Klatskin tumors and �Klatskin-mimicking lesions�: our 22-year experience.

Tsalis, Konstantinos; Parpoudi, Styliani; Kyziridis, Dimitrios; Ioannidis, Orestis; Savvala, Natalia Antigoni; Antoniou, Nikolaos; Symeonidis, Savvas; Konstantaras, Dimitrios; Mantzoros, Ioannis; Pramateftakis, Manousos-Georgios; Kotidis, Efstathios; Angelopoulos, Stamatios

doi:10.17235/reed.2018.5749/2018

Cited by 6 publications

(6 citation statements)

References 25 publications

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“…Дифференциальный диагноз опухоли Клацкина следует проводить с доброкачественными стриктурами, другими первичными и метастатическими новообразованиями. В удаленных на операции фрагментах в 10-15 % наблюдений обнаруживаются доброкачественные заболевания [4,16,17]. В нашем исследовании диагноз холангиокарциномы не подтвердился у 6 больных (11,5 %): у 5 имел место склерозирующий холангит, у одного гемангиоэпителиома печени.…”

Section: Discussionunclassified

Antegrade Endobiliary Forceps Biopsy Improves Diagnosis of Klatskin Tumor Compared to Brush Biopsy

Козлов

Таразов

Поликарпов

et al. 2022

Rossijskij žurnal gastroènterologii, gepatologii, koloproktolog

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Aim. To evaluate the safety and accuracy of percutaneous transhepatic biliary biopsy in patients with suspected Klatskin tumor.Materials and methods. Between 2013–2020, percutaneous transhepatic biliary drainage (PTBD) was performed in 52 patients with Klatskin tumor, complicated by obstructive jaundice. After successful PTBD, the diagnosis was verified by antegrade access. 74 procedures were performed: brush (n = 36; 48.6 %) or forceps biopsies (n = 38; 51.4 %).Results. There were no adverse events associated with a brush biopsy. Only grade I complications were after the forceps technique: 3 patients (7.9 %) developed hemobilia, which was corrected conservatively. Malignant lesions of the biliary tract were detected by forceps technique in 79.0 %, brush biopsy in 66.7 % (p >0,05). The degree of tumor differentiation was determined in 60.0 % (n = 18) vs 12.5 % (n = 3) (p < 0,01), respectively.Sensitivity and specificity of forceps biopsy were slightly higher than in brush: 82.4 % and 75.0 % vs 73.3 % and 66.7 % (p >0,05).Conclusions. Antegrade percutaneous transhepatic biliary biopsy is safe for both brush and forceps techniques. However, forceps biopsy has higher sensitivity and specificity in the diagnosis Klatskin tumor and better possibility of determining the degree of malignancy differentiation.

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Section: Discussionunclassified

Antegrade Endobiliary Forceps Biopsy Improves Diagnosis of Klatskin Tumor Compared to Brush Biopsy

Козлов

Таразов

Поликарпов

et al. 2022

Rossijskij žurnal gastroènterologii, gepatologii, koloproktolog

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“…El diagnóstico diferencial principal es el tumor de Klatskin debido a su similitud de presentación e inespecificidad clínico-radiológica (2,7,10,11) . Aunque de validez controvertida, la concentración sérica de CA 19-9 supone un papel importante con un umbral mayor a 1 000 U/ml para sospecha de malignidad y, menor a 100 U/ml en lesiones benignas como el valor encontrado en nuestra paciente (1) .…”

Section: Discussionunclassified

“…Ello debido a presencia de tejido nervioso central y degeneración mixoide periférica. Este escenario es incongrüente a la imagen hipointensa observada por colangioresonancia magnética del presente caso (1,2,5) .…”

Section: Discussionunclassified

“…El tumor de Klatskin o colangiocarcinoma hiliar es una neoplasia en la confluencia de los conductos hepáticos cuyo diagnóstico erróneo origina resecciones quirúrgicas radicales (1) . Aunque diversas lesiones pueden imitarlo, los tumores neurogénicos que involucran el abdomen (de origen en células ganglionares, paragangliónicas o de la vaina nerviosa) son una causa poco habitual (2) .…”

Section: Introductionunclassified

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Neurofibroma de la vía biliar: una causa rara de ictericia colestásica que imita el tumor de Klatskin

Gómez-Rázuri

Espino-Saavedra

2021

Rev Gastroenterol Peru

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El neurofibroma de la vía biliar es una enfermedad extremadamente rara y generalmente asintomática, sin embargo, puede ocasionar ictericia obstructiva y simular un tumor de Klatskin conduciendo a un tratamiento quirúrgico radical y mayor morbilidad del paciente. Presentamos el caso de una mujer de 62 años colecistectomizada hace 10 años, con ictericia y dolor en hipocondrio derecho, así como exámenes auxiliares compatibles con colestasis. Se observó dilatación de la vía biliar y presencia de un tumor en el conducto hepático izquierdo mediante colangioresonancia magnética. El diagnóstico clínico preoperatorio fue Colangiocarcinoma hiliar, pero el estudio histopatológico reveló una neoplasia compuesta por células fusocelulares sin atipia ni actividad mitótica, cuya estirpe neurogénica se sustentó por su positividad a proteína S100 en inmunohistoquímica. Reportamos el cas ura y su relevancia, al ser una entidad benigna, como diagnóstico diferencial de cáncer.

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“…Retrograde cholangiography can also provide a definitive dia gnosis when combined with tissue bio-Carcinoid (NET G1) tumours of the extrahepatic biliary ducts account for only 0.1-0.2% of all carcinoids of the digestive system [13]. They occur more frequently in young female patients [107]. To date, only 14 patients with hilar NET G1 have been reported in international literature [108].…”

Section: Granular Cell Tumourmentioning

confidence: 99%

Benign Tumours and Pseudotumours Within the Porta Hepatis Masquerading as Perihilar Cholangiocarcinoma

Vasiliadis¹,

Ioannidis²,

Tsalis³

2019

Klin Onkol

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Background: Hilar cholangiocarcinoma (HC), also referred to as Altemeier-Klatskin's tumour, is a lethal primary extrahepatic carcinoma of biliary epithelial origin, aris ing within 2 cm of the hilar confluence. Radical surgical excision provides the best chance for a cure; however, the management of patients with HC is challeng ing not only because of the need for a high level of skill in biliary and hepatic resections, but also because of the difficulty in reach ing an accurate dia gnosis preoperatively. In fact, the differential dia gnosis of HC is a dia gnostic dilemma which is currently persisting, as modern, sophisticated dia gnostic modalities are not always able to provide a definitive preoperative dia gnosis. This difficulty is compounded by the fact that alternative entities that mimic HC may be present in up to 25% of patients with hilar obstruction. This makes precise preoperative characterisation of a hilar stricture extremely important by prevent ing unnecessary, high-risk, major surgical procedures. Therefore, alternative benign entities masquerad ing as Altemeier-Klatskin's tumour deserve an important place in the differential dia gnosis of hilar obstruction. Purpose: Consider ing the important clinical implications that a precise dia gnosis of the aetiological cause of a biliary obstruction at the liver hilum would have, this paper will focus on the differentiation between HC and benign hilar obstructions and will review benign tumours and pseudotumours masquerad ing as HC along with their specific dia gnostic features.

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Klatskin tumors and �Klatskin-mimicking lesions�: our 22-year experience.

Cited by 6 publications

References 25 publications

Antegrade Endobiliary Forceps Biopsy Improves Diagnosis of Klatskin Tumor Compared to Brush Biopsy

Antegrade Endobiliary Forceps Biopsy Improves Diagnosis of Klatskin Tumor Compared to Brush Biopsy

Neurofibroma de la vía biliar: una causa rara de ictericia colestásica que imita el tumor de Klatskin

Benign Tumours and Pseudotumours Within the Porta Hepatis Masquerading as Perihilar Cholangiocarcinoma

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