Klebsiella pneumoniae Virulence Factors and Biofilm Components: Synthesis, Structure, Function, and Inhibitors

Joseph, Bicky Jerin; Mathew, Maya; Rachel, Riya; Mathew, Jyothis; Radhakrishnan, E. K.

doi:10.1007/978-981-99-8799-3_9

ESKAPE Pathogens 2024

DOI: 10.1007/978-981-99-8799-3_9

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Klebsiella pneumoniae Virulence Factors and Biofilm Components: Synthesis, Structure, Function, and Inhibitors

Bicky Jerin Joseph,

Maya Mathew,

Riya Rachel

et al.

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2024

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Pulsed electric field at resonance frequency combat Klebsiella pneumonia biofilms

Mohamed,

Mohammed,

El-Gebaly

et al. 2024

Appl Microbiol Biotechnol

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Healtcare-associated infections have increased due to the development of antimicrobial resistance (AMR) of Gram-negative pathogens (GNPs) and the development of outbreacks over the past two decades. In this work, we investigated how exposure to positive electric pulses affects the growth characteristics of Klebsiella pneumonia (K. pneumonia), a common cause of pneumonia. We explored the impact of varying exposure frequencies (0.2–2 Hz) and time (15–90 min, at resonance frequency) on bioelectric signals produced during cell division, biofilm formation, and bacterial antibiotic susceptibility. Our research found that an extremely low-frequency pulsed electric field (ELF-PEF) significantly inhibited K. pneumonia growth. Specifically, exposure to 0.8 Hz for one hour increased the antibiotic susceptibility of K. pneumonia to inhibitors of cell wall formation, proteins, β-lactamase, DNA, and other substances. We also noticed a notable decrease in K. pneumonia biofilm development exposed to ELF-PEF. Our results suggest that the interaction of K. pneumonia cells with ELF-PEF at the specified frequency and time alters cellular activity and bacterial structure. This technique may be used in the future to treat K. pneumonia infections both in vitro and in vivo.

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Pulsed electric field at resonance frequency combat Klebsiella pneumonia biofilms

Mohamed,

Mohammed,

El-Gebaly

et al. 2024

Appl Microbiol Biotechnol

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Klebsiella pneumoniae Virulence Factors and Biofilm Components: Synthesis, Structure, Function, and Inhibitors

Cited by 1 publication

References 99 publications

Pulsed electric field at resonance frequency combat Klebsiella pneumonia biofilms

Pulsed electric field at resonance frequency combat Klebsiella pneumonia biofilms

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