area of interest has been energy balance, which is thought to facilitate effects such as suppressing fertility in those with under- or severe over-nutrition. Alternatively, evidence is building for a direct role for kisspeptin in regulating energy balance and metabolism. Kiss1r-knockout (KO) mice exhibit increased adiposity and reduced energy expenditure. Although the mechanisms underlying these observations are currently unknown, Kiss1r is expressed in adipose tissue and potentially brown adipose tissue (BAT) and Kiss1rKO mice exhibit reduced energy expenditure. Recent studies are now looking at the effects of kisspeptin signalling on behaviour, with clinical evidence emerging of kisspeptin affecting sexual behaviour, further investigation of potential neuronal pathways are warranted.

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Section: Discussionmentioning

confidence: 99%

The role of kisspeptin neurons in reproduction and metabolism

Harter

Kavanagh

Smith

2018

Journal of Endocrinology

126

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“…Intracerebroventricular (i.c.v.) administration was performed as described previously . Briefly, mice (20 ± 1 g) were anesthetized with pentobarbital sodium (i.p.…”

Section: Methodsmentioning

confidence: 99%

“…administration was performed as described previously. [15] Briefly, mice (20 AE 1 g) were anesthetized with pentobarbital sodium (i.p. 70 mg/kg) and placed on the stereotaxic apparatus.…”

Section: Drug Administrationmentioning

confidence: 99%

Supraspinal inhibitory effects of chimeric peptide MCRT on gastrointestinal motility in mice

Zhang

et al. 2017

Journal of Pharmacy and Pharmacology

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(1) Morphiceptin and PFRTic-NH played important roles in the regulation of gastrointestinal motility; (2) MCRT possessed higher bioactivity of pain relief than gastrointestinal regulation, suggesting its promising analgesic property; (3) MCRT-induced motility disorders were sensitive to DOR but not to MOR blockade, indicating the pain-relieving specificity of speculated MOR subtype or splice variant or MOR-DOR heterodimer.

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“…The surgery of cannula implanted was conducted as described in our previous reports [16,28,29]. Mice (18-22 g) were anesthetized with pentobarbital sodium (Sigma-Aldrich Co., United States, 70 mg/kg; i.p.…”

Section: Stereotaxic Surgery and Treatmentmentioning

confidence: 99%