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Conroy, John F.T.; Power, Mary E.; Martin, Julia H.; Earp, Brian; Hosticka, B.; Daitch, Charles E.; Norris, Pamela M.

doi:10.1023/a:1008704208324

Cited by 56 publications

(39 citation statements)

References 14 publications

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“…These characteristics include high internal surface areas and porosities, as well as production routes that do not require extreme temperatures and are thereby biocompatible, for example, that developed by Conroy et al [6]. In addition, the surface of a silica sol-gel can be functionalized to increase the energy cost associated with non-specific adsorption of DNA.…”

Section: Introductionmentioning

confidence: 99%

“…Biocompatible silica gels can be formed in a two-step gel formation process that yields silica gels having an almost entirely aqueous interstitial fluid, rather than the ethanol produced by traditional sol-gel methods [6,7]. The first step in the gel formation process is hydrolysis of an alkoxysilane such as tetraethoxysilane (TEOS) in a low pH aqueous solution.…”

Section: Introductionmentioning

confidence: 99%

“…The first step in the gel formation process is hydrolysis of an alkoxysilane such as tetraethoxysilane (TEOS) in a low pH aqueous solution. This hydrolysis yields various silicates that are sufficiently polar to dissolve in a largely aqueous solvent [6]. Conroy et al recommend the use of an aqueous nitric acid solution to catalyze the hydrolysis [6].…”

Section: Introductionmentioning

confidence: 99%

“…This hydrolysis yields various silicates that are sufficiently polar to dissolve in a largely aqueous solvent [6]. Conroy et al recommend the use of an aqueous nitric acid solution to catalyze the hydrolysis [6]. Here, however, propyltrichlorosilane (PTS) replaced nitric acid as the catalyst, since a molar equivalent of HCl is released by hydrolysis of PTS in water.…”

Section: Introductionmentioning

confidence: 99%

“…Here, however, propyltrichlorosilane (PTS) replaced nitric acid as the catalyst, since a molar equivalent of HCl is released by hydrolysis of PTS in water. After the TEOS was hydrolyzed and the hydrolysis products dissolved in the aqueous solvent, the solution temperature was increased to 85°C and an open-pot distillation was performed for 1 h to remove hydrolysis reaction product ethanol [6]. The second step in the gel formation process involves an increase in the pH of the acidic sol using NaOH to catalyze gelation.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

The design and testing of a silica sol–gel-based hybridization array

Phinney

Conroy

Hosticka

et al. 2004

Journal of Non-Crystalline Solids

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

The design and testing of a silica sol–gel-based hybridization array

Phinney

Conroy

Hosticka

et al. 2004

Journal of Non-Crystalline Solids

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Biocers, Industrial Applications

Coradin

Amoura

Roux

et al. 2009

Encyclopedia of Industrial Biotechnology

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After 20 years of research, the inorganic sol–gel process can now be considered as a suitable technological alternative for the encapsulation of living cells. Strategies have been developed and optimized that allow the formation of glasses and ceramics in conditions compatible with the preservation of cell membrane integrity and metabolic activity over several weeks. These biocer(amic)s can be prepared as gels, coatings, films, and capsules, which can host a wide variety of organisms including bacteria, protists, yeasts, and plant and animal cells. It was demonstrated that biocers can be used for the design of bioreactors, biosensors, as well as for bioremediation systems, at least at the laboratory scale. Moreover, hybrid materials associating biopolymers and silica were shown to be suitable for the elaboration of bioartificial organs that have been patented and are currently under clinical evaluation. The biocer technology has now reached its maturity, suggesting that industrial developments can now be foreseen in the near future.

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Biomimetic Coatings to Control Cellular Function through Cell Surface Engineering

Drachuk

Gupta

Tsukruk

2013

Adv Funct Materials

111

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Biologically inspired materials and structures with tailored biological, physical, and chemical properties provide an indispensable platform to actively modulate and protect cell function in hostile and synthetic environments (e.g., devices or matrices). Herein, recent innovations are discussed in cell surface engineering methods based on bulk hydrogels, microgels, and ultrathin capsules derived from inorganic, polymeric, biomolecular, or nanoparticle materials applicable to various protective and interaction mediating applications. These biomimetic cell coatings can dramatically increase cell viability and stability in a hostile environment and expand their applicability for demanding biomedical, biotechnology, and bioelectronics applications. Some of the most recent studies of traditional inorganic and organic gels, polymeric and biomolecular microgels, and ultrathin conformal soft shells from polymers and proteins are also discussed. Proper selection of chemical composition and assembly conditions has potential to dramatically enhance viability of encapsulated cells by increasing their mechanical stability, masking the cell surface from immunological agents, increasing mechanical stability, and providing chemical resistance to aggressive environments. Some recent examples of such robust and viable protected cells for biotechnology and bioelectronics are presented.

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Cited by 56 publications

References 14 publications

The design and testing of a silica sol–gel-based hybridization array

The design and testing of a silica sol–gel-based hybridization array

Biocers, Industrial Applications

Biomimetic Coatings to Control Cellular Function through Cell Surface Engineering

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