2024
DOI: 10.1093/biolre/ioae076
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Klinefelter syndrome: etiology and clinical considerations in male infertility

Xinyue Chen,
Xueguang Zhang,
Ting Jiang
et al.

Abstract: Klinefelter syndrome (KS) is the most prevalent chromosomal disorder occurring in males. It is defined by an additional X chromosome, 47,XXY, resulting from errors in chromosomal segregation during parental gametogenesis. A major phenotype is impaired reproductive function, in the form of low testosterone and infertility. This review comprehensively examines the genetic and physiological factors contributing to infertility in KS, in addition to emergent assisted reproductive technologies, and the unique ethica… Show more

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