“…Exercise with or without manipulative and soft tissue therapy or, combined with other modalities such as orthotics, knee braces, and tape, demonstrates comparable short-term usefulness. [1][2][3][4][5][10][11][12][13][14][15][16][17][18] In clinical trials, manipulative therapy (defined as all grades of mobilization I-IV including manipulation or grade V high-velocity low-amplitude thrust) for PFPS has been restricted to patellofemoral joint mobilization with manipulation of lumbopelvic joints occasionally added. [1][2][3][4][5]8,[19][20][21] A few trials, designed to treat knee osteoarthritis, have also used full kinetic chain (FKC) manipulative therapy for joint dysfunction in the lumbosacral, hip, knee, ankle, and foot.…”