Klinik und Therapie der gestörten intrapulmonalen Atemmechanik

Fruhmann, G

doi:10.1007/bf02093554

Cited by 3 publications

(2 citation statements)

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“…The abso lute values of airway resistance correspond exactly. In normal subjects airway resistance has been found to be between 0.6 and 2.4, clearly pa thological values beginning with 3.0, 3.5 or even 5.0 cm H20/l/sec accord ing to different authors [2,5,6,8,17,28,33]. This is exactly congruent with the mean 1.5 (0.6-2.8) cm H20/l/sec/Iung in our series.…”

Section: Discussionsupporting

confidence: 81%

“…Spirometry, particularly analysis of forced expiration and pressure-volume loops on the basis of esophageal pressure measurements have increased our knowledge [5,7,20,26,30,32,35]. Alveolar pressure and hence airway resistance have been made measurable directly by body plethysmography [2,6,8,28,31,33]. The newly developed catheter techniques for intrabronchial pressure measure ments have given further information on types and localization of bron chial stenosis [17,20,22], The same techniques can be applied to isolated lungs [10,11,14,21].…”

Section: Discussionmentioning

confidence: 99%

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Distribution of Resistances in Artificially Ventilated Human Autopsy Lungs

Hartung¹,

Kissler²

1970

Respiration

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In artificially ventilated normal and diseased human lungs the distribution of resistances along the airways, between different parts of the lungs, and within emphysematous lesions has been measured and the percentages of elastic and non-elastic tissue and airway resistances calculated. Besides volume, flow, and pleural pressure within the respirator box up to three alveolar catheters, intrabronchial side and end pressure and tracheal catheters have been used to differentiate transpulmonary pressure into its components. Standard ventilation conditions for quiet breathing have been defined as FRC = 50 % TC (TC = V at p = 15 cm H₂O), breathing volume of about 10 % TC, and breathing frequency = 13-15/min which approximately equals in- and expiratory peak flow rates of about 0.2-0.3 1/sec/lung.Airway resistance was 1.57 (0.6-2.8) in normal and 18.43 (3.0-48.0) cm H₂O/l/sec/ lung in emphysematous lungs. Total resistance (Ppi-Pn·) could be differentiated into elastic resistance 72 %, airway resistance 16 %, and tissue resistance 12 %. In disease, particularly in bronchitis and emphysema, there was a marked change of these percentages with elastic resistance considerably lowered to a mean of 33 % and airway resistance increased to 38 %, in severe cases even up to 76 %. Tissue resistance was relatively high with mean values of about 40 % of non-elastic resistances.In normal lungs the directly measured alveolar pressures correspond at various sites, while in disease differences of regional alveolar pressures indicate inhomogeneity of resistances and ventilation. In emphysema three types of ‘closed’, ‘open’, and ‘half-open’ bullous lesions have been established. In half-open lesions the pressure levels lie between pleural and alveolar pressure of the surrounding lung tissue and thus may play a part in the formation of bullae. Moreover in emphysema the increase of airway resistance is caused mostly by the peripheral airways, but in some cases narrowing of the larger airways seems to play a part even in quiet or slightly reinforced breathing. In preparations of both lungs the resistance of the lower trachea limits flow, with the effect that the correction factor for airway resistance and dynamic compliance between one and both lungs is only 1.6 instead of 2.

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Section: Discussionsupporting

confidence: 81%