Klinik und Therapie der Glomerulonephritiden

Reubi, F

doi:10.1007/978-3-642-95038-4_19

Cited by 4 publications

(3 citation statements)

References 191 publications

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“…The increase o f RPF could be explained by the presence of a hyperkinetic circulation associated with anemia [8], as shown in similar circumstances [5], when a temporary nor malization of the parameters was also achieved following a blood transfusion. On the other hand, also in subjects with higher RPF values, the RBF, obtained in accordance with the peripheral venous hematocrit value, appeared to be nearer to the norm, confirming the importance of the anemic state in the genesis of these results.…”

Section: Discussionmentioning

confidence: 99%

Function of the Kidney in Adult Patients with Cooley’s Disease

Mastrangelo¹,

Lopez²,

Rizzelli³

et al. 1975

Nephron

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The function of the kidney in adult subjects with Cooley’s disease has been hitherto inadequately investigated. In 10 patients suffering from thalassemia major, glomerular filtration rate, renal plasma flow, renal blood flow have been studied, together with urine concentration capacity. The authors emphasize certain pathological changes, such as the increase in renal plasma flow and the failure of the urine concentration ability. On the basis of renal biopsies, two pathogenetic theories are discussed: the functional impairment of the countercurrent system and fibrosis of the medullary tissue.

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Section: Discussionmentioning

confidence: 99%

Function of the Kidney in Adult Patients with Cooley’s Disease

Mastrangelo¹,

Lopez²,

Rizzelli³

et al. 1975

Nephron

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“…Examination of the kidneys from patients with multiple myeloma has failed to demonstrate characteristic changes in the glomeruli that can account for the frequent occurrence of renal insufficiency associated with this illness (Boulet, Mirouze, Pages, Barjon, Fabre, and Jaffiol, 1962;Hamburger, Richet, Crosnier, and Antoine, 1966;Kenis et al, 1966;Reubi, 1970;. The repeatedly described thickenings of the basement membrane, the increases in the numbers of epithelial, endothelial, and mesangial cells, as well as subepithelial deposits (Abrahams, Pirani, and Pollak, 1966;Costanza and Smoller, 1963;Fries, Bansilion, Brunat, Molinie, and Traeger, 1967;Kobemick and Whiteside, 1957;Rosen, Cortell, Adner, Papadopoulos, and Barry, 1967), are, according to Fisher, Perez-Stable, and Zawadzki (1964), more likely to be the result of an altered protein supply than the cause of renal disturbances.…”

Section: Discussionmentioning

confidence: 99%

Glomerular nodules and long-spacing collagen in kidneys of patients with multiple myeloma

Schubert

Adam

1974

J Clin Pathol

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Light microscopic examination of the kidneys in 170 patients with multiple myeloma revealed three from patients without diabetes with glomerular nodules that were indistinguishable from those of diabetic glomerular sclerosis. Electron microscopic studies showed the nodules to be deposits of fine-grained material that corresponded to precipitations of protein but lacked the basement-membrane-like material characteristic of nodular glomerulosclerosis in diabetics. What is more, a unique collagen was observed in the marginal area of the nodules and in the periglomerular interstitium. The possible causes of the origin and distribution of this collagen not so far described in the human kidney are discussed.

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“…Im Vergleich mit mbuluszellspezifischen Parametern wie Beta-2-Mikroglobulin und N-acetyl-glucosaminidase (NAG) erweist sich jedoch Kreatinin als unempfindlich [8,12]. Aus Untersuchungen von Reubi [22] Bei Kenntnis der pathophysiologischen Grundlagen fiberrascht das nicht.…”

Section: Methodenunclassified

Die 131-Jod-Hippuranclearance zur Erfassung der nephrotoxischen Wirkung von cis-Dichlorodiamino-Platin (II) (cis-Platin, cis-DDP)

Hartenstein

Büll

et al. 1983

Klin Wochenschr

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In 25 patients, who received repeated doses of cis-DDP, we determined iodo-131-hippurate-clearance, creatinine clearance and serum creatinine to assess the nephrotoxic effect induced by cis-DDP. A highly significant decrease in the iodo-131-hippurate-clearance was found between the first and the following cycles. There was no significant change in serum creatinine and creatinine clearance however. The radio-hippurate-clearance showed a clinically not important reduction during several cytotoxic courses in 15/25 patients (60%). A clinically relevant impairment of the radio-hippurate-clearance occurred in 8/25 patients (32%), mainly before the third and fifth cytotoxic cycle. In two patients this clearance did not alter or was even rising. In 12 cases a diminuation of the iodo-131-hippurate-clearance was observed, which in only 5 cases correlated to a decreased creatinine clearance and in only two cases to an elevated serum creatinine. Therefore, we consider neither creatinine nor creatinine clearance nor the combination of both parameters to be appropriate to assess tubular nephropathy induced by cis-DDP. Radio-hippurate-clearance should play a superior role deciding on treatment stop or dose reduction of cis-DDP. The regression of cis-DDP-induced nephropathy was not evaluated.

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Klinik und Therapie der Glomerulonephritiden

Cited by 4 publications

References 191 publications

Function of the Kidney in Adult Patients with Cooley’s Disease

Function of the Kidney in Adult Patients with Cooley’s Disease

Glomerular nodules and long-spacing collagen in kidneys of patients with multiple myeloma

Die 131-Jod-Hippuranclearance zur Erfassung der nephrotoxischen Wirkung von cis-Dichlorodiamino-Platin (II) (cis-Platin, cis-DDP)

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