2024
DOI: 10.3390/genes15111444
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Klrb1 Loss Promotes Chronic Hepatic Inflammation and Metabolic Dysregulation

Shuqi Yang,
Tingting Luo,
Haoran Liu
et al.

Abstract: Background/Objectives: CD161, encoded by the KLRB1 gene, is an inhibitory receptor expresses on various immune cell and has gained attention in immune checkpoint research. In recent studies, KLRB1 has been found to be one of the potential markers of liver diseases such as cirrhosis. Therefore, it will be important to understand what process KLRB1 involved in the liver for the prevention of liver diseases. Methods: We compared KO mice with wild-type controls by routine blood analysis and RNA-seq, and additional… Show more

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