Kitamycin C, a new antimycin-type antibiotic from <i>Streptomyces antibioticus</i> strain 200-09

Fan, Wei; Fu, Shuna; Bao, Yixuan; Yu, Yang; Shen, Huifeng; Lin, Bei; Zhou, Guang‐Xiong

doi:10.1080/14786419.2017.1295240

Cited by 9 publications

(3 citation statements)

References 13 publications

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“…S. antibioticus was originally isolated from soil and is well known for its potential to produce several bioactive compounds, including several antibiotics. There are strains of S. antibioticus isolated form marine environment which may explain the halophilic properties of the Streptomyces S3 isolate (Sharma et al, 2019;Waksman and Woodruff, 1941;Wang et al, 2017;Xu et al, 2011). Automated genome blast-based phylogeny retrieved from NCBI indicated that soil environmental isolate Streptomyces sp.…”

Section: Genome Analysismentioning

confidence: 99%

The Microbiome of a Shell Mound: Ancient Anthropogenic Waste as a Source of Streptomyces Degrading Recalcitrant Polysaccharides

Huergo

Conzentino

Gonçalves

et al. 2021

Preprint

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Metagenome amplicon DNA sequencing and traditional cell culture techniques are helping to uncover the diversity and the biotechnological potential of prokaryotes in different habitats around the world. It has also had a profound impact on microbial taxonomy in the last decades. Here we used metagenome 16S rDNA amplicon sequencing to reveal the microbiome composition of different layers of an anthropogenic soil collected at a shell mound Sambaqui archeological site. The Samabaqui soil microbiome is mainly composed by phyla Acidobacteria, Rokubacteria, Proteobacteria and Thaumarchaeota. Using culture-dependent analysis we isolated few Streptomyces strains from the Sambaqui soil. One of the isolates, named Streptomyces sp. S3, was able to grow in minimal medium containing recalcitrant polysaccharides including chitin, xylan, carboxymethylcellulose or microcrystalline cellulose as sole carbon sources. The activities of enzymes degrading these compounds were confirmed in cell free supernatants. The genome sequence revealed not only an arsenal of genes related to polysaccharides degradation but also biosynthetic gene clusters which may be involved in the production of biotechnologically interesting secondary metabolites.

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Section: Genome Analysismentioning

confidence: 99%

The Microbiome of a Shell Mound: Ancient Anthropogenic Waste as a Source of Streptomyces Degrading Recalcitrant Polysaccharides

Huergo

Conzentino

Gonçalves

et al. 2021

Preprint

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“…They are characterized by a nine-membered dilactone skeleton substituted with one alkyl (C7), one acyloxy (C8), two methyl moieties (C4 and C9), and a 3-formamidosalicylic acid linked to C3 by an amide connection . Although the most abundant members of this family are the ones with a nine-membered core, antimycin-type macrocyclic compounds with 12-, 15-, and 18-membered rings have also been reported. − Antimycins exhibit a broad spectrum of biological properties, including antifungal, − antiviral, , or mitochondrial electron transport inhibitors. − The first antimycin reported possessing a pyridyl group was the antibiotic UK-2A, isolated from an acetone extract of Streptomyces sp. 517-02 in 1996. , Biological and structure–activity relationships of UK-2A have been studied comparing its activity with those of other antimycins scaffolds like spleniocins. , The antifungal activity of these compounds has been described to be triggered by the inhibition of electron transport at mitochondrial complex III .…”

Section: Introductionmentioning

confidence: 99%

Escuzarmycins A–D, Potent Biofungicides to Control Septoria tritici Blotch

Fernández-Pastor,

González-Menéndez,

González

et al. 2024

J. Agric. Food Chem.

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A study targeting novel antifungal metabolites identified potent in vitro antifungal activity against key plant pathogens in acetone extracts of Streptomyces sp. strain CA-296093. Feature-based molecular networking revealed the presence in this extract of antimycin-related compounds, leading to the isolation of four new compounds: escuzarmycins A−D (1−4). Extensive structural elucidation, employing 1D and 2D NMR, high-resolution mass spectrometry, Marfey's analysis, and NOESY correlations, confirmed their structures. The bioactivity of these compounds was tested against six fungal phytopathogens, and compounds 3 and 4 demonstrated strong efficacy, particularly against Zymoseptoria tritici, with compound 3 exhibiting the highest potency (EC 50 : 11 nM). Both compounds also displayed significant antifungal activity against Botrytis cinerea and Colletotrichum acutatum, with compound 4 proving to be the most potent. Despite moderate cytotoxicity against the human cancer cell line HepG2, compounds 3 and 4 emerge as promising fungicides for combating Septoria tritici blotch, anthracnose, and gray mold.

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“…A new antimycintype antibiotic, kitamycin C was recently isolated from a culture broth of Streptomyces antibioticus strain 200-09. The compound exhibited strong antifungal activities against Candida albicans [25]. Two new antimycin A analogues were isolated from a spent broth of a marine-derived Streptomyces lusitanus, and these compounds also showed strong biological activity against Staphylococcus aureus and Loktanella hongkongensis [26].…”

Section: Introductionmentioning

confidence: 99%

Isolation and Evaluation of Streptomyces melanogenes YBS22 with Potential Application for Biocontrol of Rice Blast Disease

Song,

Wang,

Liu

et al. 2023

Microorganisms

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Plant diseases caused by pathogenic fungi pose a significant threat to agricultural production. This study reports on a strain YBS22 with broad-spectrum antifungal activity that was isolated and identified, and its active metabolites were purified and systematically studied. Based on a whole genome sequence analysis, the new strain YBS22 was identified as Streptomyces melanogenes. Furthermore, eight gene clusters were predicted in YBS22 that are responsible for the synthesis of bioactive secondary metabolites. These clusters have homologous sequences in the MIBiG database with a similarity of 100%. The antifungal effects of YBS22 and its crude extract were evaluated in vivo and vitro. Our findings revealed that treatment with the strain YBS22 and its crude extract significantly reduced the size of necrotic lesions caused by Magnaporthe oryzae on rice leaves. Further analysis led to the isolation and purification of an active compound from the crude extract of the strain YBS22, identified as N-formylantimycin acid methyl ester, an analog of antimycin, characterized by NMR and MS analyses. Consistently, the active compound can significantly inhibit the germination and development of M. oryzae spores in a manner that is both dose- and time-dependent. As a result, we propose that the strain YBS22 could serve as a novel source for the development of biological agents aimed at controlling rice blast disease.

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Kitamycin C, a new antimycin-type antibiotic from Streptomyces antibioticus strain 200-09

Cited by 9 publications

References 13 publications

The Microbiome of a Shell Mound: Ancient Anthropogenic Waste as a Source of Streptomyces Degrading Recalcitrant Polysaccharides

The Microbiome of a Shell Mound: Ancient Anthropogenic Waste as a Source of Streptomyces Degrading Recalcitrant Polysaccharides

Escuzarmycins A–D, Potent Biofungicides to Control Septoria tritici Blotch

Isolation and Evaluation of Streptomyces melanogenes YBS22 with Potential Application for Biocontrol of Rice Blast Disease

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