Knee cartilage defects: association with early radiographic osteoarthritis, decreased cartilage volume, increased joint surface area and type II collagen breakdown

Ding, Changhai; Garnero, Patrick; Cicuttini, Flavia Maria; Scott, F; Cooley, Helen M; Jones, Graeme

doi:10.1016/j.joca.2004.11.007

Cited by 288 publications

(336 citation statements)

References 27 publications

Supporting

Mentioning

313

Contrasting

Unclassified

Order By: Relevance

“…MR sequences used for semiquantitative scoring of cartilage lesions involve T 1 -weighted spoiled gradient recalled acquisition at steady state (SPGR ¼ spoiled gradient echo or FLASH ¼ fast low-angle shot) with fat suppression (38,(40)(41)(42)(43)(44)(45)(46)(47) the internal structure of the cartilage displays a more heterogeneous signal and 'internal' pathological changes may be more readily displayed. Also, cartilage surface lesions are well depicted with these sequences, because of the steep gradient of signal intensity between the cartilage and the synovial fluid, in particular when effusion is present [ Fig.…”

Section: Semiquantitative Scoring Of Articular Tissues In Oa Hardwarementioning

confidence: 99%

“…MR sequences used for semiquantitative scoring of cartilage lesions involve T 1 -weighted spoiled gradient recalled acquisition at steady state (SPGR ¼ spoiled gradient echo or FLASH ¼ fast low-angle shot) with fat suppression (38,(40)(41)(42)(43)(44)(45)(46)(47) or selective water excitation (we) (48) [Figs 1, 2 and 3(a)], fat-suppressed T 2 -or intermediate (IM) weighted fast spin-echo (FSE) (38,43,(49)(50)(51)(52) [ Fig. 3(b) and (c)] and fat-suppressed driven equilibrium Fourier transform (DEFT) imaging (53).…”

Section: Semiquantitative Scoring Of Articular Tissues In Oa Hardwarementioning

confidence: 99%

“…Peterfy et al (43) reported cartilage changes and osteophytes to be the most prominent features (>90%) in 19 patients with knee OA [Kellgren Lawrence grade (KLG) 2 and 3] whereas meniscal injury (80%) bone cysts (77%), synovitis (75%), marrow abnormalities (57%), bone attrition (48%) and ligament injuries (8%) were less frequent. In a sample of 372 male and female subjects, aged 26-61 years, knee cartilage defect severity (sagittal fat-suppressed SPGR) was shown to be associated with age and radiographic OA status (45), body mass index (BMI) (46) and C-terminal crosslinking telopeptide of type II collagen (44).…”

Section: Technical Accuracy and Precision Of Measurementsmentioning

confidence: 99%

See 2 more Smart Citations

Quantitative MRI of cartilage and bone: degenerative changes in osteoarthritis

2006

View full text Add to dashboard Cite

Magnetic resonance imaging (MRI) and quantitative image analysis technology has recently started to generate a great wealth of quantitative information on articular cartilage and bone physiology, pathophysiology and degenerative changes in osteoarthritis. This paper reviews semiquantitative scoring of changes of articular tissues (e.g. WORMS ¼ whole-organ MRI scoring or KOSS ¼ knee osteoarthritis scoring system), quantification of cartilage morphology (e.g. volume and thickness), quantitative measurements of cartilage composition (e.g. T 2 , T 1rho , T 1Gd ¼ dGEMRIC index) and quantitative measurement of bone structure (e.g. app. BV/TV, app. TbTh, app. Tb.N, app. Tb.Sp) in osteoarthritis. For each of these fields we describe the hardware and MRI sequences available, the image analysis systems and techniques used to derive semiquantitative and quantitative parameters, the technical accuracy and precision of the measurements reported to date and current results from cross-sectional and longitudinal studies in osteoarthritis. Moreover, the paper summarizes studies that have compared MRI-based measurements with radiography and discusses future perspectives of quantitative MRI in osteoarthritis. In summary, the above methodologies show great promise for elucidating the pathophysiology of various tissues and identifying risk factors of osteoarthritis, for developing structure modifying drugs (DMOADs) and for combating osteoarthritis with new and better therapy. Copyright # 2006 John Wiley & Sons, Ltd.KEYWORDS: osteoarthritis; joint; cartilage; bone; magnetic resonance imaging; knee; image analysis; disease-modifying drugs RATIONALE FOR QUANTITATIVE MRI OF CARTILAGE AND BONE IN OSTEOARTHRITISThe health and integrity of diarthrodial (synovial) joints are prerequisites for pain-free movement and have a major impact on the quality of life. However, the population of individuals above the age of 65 years is rapidly growing and 70% of the women and 60% of the men aged 65 years or older suffer from degenerative joint disease [¼ osteoarthritis (OA)] (1-7). OA has been defined by the American College of Rheumatology (ACR) as a 'heterogeneous group of conditions that leads to joint symptoms and signs which are associated with defective integrity of articular cartilage, in addition to related changes in the underlying bone at the joint margins'. It remains an open question whether the initial changes take place in cartilage or bone or other articular tissues and, more importantly, what the causal relationship between these changes is (5-19). Also, within each NMR IN BIOMEDICINE NMR Biomed. 2006; 19: 822-854 Published online in Wiley InterScience (www.interscience.wiley.com). DOI:10.1002/nbm.1063 narrowing; JSW, joint space width; K, knee; KLG, Kellgren Lawrence grade; KOSS, knee osteoarthritis scoring system; LF, lateral femoral condyle; LT, lateral tibia; MRI, magnetic resonance imaging; MF, medial femoral condyle; MT, medial tibia; OA, osteoarthritis; OAI, Osteoarthritis Initiative; P, patella; PGs, proteoglycans;...

show abstract

Section: Semiquantitative Scoring Of Articular Tissues In Oa Hardwarementioning

confidence: 99%

“…MR sequences used for semiquantitative scoring of cartilage lesions involve T 1 -weighted spoiled gradient recalled acquisition at steady state (SPGR ¼ spoiled gradient echo or FLASH ¼ fast low-angle shot) with fat suppression (38,(40)(41)(42)(43)(44)(45)(46)(47) or selective water excitation (we) (48) [Figs 1, 2 and 3(a)], fat-suppressed T 2 -or intermediate (IM) weighted fast spin-echo (FSE) (38,43,(49)(50)(51)(52) [ Fig. 3(b) and (c)] and fat-suppressed driven equilibrium Fourier transform (DEFT) imaging (53).…”

Section: Semiquantitative Scoring Of Articular Tissues In Oa Hardwarementioning

confidence: 99%

Section: Technical Accuracy and Precision Of Measurementsmentioning

confidence: 99%

See 1 more Smart Citation

Quantitative MRI of cartilage and bone: degenerative changes in osteoarthritis

2006

View full text Add to dashboard Cite

show abstract

“…Cartilage defects (see Figure 2) were graded in tibiofemoral and patellofemoral compartments using a classification system previously described where grade 0 represents normal cartilage and grade 4 full-thickness cartilage wear with exposure of subchondral bone [14]. A prevalent cartilage defect was defined as a cartilage defect score of > 2 at any site.…”

Section: Mri Assessment Of Knee Structurementioning

confidence: 99%

“…A prevalent cartilage defect was defined as a cartilage defect score of > 2 at any site. Intra-and inter-observer reliability (expressed as intra-class correlation coefficient) were 0.89 to 0.94, and 0.85 to 0.93, respectively [14]. Tibial and patellar cartilage volumes were measured to the nearest 1 mm 3 using the software ImageJ (National Institutes of Health, USA) and Osiris (University Hospitals of Geneva, Switzerland), respectively [43].…”

Section: Mri Assessment Of Knee Structurementioning

confidence: 99%

Patellofemoral and tibiofemoral articular cartilage and subchondral bone health following arthroscopic partial medial meniscectomy

Wang

Dempsey

Lloyd

et al. 2011

Knee Surg Sports Traumatol Arthrosc

View full text Add to dashboard Cite

Methods: For this cross-sectional study, 158 patients aged 30-55 years, without evidence of knee osteoarthritis at arthroscopic partial medial meniscectomy (APMM), and 38 controls were recruited. MRI was performed once on the operated knee for each subcohort of 3 months, 2 years, or 4 years post-surgery, and the randomly assigned knee of the controls. Cartilage volume, cartilage defects, and bone size were assessed using validated methods. Conclusions: Partial medial meniscectomy is associated with adverse effects on articular cartilage and subchondral bone, which are associated with subsequent osteoarthritis, in both tibiofemoral and patellofemoral compartments. Level of Evidence: Level III

show abstract

Natural History of Knee Cartilage Defects and Factors Affecting Change

Ding¹,

Cicuttini²,

Scott³

et al. 2006

Arch Intern Med

Self Cite

152

162

View full text Add to dashboard Cite

Background: Knee cartilage defects may play an important role in early osteoarthritis, but little is known about their natural history.Methods: Knee cartilage defect score (range, 0-4), cartilage volume, and bone surface area were determined using T1-weighted fat-saturated magnetic resonance imaging in 325 subjects (mean age, 45 years) at baseline and 2 years later.Results: Thirty-three percent of the subjects had a worsening (Ն1-point increase) and 37% of the subjects had an improvement (Ն1-point decrease) in cartilage defect score in any knee compartment during 2.3 years. A worsening in cartilage defect score was significantly associated with female sex (odds ratio [OR], 3.09 and 3.64 in the medial and lateral tibiofemoral compartments) and baseline factors, including age (OR, 1.05 per year in the medial tibiofemoral compartment), body mass index (OR, 1.08 in the lateral tibiofemoral compartment), tibiofemoral osteophytes (OR, 6.22 and 6.04 per grade), tibial bone area (OR, 1.24 and 2.07 per square centimeter), and cartilage volume (OR, 2.91 and 1.71 per milliliter in the medial tibiofemoral and patellar compartments). An improvement in cartilage defect score had similar but reversed associations with these factors (except for sex), including a decrease in body mass index (OR, 1.23 in the medial tibiofemoral compartment).Conclusions: Knee cartilage defects are variable, and changes are associated with female sex, age, and body mass index. Increases are associated with baseline cartilage volume, bone size, and osteophytes, suggesting a role for these in the pathogenesis of cartilage defects. Interventions such as weight loss may improve knee cartilage defects.

show abstract

Knee cartilage defects: association with early radiographic osteoarthritis, decreased cartilage volume, increased joint surface area and type II collagen breakdown

Cited by 288 publications

References 27 publications

Quantitative MRI of cartilage and bone: degenerative changes in osteoarthritis

Quantitative MRI of cartilage and bone: degenerative changes in osteoarthritis

Patellofemoral and tibiofemoral articular cartilage and subchondral bone health following arthroscopic partial medial meniscectomy

Natural History of Knee Cartilage Defects and Factors Affecting Change

Contact Info

Product

Resources

About