2015
DOI: 10.1093/gbe/evv141
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KLF/SP Transcription Factor Family Evolution: Expansion, Diversification, and Innovation in Eukaryotes

Abstract: The Krüppel-like factor and specificity protein (KLF/SP) genes play key roles in critical biological processes including stem cell maintenance, cell proliferation, embryonic development, tissue differentiation, and metabolism and their dysregulation has been implicated in a number of human diseases and cancers. Although many KLF/SP genes have been characterized in a handful of bilaterian lineages, little is known about the KLF/SP gene family in nonbilaterians and virtually nothing is known outside the metazoan… Show more

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Cited by 104 publications
(113 citation statements)
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“…Currently, the 9aaTAD family comprises over 40 members including Gal4, Oaf1, Pip2, Pdr1, Pdr3, Leu3, Tea1, Pho4, Gln3, Gcn4, Msn2, Msn4, Rtg3, E2A, MLL, p53-TAD-I, p53-TAD-II, HNF4 / NHR-49, FOXO3, NF-kB, NFAT, CEBPA/E, ESX, ELF3, ETV1, KLF2/4, EBNA2, VP16, HSF1, HSF2, HsfA, Gli3, Sox18, PIF, Dreb2a, MTF1, OREB1, WRKY45, NS1, MKL1, TRP32, VP16, EBNA2, KBP220, ECapLL, P201, AH, and B42 transcription factors. We and others have shown that the activation domains 9aaTAD have competence to activate transcription as small peptides [32,33,36,6680]. The activation domains 9aaTAD are annotated on protein database UniProt (http://www.uniprot.org/uniprot/?query=9aatad&sort=score) and the 9aaTAD prediction service is available online (www.piskacek.org).…”
Section: Discussionmentioning
confidence: 99%
“…Currently, the 9aaTAD family comprises over 40 members including Gal4, Oaf1, Pip2, Pdr1, Pdr3, Leu3, Tea1, Pho4, Gln3, Gcn4, Msn2, Msn4, Rtg3, E2A, MLL, p53-TAD-I, p53-TAD-II, HNF4 / NHR-49, FOXO3, NF-kB, NFAT, CEBPA/E, ESX, ELF3, ETV1, KLF2/4, EBNA2, VP16, HSF1, HSF2, HsfA, Gli3, Sox18, PIF, Dreb2a, MTF1, OREB1, WRKY45, NS1, MKL1, TRP32, VP16, EBNA2, KBP220, ECapLL, P201, AH, and B42 transcription factors. We and others have shown that the activation domains 9aaTAD have competence to activate transcription as small peptides [32,33,36,6680]. The activation domains 9aaTAD are annotated on protein database UniProt (http://www.uniprot.org/uniprot/?query=9aatad&sort=score) and the 9aaTAD prediction service is available online (www.piskacek.org).…”
Section: Discussionmentioning
confidence: 99%
“…Conversely, the amino-terminal regions of KLFs are divergent and modulate the specificity of protein-protein and protein-DNA interactions (Nagai et al, 2009). Recently, comprehensive evolutionary studies of SP/KLF family members using zinc finger sequences as well as transactivation/repression domains for phylogenetic analysis confirmed the existence of this family in 48 species within Eukaryota (Presnell et al, 2015); the evolutionary relationships between KLFs of murine and human origin based on their zinc finger domains is outlined in Fig. 2 The specificity of KLF-mediated transcriptional activation is defined mostly by their N-terminal sequences.…”
Section: Introductionmentioning
confidence: 94%
“…Members of the KLF family also share structural homology and DNA-binding capacity with specificity proteins (SPs) and are thus often referred to as SP/ KLF transcription factors. Recent studies have shown that specific KLFs are expressed across many species, spanning from single-celled to multicellular organisms (Presnell et al, 2015). Importantly, since their discovery, KLFs have been implicated in a variety of physiological processes, acting to regulate key cellular functions such as proliferation, differentiation and apoptosis.…”
Section: Introductionmentioning
confidence: 99%
“…KLF proteins can be grouped into clades according to their N-terminal domains ( Figure 2) (Presnell et al, 2015). Klf1, Klf2, and Klf4 primarily activate target genes by recruiting cofactors such as p300…”
Section: Common Structures Of Klfsmentioning
confidence: 99%
“…The Specificity Protein (SP) family of proteins are related to the KLFs (Suske et al, 2005) and bind similar motifs in vivo (Volkel et al, 2015). SP/KLF proteins can be grouped into clades according to their Nterminal domains ( Figure 5.1A) (Presnell et al, 2015). Krüppel-like factor 1 (KLF1), KLF2, and KLF4 primarily activate target genes by recruiting cofactors such as EP300 and CBP (Zhang et al, 2001), whereas KLF3, KLF8, and KLF12 repress target genes by recruiting cofactors such as Cterminal binding proteins (CtBP1, CtBP2) (Dewi et al, 2015, Turner & Crossley, 1998, van Vliet et al, 2000.…”
Section: Introductionmentioning
confidence: 99%