Kliniğimizde 1992–2011 yılları arasında akut bakteriyel menenjit tanısıyla yatarak tedavi gören hastalarda erken komplikasyonlarla ilişkili etmenler

Abstract

Aim: To evaluate factors associated with the development of early complications in acute bacterial meningitis. Material and Methods: In our study, 389 patients diagnosed with acute bacterial meningitis between January 1992 and January 2011 at Cerrahpaşa Medical Faculty were retrospectively analyzed to determine the risk factors for the development of early complications. Results: The causative agent was N. meningitidis in 17% of cases, S. pneumoniae in 13.6%, and H. influenzae type b in 6.4%. In 55.5% of cases, the causative agent could not be identified. The mortality rate was found as 1% and the early complication rate was 27.8%. The complications observed included septic shock and disseminated intravascular coagulation (33.3%), hydrocephalus (23.1%), subdural effusion (19.4%), and epilepsy (12%). Risk factors for early complications included being aged below two years (p<0.010), restlessness (p<0.010), rash (p<0.010), leukocytosis in complete blood count (p<0.010), and a cerebrospinal fluid glucose level of <45 mg/dL (p<0.010). Three of the four patients who died were male. The incidence of hydrocephalus was higher in patients who used ampicillin-cefotaxime and who did not receive steroid therapy before treatment (p<0.050). Conclusion: When acute bacterial meningitis is treated properly and adequately, recovery without sequela is possible. Knowing the risk factors for early complications will guide in the monitoring of patients and decrease morbidity and mortality rates.

Global Burden and Its Association with Socioeconomic Development Status of Meningitis Caused by Specific Pathogens over the Past 30 years: A Population-Based Study

“…Meningitis is a severe, fatal disease that can cause permanent brain damage, death, and severe, long-term neurological sequelae [1][2][3]. Despite the availability of meningitis vaccines and antibiotics to prevent and treat meningitis, the current global burden of meningitis remains high, and meningitis is both a large component of the global neurological burden and a noteworthy cause of death among children worldwide [4][5][6][7][8][9][10].…”