2013
DOI: 10.1111/j.1469-0691.2012.03805.x
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Klebsiella pneumoniae resistant to third-generation cephalosporins in five African and two Vietnamese major towns: multiclonal population structure with two major international clonal groups, CG15 and CG258

Abstract: The molecular epidemiology of third-generation cephalosporin-resistant (3GC-R) Klebsiella pneumoniae in developing countries is poorly documented. From February 2007 to March 2008, we collected 135 3GC-R K. pneumoniae isolates from seven major towns in Maghreb (Morocco), West Africa (Senegal, Côte d'Ivoire), Central Africa (Cameroon), East Africa (Madagascar) and Southeast Asia (Vietnam). Their genetic diversity, assessed by multilocus sequence typing, was high (60 sequence types), reflecting multiclonality. H… Show more

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Cited by 107 publications
(106 citation statements)
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“…In the last two decades, outbreaks of infections caused by extended-spectrum blactamase (ESBL)-producing Enterobacteriaceae have largely been reported [9,10]. Among other ESBL producers, Escherichia coli and Klebsiella pneumoniae have been implicated as the main gram-negative bacteria that are associated with production of these enzymes which are responsible for multi-drug resistance [11,12,13].…”
Section: Introductionmentioning
confidence: 99%
“…In the last two decades, outbreaks of infections caused by extended-spectrum blactamase (ESBL)-producing Enterobacteriaceae have largely been reported [9,10]. Among other ESBL producers, Escherichia coli and Klebsiella pneumoniae have been implicated as the main gram-negative bacteria that are associated with production of these enzymes which are responsible for multi-drug resistance [11,12,13].…”
Section: Introductionmentioning
confidence: 99%
“…The major international high-risk clones identified by MLST belong to sequence type 11 (ST11), ST15, ST147,. ST11 and ST258 were included in clonal group (CG) 258 (11,14), while ST15 and ST147 were grouped in CG15 and CG147 (11, 13, 14), respectively.High-level carbapenem resistance in K. pneumoniae may develop via the loss of the OmpK36 porin coupled with the expression of various ␤-lactamases (17-19). The OmpK36 porin in K. pneumoniae may also play a role in bacterial virulence (18).…”
mentioning
confidence: 99%
“…The major international high-risk clones identified by MLST belong to sequence type 11 (ST11), ST15, ST147,. ST11 and ST258 were included in clonal group (CG) 258 (11,14), while ST15 and ST147 were grouped in CG15 and CG147 (11, 13, 14), respectively.…”
mentioning
confidence: 99%
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“…Therefore, the scenario obtained here was only the consequences of the physicians' biases and/or the market policy of pharmaceutical companies to a particular antibiotic. The prescribed antibiotics for POI were β-lactum group (penicillin and cephalosporin) but cephalosporin resistance has been reported in many cities of developing countries (Bhattacharya et al, 2011;Alvarez-Uria et al, 2010;Breurec et al, 2013;Reardon, 2014;Bharara et al, 2015) including Rajshahi city, Bangladesh (Chouduri and Wadud, 2013;Chouduri and Wadud, 2014;Rashid and Rahman, 2014). Also recently in developed countries, cephalosporin resistance in gonorrhea has been reported (Kirkcaldy et al, 2013).…”
Section: Antibiotic Use In the Community Against Diseasesmentioning
confidence: 99%