Klinik und Immunpathologie bei 48 Patienten mit Pemphigus

Abstract

Our results confirm the correlation of the autoantibody profile with the clinical phenotype of pemphigus.

Monitoring disease activity in pemphigus with enzyme-linked immunosorbent assay using recombinant desmogleins 1 and 3

“…[3][4][5][6][7][8] These ELISAs have also been shown to be useful for monitoring disease status, 3,4,9-11 but we have had occasion, recently, to consider patients with hightitre antibodies whose index values in these ELISAs did not necessarily parallel observed disease activity. [3][4][5][6][7][8] These ELISAs have also been shown to be useful for monitoring disease status, 3,4,9-11 but we have had occasion, recently, to consider patients with hightitre antibodies whose index values in these ELISAs did not necessarily parallel observed disease activity.…”

“…clinics. [3][4][5][6][7][8] These ELISAs have also been shown to be useful for monitoring disease status, 3,4,[9][10][11] but we have had occasion, recently, to consider patients with hightitre antibodies whose index values in these ELISAs did not necessarily parallel observed disease activity. The ELISA is based on an enzyme reaction.…”

“…3,4 These assays have proved to be a sensitive and specific diagnostic tool for pemphigus, and they are now widely used in dermatology practice. [5][6][7][8] In addition, ELISA scores have been shown to fluctuate in parallel with the time course of disease activity. 3,4,[9][10][11] Since the development of these assays, however, we have found some cases of pemphigus with a high titre of autoantibodies that did not show an apparent decline in ELISA index values after clinical improvement.…”

Immunopathology and molecular diagnosis of autoimmune bullous diseases

“…Cloning of desmoglein 1 and 3 cDNA enabled the development of a sensitive and specific ELISA and extensive characterization of the autoreactivity against these antigens in pemphigus patients [16]. Serum levels of autoantibodies detected by ELISA strongly correlate with disease activity in pemphigus patients [16,17]. The development of commercially available diagnostic tools for the remainder of the autoantigens in pemphigus should facilitate their further characterization in pemphigus patients with regard to reactivity of specific autoantibodies and patterns in disease and remission.…”

Bullöse Autoimmundermatosen (I): Pathogenese und Diagnostik

“…One group shows only lesions on oral mucous membranes and autoantibodies to desmoglein 3, while the other group presents with lesions on both mucous membranes and skin and with autoantibodies to both desmoglein 3 and 1 (modified fromHahn et al, 2000). a) By indirect immunofluorescence microscopy on monkey esophagus, the autoantibodies show an intercellular binding pattern (´250).…”