Kisspeptin-52 partially rescues the activity of the hypothalamus-pituitary-gonadal axis in underweight male rats dosed with an anti-obesity compound

Bolze, Florian; Williams, Hannah L.; Bhuwania, R.; Egecioglu, Emil; Bloem, Esther; Paulsson, Johan; Pedersen, Marie Østergaard; Broadmeadow, A.; Chesher, Clare J.; Moore, Emma L.; Skydsgaard, Mikala; Galle, Pia; Dalgaard, Majken; Wulff, Birgitte S.; Tena‐Sempere, Manuel; Andersen, Lennart

doi:10.1016/j.taap.2020.115152

Cited by 1 publication

(1 citation statement)

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“…Furthermore, previous studies have shown the therapeutic potential of kisspeptin in males with testicular dysfunction. Accordingly, the kisspeptin receptor (kiss1r) agonists have been found to restore testosterone levels in Rhesus monkeys with the HPG axis blockade caused by cortisol 21 and underweight male rats dosed with an anti-obesogenic compound 22 .…”

Section: Introductionmentioning

confidence: 99%

Kisspeptin treatment reverses high prolactin levels and improves gonadal function in hypothyroid male rats

Santos,

dos Anjos Cordeiro,

da Silva Santana

et al. 2023

Sci Rep

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We evaluated whether the administration of kisspeptin-10 (Kp10) is capable of restoring gonadal function in hypothyroid male rats. Hypothyroidism was induced with 6-propyl-2-thiouracil (PTU) for three months. In the last month, half of the hypothyroid animals were treated with Kp10. Hypothyroidism reduced testicular and sex gland mass, decreased the proliferation of the seminiferous epithelium, and compromised sperm morphology, motility, and vigor. A decrease in plasma LH and testosterone levels and an increase in prolactin secretion were observed in the hypothyroid rats. Hypothyroidism reduced Kiss1 and Kiss1r protein and gene expression and Star and Cyp11a1 mRNA levels in the testis. Furthermore, it reduced Lhb, Prl, and Drd2 and increased Tshb and Gnrhr expression in the pituitary. In the hypothalamus, hypothyroidism increased Pdyn and Kiss1r while reducing Gnrh1. Kp10 treatment in hypothyroid rats restored testicular and seminal vesicle morphology, improved sperm morphology and motility, reversed high prolactin levels, and increased LH and testosterone levels. In addition, Kp10 increased testicular expression of Kiss1, Kiss1r, Fshr, and Nr5a1 and pituitary Kiss1 expression. Our findings describe the inhibitory effects of hypothyroidism on the male gonadal axis and sperm quality and demonstrate that Kp10 treatment reverses high prolactin levels and improves gonadal function and sperm quality in hypothyroid rats.

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Section: Introductionmentioning

confidence: 99%