Knee osteoarthritis. Efficacy of a new method of contrast-enhanced musculoskeletal ultrasonography in detection of synovitis in patients with knee osteoarthritis in comparison with magnetic resonance imaging

Song, I.-H.; Althoff, Christian E.; Hermann, Kay-Geert A.; Scheel, Alexander; Knetsch, T; Schoenharting, M; Werner, Carola; Burmester, Gerd-RÃ1⁄4diger; Backhaus, Marina

doi:10.1136/ard.2006.067462

Cited by 95 publications

(49 citation statements)

References 36 publications

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“…Using contrastenhanced ultrasound increased this detection rate to 95% (on assessment of the superior recess). Unlike Hill and colleagues' MRI work, this study did not find an association between VAS pain and degree of synovitis, although the numbers in the study were small [Song et al 2008].…”

Section: Ultrasoundcontrasting

confidence: 53%

The role of synovitis in osteoarthritis

Wenham

Conaghan

2010

Therapeutic Advances in Musculoskeletal

139

109

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Osteoarthritis (OA) is the most common form of arthritis worldwide yet there is still a lack of effective treatments for this condition. Increasingly, attention has turned to the role of the synovium in OA as it is now recognized, in part from the use of modern imaging techniques, that synovitis is both common and associated with pain. This offers a target for treatment, for both symptom and potential structure modification. In this review we discuss the evidence for histological and imaging-detected synovitis and the current role of antisynovial therapies in OA.

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Section: Ultrasoundcontrasting

confidence: 53%

The role of synovitis in osteoarthritis

Wenham

Conaghan

2010

Therapeutic Advances in Musculoskeletal

139

109

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“…This limit, which represents the upper quartile in the findings for healthy controls, has biological face validity, but could be too strict, as PD can be detected in healthy controls [38] and OA patients [39,40]. The origin of the signal can be investigated using colour Doppler US and the spectral Doppler Resistivity Index, which can differentiate between inflammatory and non-inflammatory disease and can be used as an indicator of RA inflammation [41].…”

Section: Discussionmentioning

confidence: 99%

Superiority of SDAI over DAS-28 in assessment of remission in rheumatoid arthritis patients using power Doppler ultrasonography as a gold standard

et al. 2010

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Objective. To investigate the accuracy of composite scores in classifying RA patients who are in remission using the absence of inflammatory activity detected by ultrasound (US) as a gold standard.Methods. Ninety-seven RA patients who were classified by their rheumatologists as being in remission were studied. Disease activity was assessed by the DAS-28 and simplified disease activity index (SDAI). US examination was performed in mode B and power Doppler (PD) in 42 joints.Results. Synovial hypertrophy (SH) and PD were present in 92 (94.8%) and 41 (42.3%) patients. If we consider 'remission' to be the absence of joints with PD signal, no differences were found by DAS-28 between patients in remission and those not in remission, although differences were present by SDAI. We then calculated the sensitivity (S), specificity (Sp) and positive likelihood ratio (LR) of different SDAI cut-off points to predict absence of PD signal. SDAI < 5 had an S of 65% (95% CI 52, 76), Sp of 55% (95% CI 39, 69) and LR of 1.45 (95% CI 0.98, 2.15), whereas SDAI < 3.3 had an S of 57% (95% CI 44, 69), Sp of 74% (95% CI 58, 85) and LR of 2.24 (95% CI 1.25, 4.01). Conclusions.Our results suggest that the SDAI classification of remission is closer to the concept of an absence of inflammatory activity, as defined by the absence of positive PD signal by US.

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“…Therefore, contrast-enhanced ultrasound in knee OA with the use of specific intravenously injected microbubbles can be used and has been shown to improve the detection of vascularity in joints of patients with OA when compared with PDUS. Moreover, contrast-enhanced ultrasound has even been reported to have a higher sensitivity in the detection of vascularity in comparison to contrast-enhanced MRI in patients with knee OA [29]. …”

Section: Radiological Measurement Of Knee Oamentioning

confidence: 99%

Clinical Imaging Assessments of Knee Osteoarthritis in the Elderly: A Mini-Review

Wick¹,

Kastlunger

Weiss

2014

Gerontology

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Knee osteoarthritis (OA) in the elderly is one of the most common degenerative age-related joint diseases leading to typical degradation of articular cartilage with severe pain and limitation of joint motion. Its increasing prevalence due to the demographic development of the society has major implications for individual and public healthcare with the increasing necessity for clinical imaging assessment in a high number of individuals. Although conventional X-ray radiographs are widely considered as gold standard for the assessment of knee OA, in clinical and scientific settings they increasingly bare significant limitations in situations when high resolution and detailed assessment of cartilage is demanded. New imaging modalities are broadening the possibilities in knee OA clinical practice and are offering new insights to help for a better understanding of the disease. X-ray analysis in OA of the knee is associated with many technical limitations and increasingly is replaced by high-quality assessment using magnetic resonance imaging or ultrasonography both in clinical routine and scientific situations. These novel imaging modalities enable an in vivo visualization of the quality of the cartilaginous structure and bone as well as all articular and periarticular tissues. Therefore, the limitations of radiographs in knee OA assessment could be overcome by these techniques. This review article should provide an insight into the most important radiological features of knee OA and their systematic visualization with different imaging approaches that can be used in clinical routine.

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Knee osteoarthritis. Efficacy of a new method of contrast-enhanced musculoskeletal ultrasonography in detection of synovitis in patients with knee osteoarthritis in comparison with magnetic resonance imaging

Cited by 95 publications

References 36 publications

The role of synovitis in osteoarthritis

The role of synovitis in osteoarthritis

Superiority of SDAI over DAS-28 in assessment of remission in rheumatoid arthritis patients using power Doppler ultrasonography as a gold standard

Clinical Imaging Assessments of Knee Osteoarthritis in the Elderly: A Mini-Review

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