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Abstract

A series of 3-(5-substituted phenyl-1, 3, 4-Oxadiazol-2yl) pyridines was designed, synthesized and characterized for evaluation of potential antibacterial activity against Bacillus subtilis, Staphylococcus aureus, Escherichia coli, Klebsiella species and antifungal activity against Candida albicans. Structure-activity relationship led to the conculsion that compound IV b, and IV e exhibited good antibacterial activity against Bacillus subtilis and Staphylococcus aureus and comparatively poor activity against Klbesiella species and Escherichia coli. Compound C exhibited antibacterial activity against Staphylococcus aureus and very poor activity against rest of organism. Compounds IV a , IV b and IV e showed poor antifungal activity against Candida albicans and compounds IV c and IV d showed no significant antifungal activity. The interesting antimicrobial profile of compound IV b and IV e led us to select this derivative for further development. Present research our expected compounds were given below.