Klinik, Diagnostik und Therapie HIV-induzierter neuropsychiatrischer Störungen

Abstract

Since the acquired immune deficiency syndrome (AIDS) was first recognized in 1981, more than 25 million individuals have died from complications of the human immunodeficiency virus (HIV) infection. The introduction of highly active antiretroviral therapy (HAART) in 1995 has resulted in a significantly decreased incidence rate of AIDS in the developed world. As HAART led to considerable improvements in survival for patients with HIV infection, HIV-neurotropically associated neuropsychiatric disorders have become an increasingly important challenge for clinical medicine. This article gives an overview of epidemiology, clinical features, diagnosis, and therapy of HIV-induced cognitive-motor impairments including HIV-associated dementia complex, organic mood disorders and psychosis.

Depression associated with antiretroviral drug therapy in HIV: case report and overview

“…Genetic predisposition, HAND, opportunistic cerebral infections, as well as reactive depression and non-HIV factors have to be considered. 14,6,15 Here, we report an HIV-infected patient who suffered from three consecutive episodes of major depression, each associated with commencement of a different cART regimen. The patient's personal and family history of a bipolar affective disorder may have been a predisposing factor.…”

“…Genetic predisposition, HAND, opportunistic cerebral infections, as well as reactive depression and non-HIV factors have to be considered. 14,6,15…”

Diagnostik und Psychopharmakotherapie depressiver Erkrankungen bei Herz-Kreislauf-Patienten vor konsiliarpsychiatrischem Hintergrund

“…In Tabelle [8,19]. Unter Abwägung des Nutzen-Risiko-Verhältnisses sollten aus heutiger Sicht TZA bei kardiovaskulär erkrankten Patienten mit Begleitdepression nicht mehr verwendet werden, da sie potenziell kardiotoxisch wirken [25,26].…”