Klinische und tierexperimentelle Untersuchungen zur Nierenfunktion unter Angiotensin und Mannit

Bihler, K; Jahnecke, J; Sökeland, Jürgen

doi:10.1007/978-3-642-46150-7_4

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“…An identical mannitol dose administered over a 5 1/2 minute period at nearly twice the infusion rate produces a rise in the perfusion curve by 15 70, with a 670 lower level being attained after 5 more minutes. From our results, which are in good agreement with those of Schneeberg [8] and Bihler [1], it may thus be concluded that intravenous administration of angiotensin II in acute hypotensive disorders is warranted if mannitol is infused concurrently and if previous volume replacement had not shown any improvement. 20 mm Hg -is conspicuous (Fig.…”

Section: Resultssupporting

confidence: 90%

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Influence of angiotensin II and mannitol on local renal blood flow

Bihler

Sökeland

et al. 1969

Urology and Nephrology

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The present report outlines investigations in experimental animals (dogs) conducted for the purpose of studying the effect of angiotensin II and 10 ~ mannitol solution on local renal blood flow. Most of the experiments were carried out in normovolaemic conditions, a few of them in haemorrhagic shock. Following the description of the experimental set-up and the procedure employed, the response of the arterial blood pressure and the local renal blood flow to mannitol infusion in normovolaemia is delineated with the help of a tabular summary. Experiments in haemorrhagic shock seem to suggest that concurrent intravenous administration of mannitol and angiotensin II in acute hypotensive circulation is warranted if preceding volume replacements have not yielded an adequate stabilizing effect on the circulation.Clearance studies on experimental animals have revealed that the angiotensin-induced depressor effect on renal function is prevented by simultaneous mannitol administration. Human clearance experiments have shown that on the other hand renal function following sole administration of angiotensin II is compensated in part by co-administering mannitol.The observation that clearance studies, due to their low resolving power, are apt to illuminate only relatively protracted functions prompted us to investigate the acute changes in local renal blood flow and blood pressure after administration of angiotensin II and mannitol using a suitable Hensel probe. MethodExperiments were conducted on 17 fasted mongrel dogs of both sexes in the supine position. Their weight varied from 15 to 38 kg.

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Section: Resultssupporting

confidence: 90%

“…The following original curvef wilI serve to demonstrate the typical reactions to best advantage. Urology and Nephrology 1,1969 In one dog with haemorrhagic shock and a mean arterial pressure of approx. The arterial blood flow and the central venous pressure remained unchanged (Fig.…”

Section: Resultsmentioning

confidence: 99%