Klinische Symptomatik, differenzialdiagnostische Schwierigkeiten und Therapieoptionen bei tumorartigen Läsionen der Orbita

Abstract

Tumour-like lesions are very rare entity among orbital diseases. Between 1996 and 2007, 83 patients with orbital disorders were treated and three of them complained about different tumour-like lesions: giant cell granuloma, eosinophilic granuloma and fibrous dysplasia. Because of the considerable increase of functional disorders and tumour growth, all of the patients underwent surgical treatment. In this paper we describe the clinical symptoms, diagnostics and the methods of therapy for each of the lesions. The results shows that the preoperative neuro-ophthalmological examination as well as radiological imaging are necessary to assess the motility, visual field, vision, eye ball dislocation and to plan the surgical strategy. In terms of this descriptive character of the paper, we hope to submit some relevant information in order to improve the diagnostics and therapeutic procedures for tumour-like lesions of the orbit.

Langerhans Cell Histiocytosis of the Orbit: Five Clinicopathologic Cases and Review of the Literature

“…The histologic differential diagnosis of LCH include giant cell reparative granuloma, 63 hemorrhagic cyst, cholesterol granuloma (cholesteatoma), 64 Erdheim-Chester disease, 65 giant cell aneurysma of bone, giant cell tumor, and histiocytic sarcoma. These entities exhibit histologic features, are composed of CD1a- macrophages (not CD1a+ Langerhans cells) and can be excluded from LCH by immunohistochemical staining.…”