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Vardapetyan, Hrachik; Kirakosyan, Ara; Oganesyan, A. A.; Penesyan, Anahit; Alfermann, Willi.

doi:10.1023/a:1023853716376

Cited by 20 publications

(2 citation statements)

References 16 publications

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“…The effect of other elicitors, such as mannan, β‐1,3‐glucan and ancymidol, was studied in L. austriacum cell cultures in relation to the activity of key enzymes involved in lignan biosynthesis and are proposed to be involved with a higher synthesis of PTOX and peltatins [96].…”

Section: Elicitation Experimentsmentioning

confidence: 99%

Updated biotechnological approaches developed for 2,7′‐cyclolignan production¹

Lautie

Fliniaux

Villarreal

2010

Biotech and App Biochem

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2,7'-Cyclolignans constitute a group of compounds regularly employed in clinical contexts due to their antiviral and anticancer properties as expressed in a number of already available designed drugs. Possibilities for other therapeutic developments are indicated. All commercial preparations actually originate from a single compound, podophyllotoxin, currently extracted from a few limited-in-abundance species of Podophyllum. This supply problem has stimulated considerable interest in the development of alternative strategies offering greater sustainable availability of the compound at affordable costs. Approaches such as plant breeding and micropropagation of the high-producing Podophyllum species have been explored with the aim of establishing production of these compounds. Since 20 years of exploration of the total chemical synthesis of podophyllotoxin has not proved economically viable, extensive research has now been undertaken to find methods for stimulating the accumulation of 2,7'-cyclolignans using tissue cultures. Both undifferentiated and differentiated cell cultures, mainly from Linum, Podophyllum, Juniperus, Callitris, Anthriscus and Forsynthia genera, have been reported. Although considerable progress has been made concerning the concentration and productivity of certain strains of Linum album, no economically viable production system has been established. Exploration and development of biosynthetical pathways leading to 2,7'-cyclolignans may open paths for future metabolic engineering, such as the bioconversion of deoxypodophyllotoxin to epipodophyllotoxin employing a human hepatic enzyme heterologously expressed in Escherichia coli.

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Section: Elicitation Experimentsmentioning

confidence: 99%

Updated biotechnological approaches developed for 2,7′‐cyclolignan production¹

Lautie

Fliniaux

Villarreal

2010

Biotech and App Biochem

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“…The flowering and maturing stage of this plant lasts from May to July [1,2]. L. album contains important lignan compounds such as podophyllotoxin and 6-methoxypodophyllotoxin, which have antiviral and antitumoral properties [3]. Podophyllotoxin, a well-known lignan, serves as the unique starting compound for the semisynthesis of the leading anticancer drug Etoposide (VP16) and its derivatives (class of topoisomerase II inhibitors) used in a dozen anticancer chemotherapy treatments [4,5].…”

Section: Introductionmentioning

confidence: 99%

Morphological, Physiological, and Biochemical Impacts of Different Levels of Long-Term Water Deficit Stress on Linum album Ky. ex Boiss. Accessions

et al. 2020

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Linum album (Ky. ex Boiss.) is an important medicinal plant that produces compounds such as the well-known anticancer lignan podophyllotoxin and fatty acids. Despite its high medicinal value, it has not yet been studied in detail under agricultural conditions. This study was conducted to evaluate the morphological, phenological, and physiological responses of six L. album accessions under different levels of water deficit treatments (100%, 75%, 50%, and 25% available water) in pot conditions. Based on the results, some of the morphological characteristics of the response to water deficit were established. Accessions UTLA7, UTLA9, and UTLA10 showed a higher seed yield and dry weight of the vegetative part. There was a substantial difference in the occurrence of phenological stages in the accessions. The maturation process was accelerated in plants under stress conditions, and accession UTLA9 completed its complete growth cycle faster than the other accessions. The physiological responses of the different accessions did not show the same pattern on the basis of the characteristics studied, and significant differences were observed depending on the trait and accession. Among the most important results of this study was the diversity of responses in different accessions. Based on these results, it is recommended that morphological features (such as seed yield per plant, plant height, number of inflorescences per plant, shoot and root dry weight) be used to select tolerant accessions for the desired product.

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Feeding of Precursors

2020

Secondary Metabolites of Medicinal Plants

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Untitled

Cited by 20 publications

References 16 publications

Updated biotechnological approaches developed for 2,7′‐cyclolignan production¹

Updated biotechnological approaches developed for 2,7′‐cyclolignan production¹

Morphological, Physiological, and Biochemical Impacts of Different Levels of Long-Term Water Deficit Stress on Linum album Ky. ex Boiss. Accessions

Feeding of Precursors

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Untitled

Cited by 20 publications

References 16 publications

Updated biotechnological approaches developed for 2,7′‐cyclolignan production1

Updated biotechnological approaches developed for 2,7′‐cyclolignan production1

Morphological, Physiological, and Biochemical Impacts of Different Levels of Long-Term Water Deficit Stress on Linum album Ky. ex Boiss. Accessions

Feeding of Precursors

Contact Info

Product

Resources

About

Updated biotechnological approaches developed for 2,7′‐cyclolignan production¹

Updated biotechnological approaches developed for 2,7′‐cyclolignan production¹