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Singla, Rajeshree; Choe, Eun Sang; Lee, Chi H.

doi:10.1023/a:1020319329145

Cited by 3 publications

(1 citation statement)

References 20 publications

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“… The stem is bitter, stomachic, diuretic, stimulates corrosiveness concealment, allays thirst, enriches the blood and cures hostility (27).  The juice of plant stem is useful in diabetes, dyspepsia, vaginal and urethral discharges (28).  The dinghy of this plant acts as Anti-allergic, Anti-spasmodic, Anti-pyretic, Anti-leprotic (29)(30)(31).…”

Section: Medicinal Usesmentioning

confidence: 99%

Tinospora cordifolia as medicinal herb

Pooja Shivaji Jauk,

Shekhar Sahebrao Pandav,

Gajanan Suryabhan Sanap

2023

World J. Bio. Pharm. Health Sci.

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Tinospora cordifolia is a popular medicinal plant which is used in several traditional drugs to cure several conditions. The common names are Amrita and Guduchi and belong to family Menispermaceae.. It is considered an essential herbal plant of Indian system of drug(ISM) and has been used in the treatment of fever, urinary problem, dysentery, skin conditions leprosy, diabetes, and numerous further conditions. The plant reported containing chemical constituents including Alkaloids, Terpenoids, Lignans, Steroids and others that establish the photochemistry and pharmacological exertion of Tinospora cordifolia. The present review highlights the pharma ecological significance viz antioxidant exertion, antimicrobial exertion, antibacterial exertion, antifungal exertion, anti-diabetic exertion, antistress exertion, hypolipidaemic effect, hepatic complaint, anticancer anti HIV eventuality, antiosteoporotic goods, antitoxic goods, crack mending, anticomplementary exertion, and immunomodulation exertion, systemic infection and Parkinson’s complaint.

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Section: Medicinal Usesmentioning

confidence: 99%

Tinospora cordifolia as medicinal herb

Pooja Shivaji Jauk,

Shekhar Sahebrao Pandav,

Gajanan Suryabhan Sanap

2023

World J. Bio. Pharm. Health Sci.

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EDTA‐induced activation of Ca‐regulated proteins in the vaginal mucosa

Choe

Warrier

Chun

et al. 2003

J Biomedical Materials Res

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Abstract:The effects of EDTA on the expression and topologic localization of mitogen-activated protein (MAP) kinases (ERK, JNK, and p38), along with nitric oxide synthase (NOS), I-KappaB, and p53 were examined to elucidate the host response provoked by the intravaginal application of a female controlled drug delivery system (FcDDS) containing a spermicidal/microbicidal agent and EDTA. Immunohistochemical and immunoblotting studies were conducted to identify and quantitate the EDTA-inducible proteins in vaginal mucosa. The content of nitrite, which is one of the primary stable breakdown products of nitric oxide (NO), was determined to correlate the expression of NOS with NO formation in HeLa cervical carcinoma cell line. The immunohistochemical study demonstrated that the modulation of the calcium gradient by EDTA activated MAP kinases (ERK and JNK) in the rabbit vaginal mucosa. The results of Western immunoblot study demonstrated differential expression of MAP kinases (ERK and JNK) with EDTA treatment, whereas the expression of NOS and NF-KappaB was not affected by EDTA. There was no significant difference in nitrite production in the HeLa cell line upon exposure to EDTA compared with the control, which was consistent with the results of the Western blot study. The results of this work support that the regulation of MAP kinase was affected by calcium, which is controlled by chelation activity of EDTA. The specific tissue responses exerted by the loading components of a biomaterial-based system should be fully taken into consideration for its intravaginal application.

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Sustained release of piroxicam from solid lipid nanoparticle as an effective anti-inflammatory therapeutics in vivo

Peng

Wei

Shan

et al. 2016

Drug Development and Industrial Pharmacy

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This study aims to investigate the solid lipid nanoparticle (SLN) as a novel vehicle for the sustained release and transdermal delivery of piroxicam, as well as to determine the anti-inflammation effect of piroxicam-loaded SLN. SLN formulation was optimized and the particle size, polydispersity index, zeta potential (ZP), encapsulation efficiency, drug release, and morphological properties were characterized. The transdermal efficiency and mechanism of the piroxicam-loaded SLNs were investigated in vitro. With the inflammation induced edema model in rat, the anti-inflammatory efficiency of piroxicam-enriched SLNs (Pir-SLNs) was evaluated. The SLN formulation was optimized as: lecithin 100 mg, glycerin monostearate 200 mg, and Tween (1%, w/w). The particle size is around 102 ± 5.2 nm with a PDI of 0.262. The ZP is 30.21 ± 2.05 mV. The prepared SLNs showed high entrapment efficiency of 87.5% for piroxicam. There is no interaction between piroxicam and the vehicle components. The presence of polymorphic form of lipid with higher drug content in the optimized Pir-SLNs enables the Pir-SLNs to release the drug with a sustained manner. Pir-SLNs with oleic acid as enhancer can radically diffuse into both the stratum corneum and dermal layer, as well as penetrate through the hair follicles and sebaceous glands with significantly higher density than the other control groups. Pir-SLNs promptly inhibited the inflammation since the 3rd hour after the treatment by decreasing the PGE level. SLN was demonstrated to be a promising carrier for encapsulation and sustained release of piroxicam. Pir-SLN is a novel topical preparation with great potential for anti-inflammation application.

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Abstract: The alteration in the calcium gradient significantly decreased the permeation rate of a hydrophilic drug, such as nicotinic acid.

Cited by 3 publications

References 20 publications

Tinospora cordifolia as medicinal herb

Tinospora cordifolia as medicinal herb

EDTA‐induced activation of Ca‐regulated proteins in the vaginal mucosa

Sustained release of piroxicam from solid lipid nanoparticle as an effective anti-inflammatory therapeutics in vivo

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