Kisspeptin and attributes of infertile males and females: A cross‐sectional study in a subset of Pakistani population

Rehman, Rehana; Fatima, Syeda Sadia; Alam, Faiza; Ashraf, Muhammad Waqar; Zafar, Shaheen

doi:10.1111/and.13370

Cited by 11 publications

(10 citation statements)

References 25 publications

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“…These forms all share a common C-terminal decapeptide (KP10), which is required for binding with its receptor KISS1R (also known as GPR54) [12]. Given its vital functions, KISS1 gene SNPs were studied in precocious puberty, polycystic ovarian syndrome, and male infertility in different clinical and geographical settings [13][14][15]. To the best of our knowledge, no study was conducted, at least in Iraq, to examine the role of KISS1 gene SNPs in idiopathic male infertility.…”

Section: Introductionmentioning

confidence: 99%

Role of Kisspeptin Gene Polymorphism in Idiopathic Male Infertility in Iraq

Al-Kalabi¹,

AL-Azzawie

Al-Wasiti

2021

eijs

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This case control study aimed to determine single nucleotide polymorphisms (SNPs) in the Kisspeptin (KISS1) gene in males with idiopathic infertility and their association with sex hormones and semen quality. The study included a total of 60 infertile and 30 healthy fertile males. Our results show that the level of the measured hormones (LH, FSH, Testosterone, Prolactin and Kisspeptin-54) were higher in the control group than in the male infertile group at p<0.05. We used polymerase chain reaction restriction fragment length polymorphism (PCR-RELP) for the genotyping of KISS1 position rs35431622 (Q36R) KISS1, which showed three different genotypes of different sizes; a wild-type homozygous AA of 233 bp and a heterozygous AG that has digestion products of 233, 161, and 72 bp. The AG was more frequent in the patients group which also had high OR value of G allele (3.105). While for the rs4889 (C/G(, there was a correlation between the CC genotype and the patients group, but it was non-significant. Patients had an OR value of 2.5 for the CC genotype with 95% CI: 0.21 – 29.26, whereas the OR value for the C allele was 1.14 with 95% CI: 0.613 – 2.135. In conclusion, variations in SNPs of the KISS1 gene may be considered as a risk factor for idiopathic male infertility in Iraqi population.

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Section: Introductionmentioning

confidence: 99%

Role of Kisspeptin Gene Polymorphism in Idiopathic Male Infertility in Iraq

Al-Kalabi¹,

AL-Azzawie

Al-Wasiti

2021

eijs

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“…Activating and inactivating mutations in KISS1 or KISS1R genes cause pubertal failure and precocious puberty in children [15][16][17]. Concentrations of hypothalamic KP were causally associated with GnRH activation and reproductive maturation in humans [9,[18][19][20][21]. Prevalence of CPP has been predicted to be 0.2% in general population [22], and interestingly, females are at least 10 times more likely to develop premature puberty than males [6,23].…”

Section: Introductionmentioning

confidence: 99%

Kisspeptin Levels in Girls with Precocious Puberty: A Systematic Review and Meta-Analysis

et al. 2020

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Background/Aims: Kisspeptin (KP) is a key player in the regulation of the release of gonadotropin-releasing hormone (GnRH), which increases the secretion of gonadotropin during puberty to establish reproductive function and regulate the hypothalamic-pituitary-gonadal axis. Premature activation of GnRH secretion leads to idiopathic/central gonadotropin-dependent precocious puberty (CPP). We aimed to compare the blood KP concentrations in girls with CPP and healthy controls. Methods: A systematic review and meta-analysis was performed. We searched MEDLINE, EMBASE, The Cochrane Library, and SciELO. Random-effects model and standardized mean difference (SMD) were used. Heterogeneity was assessed through I2. Meta-regression considered patient age, KP fraction, and analytical method for KP measurement. Results: The 11 studies included comprised 316 CPP patients and 251 controls. Higher KP levels in the CPP group were found (SMD 1.53; CI 95% = 0.56–2.51). Subgroup analysis revealed association with patient age (p = 0.048), indicating a positive correlation between elevation in KP concentration and age in CPP group. A group of patients with precocious thelarche (PT) from 5 of the included studies comprising 121 patients showed higher levels of KP (1.10; −0.25–2.45: CI 95%) and high heterogeneity (I2 = 91%). The CPP/PT ratio for KP level indicates KP 36% higher on CPP than PT patients. Conclusions: A consistent difference in KP levels between girls with CPP and controls was identified. While there are important limitations in KP assays which argue against its use as a diagnostic tool, the KP levels in CPP versus control and PT children are consistent with the predicted mechanisms and pathophysiology of CPP.

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“…Furthermore, we found a decrease in the level of KISS in males with CF compared with healthy males. In men, circulating KISS levels change in relation to fertility status, being significantly higher in fertile men than in infertile men 35 . The primary role of hypothalamic KISS is the regulation of gonadotropin releasing hormone secretion from neurons.…”

Section: Discussionmentioning

confidence: 99%

Serum kisspeptin and proopiomelanocortin in cystic fibrosis: a single study

Galiniak

Podgórski

Rachel

et al. 2022

Sci Rep

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The determination of hormonal biomarkers is of increasing interest in many diseases, including cystic fibrosis (CF). Hormones that have not been estimated and described so far in CF include kisspeptin (KISS) and proopiomelanocortin (POMC), which are involved in the regulation of many processes, including appetite and fertility. Therefore, the aim of our study was to estimate the level of KISS and POMC in sera from CF patients and to determine the correlation between these hormones and clinical parameters. For this purpose, we estimated the levels of KISS and POMC in 38 CF patients and 16 healthy participants with enzyme-linked immunosorbent assay. We found significantly reduced levels of KISS and POMC in people with CF compared to healthy subjects (1.76 ± 0.46 vs. 2.27 ± 0.56 ng/mL, p < 0.05 and 6.25 ± 4.36 vs. 14.74 ± 6.24 ng/mL, p < 0.001, respectively). Furthermore, the level of both hormones was negatively correlated with age. The hormones studied did not correlate with the results of spirometry and each other. Thus, decreased KISS and POMC levels may be associated with lower body weight and delayed puberty in patients with CF.

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Kisspeptin and attributes of infertile males and females: A cross‐sectional study in a subset of Pakistani population

Cited by 11 publications

References 25 publications

Role of Kisspeptin Gene Polymorphism in Idiopathic Male Infertility in Iraq

Role of Kisspeptin Gene Polymorphism in Idiopathic Male Infertility in Iraq

Kisspeptin Levels in Girls with Precocious Puberty: A Systematic Review and Meta-Analysis

Serum kisspeptin and proopiomelanocortin in cystic fibrosis: a single study

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