Klinefelter Syndrome: Predisposition to Acute Non-Lymphocytic Leukæmia?

Geraedts, J. P. M.; Ford, C. E.; Briët, E.; Hartgrink-Groeneveld, C.A.; Ottolander, G. J. den

doi:10.1016/s0140-6736(80)91539-1

Cited by 15 publications

(1 citation statement)

References 3 publications

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“…A cohort study of 3518 men with KS revealed increased risk of lung cancer, breast cancer and non-Hodgkin lymphoma, while a decreased risk of prostate cancer (110). Contrary to an anecdotal report (111), there was no statistically significant increase in the incidence of leukemia. The lower risk for prostate cancer is in accordance with a Danish cohort (112).…”

Section: Aneuploidies Of the Sex Chromosomesmentioning

confidence: 78%

Constitutional aneuploidy and cancer predisposition

Ganmore

Smooha

Izraeli

2009

Human Molecular Genetics

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Constitutional aneuploidies are rare syndromes associated with multiple developmental abnormalities and the alterations in the risk for specific cancers. Acquired somatic chromosomal aneuploidies are the most common genetic aberrations in sporadic cancers. Thus studies of these rare constitutional aneuploidy syndromes are important not only for patient counseling and clinical management, but also for deciphering the mechanisms by which chromosomal aneuploidy affect cancer initiation and progression. Here we review the major constitutional aneuploidy syndromes and suggest some general mechanisms for the associated cancer predisposition.

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Section: Aneuploidies Of the Sex Chromosomesmentioning

confidence: 78%

Constitutional aneuploidy and cancer predisposition

Ganmore

Smooha

Izraeli

2009

Human Molecular Genetics

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Karyotypic progression in human tumors

Wolman

1983

Cancer Metast Rev

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Karyotypic progression may be viewed in at least two ways. One approach seeks evidence for increasing and progressive deviation from the normal chromosome pattern in tumors. The clearest examples, found in some leukemias, are those in which successive karyotypic changes are superimposed on an already aberrant cell population. Evidence of chromosomal progression within solid tumors is far less frequent, possibly because the tumors themselves are at a relatively late stage in their evolution. An alternative approach, therefore, attempts to correlate the extent of karyotypic deviation with other aspects of tumor progression. Recent data, based on classical cytogenetic analyses and flow cytometry, are presented to determine relationships between karyotype and specific origin and morphology of tumors. The predominant theme which emerges, not surprisingly, is that the more deviant chromosome patterns are associated with other measures of increased biologic malignancy. What is surprising is the degree to which these properties are expressed in primary tumors and the relative lack of evidence for further karyotypic evolution with recurrence or metastasis. Examples of genetic instability, evolution through polyploidy, gene amplification, and selection for specific chromosomal rearrangement are found in populations of premalignant and malignant human cells. There is increasing recognition of the importance of tumor-specific chromosome aberrations in the stepwise progression from the normal to the fully neoplastic cell.

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Klinefelter's syndrome and acute non-lymphocytic leukemia

Muts-Homsma

Müller

Geraedst

1982

Blut

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In five out of 51 adult, male patients with acute non-lymphocytic leukemia, Klinefelter's syndrome was demonstrated karyotypically. The incidence of this syndrome in our material is very much increased in comparison with the frequency at birth. In this article the medical histories of the patients are given and the possible connection between the constitutional chromosome abnormality and acute non-lymphocytic leukemia is discussed. Immunological or hormonal abnormalities or an increased virus susceptibility might be predisposing factors.

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Klinefelter Syndrome: Predisposition to Acute Non-Lymphocytic Leukæmia?

Cited by 15 publications

References 3 publications

Constitutional aneuploidy and cancer predisposition

Constitutional aneuploidy and cancer predisposition

Karyotypic progression in human tumors

Klinefelter's syndrome and acute non-lymphocytic leukemia

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