KLF5 Is Activated by Gene Amplification in Gastric Cancer and Is Essential for Gastric Cell Proliferation

Chen, Wei; Zhang, Jian; Fu, Huafeng; Xu, Hongguo; Qiao, Shan; Yang, Dongjie

doi:10.3390/cells10051002

Cited by 13 publications

(8 citation statements)

References 35 publications

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“…Previous research has shown that members of the KLF family are overexpressed in tumor tissues or cell lines. KLF5 overexpression has been discovered in gastric cancer, and it has been linked to greater tumor sizes and later tumor (T) stages [ 18 ]. KLF8 was shown to be overexpressed in human HCC cell lines and samples from individuals with the disease [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

Expression and Prognosis Value of the KLF Family Members in Colorectal Cancer

Huang

Qiu

et al. 2022

Journal of Oncology

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Krüppel-like factors (KLFs) are some kind of transcriptional regulator that regulates a broad range of cellular functions and has been linked to the development of certain malignancies. KLF expression patterns and prognostic values in colorectal cancer (CRC) have, however, been investigated rarely. To investigate the differential expression, predictive value, and gene mutations of KLFs in CRC patients, we used various online analytic tools, including ONCOMINE, TCGA, cBioPortal, and the TIMER database. KLF2-6, KLF8-10, KLF12-15, and KLF17 mRNA expression levels were dramatically downregulated in CRC tissues, but KLF1, KLF7, and KLF16 mRNA expression levels were significantly elevated in CRC tissues. According to the findings of Cox regression analysis, upregulation of KLF3, KLF5, and KLF6 and downregulation of KLF15 were linked with a better prognosis in CRC. For functional enrichment, our findings revealed that KLF members are involved in a variety of cancer-related biological processes. In colon cancer and rectal cancer, KLFs were also shown to be associated with a variety of immune cells. The findings of this research reveal that KLF family members’ mRNA expression levels are possible prognostic indicators for patients with CRC.

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Section: Discussionmentioning

confidence: 99%

Expression and Prognosis Value of the KLF Family Members in Colorectal Cancer

Huang

Qiu

et al. 2022

Journal of Oncology

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“…In gastric cancer, GATA6 has been shown to cooperate with other TFs, such as KLF5, to promote cancer development [ 34 , 35 ]. In CRC, GATA6 and Krüppel-like factor 5 (KLF5) have been implicated in the regulation of cancer stem cell characteristics and chemoresistance [ 36 , 37 ]. Signal transducer and activator of transcription 3 (STAT3) is a TF involved in various cellular processes, including cell growth, differentiation, and survival.…”

Section: Discussionmentioning

confidence: 99%

Unraveling molecular similarities between colorectal polyps and colorectal cancer: a systems biology approach

Radak,

Fallahi

2024

Intest Res

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Background/Aims: Colorectal cancer (CRC) and colorectal polyps are intimately linked, with polyps acting as precursors to CRC. Understanding the molecular mechanisms governing their development is crucial for advancing diagnosis and treatment. Employing a systems biology approach, we investigated the molecular similarities between polyp and CRC. Methods: We analyzed gene expression profiles, protein-protein interactions, transcription factors, and gene ontology to identify common differentially expressed genes (DEGs) and unravel shared molecular pathways. Results: Our analysis revealed 520 commonly dysregulated genes in polyps and CRC, serving as potential biomarkers and pivotal contributors to disease progression. Gene ontology analysis elucidated distinct biological processes associated with upregulated and downregulated DEGs in both conditions, highlighting common pathways, including signal transduction, cell adhesion, and positive regulation of cell proliferation. Moreover, protein-protein interaction networks shed light on subnetworks involved in rRNA processing, positive regulation of cell proliferation, mRNA splicing, and cell division. Transcription factor analysis identified major regulators and differentially expressed transcription factors in polyp and CRC. Notably, we identified common differentially expressed transcription factors, including ZNF217, NR3C1, KLF5, GATA6, and STAT3, with STAT3 and NR3C1 exhibiting increased expression. Conclusions: This comprehensive analysis enriches our understanding of the molecular mechanisms underlying polyp formation and CRC development, providing potential targets for further investigation and therapeutic intervention. Our findings contribute substantively to crafting personalized strategies for refining the diagnosis and treatment of polyps and CRC.

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“…Notably, Chinese institutions formed closer collaborations within the country than with external agencies. Chinese researchers are characterized by a lack of influence, which may be attributed to the lack of external collaboration(s), thus necessitating encouragement to form partnerships with institutions around the world[ 33 , 34 ].…”

Section: Discussionmentioning

confidence: 99%

Bibliometrics analysis based on the Web of Science: Current trends and perspective of gastric organoid during 2010-2023

Jiang,

Jia,

Liu

et al. 2024

World J Gastroenterol

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BACKGROUND Three-dimensional organoid culture systems have been established as a robust tool for elucidating mechanisms and performing drug efficacy testing. The use of gastric organoid models holds significant promise for advancing personalized medicine research. However, a comprehensive bibliometric review of this bur-geoning field has not yet been published. AIM To analyze and understand the development, impact, and direction of gastric organoid research using bibliometric methods using data from the Web of Science Core Collection (WoSCC) database. METHODS This analysis encompassed literature pertaining to gastric organoids published between 2010 and 2023, as indexed in the WoSCC. CiteSpace and VOSviewer were used to depict network maps illustrating collaborations among authors, institutions and keywords related to gastric organoid. Citation, co-citation, and burst analysis methodologies were applied to assess the impact and progress of research. RESULTS A total of 656 relevant studies were evaluated. The majority of research was published in gastroenterology-focused journals. Globally, Yana Zavros, Hans Clevers, James M Wells, Sina Bartfeld, and Chen Zheng were the 5 most productive authors, while Hans Clevers, Huch Meritxell, Johan H van Es, Marc Van de Wetering, and Sato Toshiro were the foremost influential scientists in this area. Institutions from the University Medical Center Utrecht, Netherlands Institute for Developmental Biology (Utrecht), and University of Cincinnati (Cincinnati, OH, United States) made the most significant contributions. Currently, gastric organoids are used mainly in studies investigating gastric cancer (GC), Helicobacter pylori -infective gastritis, with a focus on the mechanisms of GC, and drug screening tests. CONCLUSION Key focus areas of research using gastric organoids include unraveling disease mechanisms and enhancing drug screening techniques. Major contributions from renowned academic institutions highlight this field’s dynamic growth.

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KLF5 Is Activated by Gene Amplification in Gastric Cancer and Is Essential for Gastric Cell Proliferation

Cited by 13 publications

References 35 publications

Expression and Prognosis Value of the KLF Family Members in Colorectal Cancer

Expression and Prognosis Value of the KLF Family Members in Colorectal Cancer

Unraveling molecular similarities between colorectal polyps and colorectal cancer: a systems biology approach

Bibliometrics analysis based on the Web of Science: Current trends and perspective of gastric organoid during 2010-2023

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