Klebsiella ESBL bacteremia-mortality and risk factors

Empirical treatment and mortality in bacteremia due to extended spectrum β-lactamase producing Enterobacterales (ESβL-E), a retrospective cross-sectional study in a tertiary referral hospital from Colombia

“…In our cohort there was a high prevalence of risk factors for healthcare-associated infections and the group that died due to sepsis was more compromised in their health status: they were most commonly affected by septic shock, they had higher admission to critical care, they had higher requirement of ventilatory support and they had higher Pitt bacteremia score; therefore, based on current recommendations [ 21 , 22 ], these patients should have received a higher proportion of treatment with carbapenems, however only 43% of this group received it. Similar findings were reported by Tuon et al, where the authors found that only 52% received adequate treatment within 48 h of bacteremia [ 19 ].…”

“…Many scientific publications have reported different levels of mortality in BSI caused by ESβL-E. In most reports, mortality is high, but with a wide range, for example, Lim et al reported a 20% mortality [ 10 ] but, Namikawa et al reported a 9.7% mortality [ 17 ], Scheuerman et al reported an ESβL-producing K. pneumoniae BSI mortality of 33% and, an ESβL-producing E. coli BSI mortality of 17% [ 18 ], also, Tuon et al reported a mortality from ESβL-producing K. pneumoniae of 49% [ 19 ]. The enormous heterogeneity that exists between the characteristics of the population of each mortality report may explains this notable variation in mortality from ESβL.…”