Knee osteoarthritis in midlife women: unique considerations and comprehensive management

Curry, Zachary A; Beling, Alexandra; Borg‐Stein, Joanne

doi:10.1097/gme.0000000000001966

Cited by 13 publications

(7 citation statements)

References 75 publications

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“…Features of osteoarthritis that may be especially important to possibly mitigate are those of joint inflammation, excess weight gain or loss, muscle and bone attrition, nerve damage and impairments of those sensory mechanisms designed to foster joint protection and avert injury, common in vulnerable older adult osteoarthritis populations [23][24][25][26][27][28][29][30][31][32]. As put forth by Hunter et al [33], the appropriate selection and use of evidence-based management options is critical in this regard, but for helping the osteoarthritis client to obtain the full benefits from their treatment recommendations, they have to understand what is needed, and be able to act on these imperatives.…”

Section: Resultsmentioning

confidence: 99%

Osteoarthritis Literacy and Equity Issues: A Post COVID-19 Analysis and Update

Marks

2022

JARH

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Background Osteoarthritis, the most common joint disease and one affecting a large number of older adults is not always amenable to the use of passive interventions such as surgery or pharmacologic interventions, but even then, to maximize any desirable intervention approaches, a trustworthy and supportive partnership with the sufferer is strongly indicated. Complicating this process are emerging equity and persistent health literacy issues, as well as post COVID-19 service associated ramifications and persistent disease risks. Aim This mini review was designed to examine what current data reveal as regards the presentation of osteoarthritis and its pathology among the older adult as of the current post COVID-19 pandemic period in 2022, and how health literacy and equity issues are likely implicated in some degree with the disease presentation and its outcomes and will be likely to continue, unless remediated. Methods Peer reviewed published articles on this topic were sought from multiple data bases using the key words- osteoarthritis, health equity, health literacy, prevention, and intervention. Results As in prior years, osteoarthritis continues to induce considerable physical disability and consistently impedes the attainment of a high life quality for many older adults. Although not studied to any degree, attention to health equity and literacy issues appear to pose additional osteoarthritis intervention challenges, especially among the long COVID affected older adults and those with low income and educational levels. Conclusions Many behaviourally oriented and necessary osteoarthritis management approaches and interventions may fail to reduce the functional disability and pain experienced by older people with any form of osteoarthritis to any meaningful degree if a) the provider does not tailor their recommendations in light of possible prevailing health literacy, economic, and educational challenges; b) the patient does not understand how their health behaviours impact joint disease as well as COVID-19 risk status, and are not empowered to undertake these.

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Section: Resultsmentioning

confidence: 99%

Osteoarthritis Literacy and Equity Issues: A Post COVID-19 Analysis and Update

Marks

2022

JARH

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“…A higher prevalence rate of knee osteoarthritis among post-menopause women compared to men of similar age may explain a higher problem reporting rate in mobility, usual activity, and pain/discomfort. Women are known to have a greater risk of osteoarthritis development, and menopause has a multitude of effects on hormones, bone minerals, muscles, and tendons that, in turn, affect knee osteoarthritis ( 25 , 26 ). Pregnancy may also contribute to the poorer HRQoL of women.…”

Section: Discussionmentioning

confidence: 99%

Health-related quality of life of Korean older adults according to age, sex, and living arrangements: a cross-sectional study

Hwang,

Jeong,

Yim

2023

Front. Public Health

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IntroductionThe number and proportion of older adults living alone is a significant issue. While the number of the oldest old people is also expected to increase, their health characteristics are poorly understood. This study aims to evaluate the health-related quality of life (HRQoL) of the oldest old people according to age, sex, and living arrangements.MethodsThis study is based on the Korea Community Health Survey 2021. Among the survey's 229,242 observations, 73,617 observations aged 65 or higher were used for the analysis. The study participants were divided into 5-year age intervals (from 65–69 to 90+), sex, and living arrangements. The outcome variables are the EuroQol 5 Dimensions (EQ-5D) index score and the problem reporting rates of the five dimensions of EQ-5D.ResultsThe mean EQ-5D index scores were 0.896 at 65–69 and 0.741 at 90+. The mean EQ-5D index score decreased more rapidly as age increased. Women showed consistently lower mean EQ-5D index scores than men in all age intervals. The proportion of older adults living alone increased from 18.1% at 65–69 to 43.6% at 90+. The odds of reporting problems with anxiety/depression among older men living alone were estimated to be significantly higher than older men living with someone (aOR 1.22 95% CI 1.05–1.43). The odds of reporting problems in self-care and usual activity among older women living alone were estimated to be significantly lower than older women living with someone (aOR 0.88 95% CI 0.70–0.83 and aOR 0.88 95% CI 0.82–0.94)ConclusionThis study showed that older adults' HRQoL deteriorates as their age increases. Moreover, living alone may lead to different effects on older adults' HRQoL according to sex. More comprehensive studies and collaborative attention are needed to identify and provide customized care for older adults.

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“…In addition, the chance of suffering from OA can be influenced by age and the obesity epidemic. Obesity is a risk factor since the extra strain on the joints over time may result in unnecessary tension and damage [13,14]. Furthermore, metabolic obesity-related factors can contribute to the progression of joint diseases.…”

Section: Osteoarthritis 21 Osteoarthritis Epidemiology In Humanmentioning

confidence: 99%

The Importance of Neutrophils in Osteoarthritis: Current Concepts and Therapeutic Perspectives

Mehrani

Junqani

Morovati

et al. 2023

Immuno

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Osteoarthritis (OA) is the most common degenerative joint disease that causes chronic pain and disability. Different innate immune components, including macrophages, T cells, and neutrophils, participate in OA pathophysiology. Neutrophils are the most abundant circulating leukocytes with multiple specialized functions contributing to innate and adaptive immune functions. Although neutrophils produce proinflammatory cytokines and chemokines, reactive oxygen species (ROS), matrix-degrading enzymes, and neutrophil extracellular traps (NET) that promote joint degradation as the first recruit cells in an inflamed joint, these cells also play an important role in joint repair by regulating the immune response, releasing anti-inflammatory factors, and activating certain protective genes. In this review, various aspects of neutrophil biology, their role in inflammation and its association with OA, and possible therapeutic approaches to target neutrophils for the treatment of OA are described. Since neutrophils play a complex role in the pathophysiology of osteoarthritis, contributing to joint degradation as well as joint repair, targeting these cells is likely to pave the way for a potential therapeutic approach for the management of OA. Future studies are needed to investigate the use of targeted therapies to modulate neutrophil function and identify their subpopulations that are associated with osteoarthritis progression or response to treatment.

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Knee osteoarthritis in midlife women: unique considerations and comprehensive management

Cited by 13 publications

References 75 publications

Osteoarthritis Literacy and Equity Issues: A Post COVID-19 Analysis and Update

Osteoarthritis Literacy and Equity Issues: A Post COVID-19 Analysis and Update

Health-related quality of life of Korean older adults according to age, sex, and living arrangements: a cross-sectional study

The Importance of Neutrophils in Osteoarthritis: Current Concepts and Therapeutic Perspectives

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