Kisspeptin, Leptin, and Retinol-Binding Protein 4 in Women with Polycystic Ovary Syndrome

Abstract

Objectives: To compare plasma kisspeptin, serum leptin, and serum retinol-binding protein 4 (RBP4) levels in women with and without polycystic ovary syndrome (PCOS) and to correlate these among each other and with clinical, hormonal, and metabolic parameters. Methods: Ninety women, including 54 women with PCOS and 36 without PCOS, participated in this study. For all patients, history and physical examinations were performed and blood samples were collected between days 3 and 8 of a spontaneous bleeding episode in the PCOS group and during normal menses of controls. Plasma kisspeptin, serum leptin, and serum RBP4 levels were measured using specific commercial assays. Results: Kisspeptin, leptin, and RBP4 levels were significantly higher in the PCOS group than in controls. Kisspeptin and RBP4 levels were significantly higher among obese PCOS patients than controls. Leptin levels were higher among obese PCOS patients than non-obese PCOS patients or controls. Kisspeptin and leptin levels of PCOS patients were significantly correlated with RBP4 levels. When only obese PCOS patients were analyzed, kisspeptin levels correlated with only the free androgen index. Conclusions: These findings suggest that kisspeptin, leptin, and RBP4 are associated with metabolic disturbances in women with PCOS.

Kisspeptin and polycystic ovary syndrome - is there any connection?

“…Результаты обследования больных СПЯ показали, что уровень кисспептина в пери-ферической крови на 2-й день менструаль-ного цикла имеет тенденцию к повышению (0,64 ± 0,06 нг/мл) по сравнению с показателя-ми в контрольной группе (0,57 ± 0,04 нг/мл), что не противоречит данным других авто ров [6][7][8], однако отличия не были достоверными. Полученные нами результаты также согласу-ются с ретроспективным исследованием, про-веденным в 2016 г. и включившим 285 пациен-ток с СПЯ и 162 женщины, составившие группу контроля [9].…”

“…Была определена прямая корреляция между уровнем кисспептина в периферической крови у пациенток с СПЯ, страдающих ожире-нием, и индексом свободных андрогенов [7]. В исследовании S. Yilmaz et al (2014) было изучено содержание в сыворотке крови уровня кисспептина у здоровых женщин и у больных СПЯ, как с избытком массы тела или ожире-нием, так и с нормальным весом [8].…”

Role of Kisspeptine in Regulation of Reproductive Function

“…Была определена прямая корреляция уровня кисспептина у пациенток с СПя, страдающих ожирением, с индексом свободных андроге-нов [122].…”

Association between retinol-binding protein 4 and polycystic ovary syndrome: A meta-analysis

“…Another one was excluded because it was a duplicate publication. At last, a total of seven studies (376 cases and 260 controls) were included in our meta-analysis [7,[13][14][15][16][17][18]. A flow chart describing the process of study inclusion/exclusion is displayed as Fig.…”

“…A meta-analysis of the seven studies, which included a total of 636 subjects (260 controls and 376 patients with PCOS), was performed [7,[13][14][15][16][17][18]. Data were all extracted as means±SD, the P value of heterogeneity between studies was with significance (P <0.05, Fig.…”