Knee osteochondritis dissecans-treatment technical aspects

Brittberg, Mats

doi:10.1016/j.jor.2022.08.005

Cited by 6 publications

(1 citation statement)

References 60 publications

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“…Up to 10% of adolescents and young adults with knee hemarthrosis following acute trauma present a focal chondral damage [ 2 ]. Osteochondritis dissecans (OCD) is an idiopathic necrosis in a localized weight-bearing area of epiphyseal cartilage or subchondral bone and is the most common non-traumatic cause of focal chondral defect in skeletally immature patients [ 9 , 18 , 28 , 58 ].…”

Section: Introductionmentioning

confidence: 99%

Autologous chondrocyte implantation in the knee is effective in skeletally immature patients: a systematic review

Migliorini

Eschweiler

Prinz

et al. 2022

Knee Surg Sports Traumatol Arthrosc

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Purpose This systematic review evaluated the efficacy and safety of autologous chondrocyte implantation (ACI) for chondral defects of the knee in skeletally immature patients. Current available data from patients reported outcome measures (PROMs) and complications were collected, analyzed, and discussed. Methods This systematic review was conducted according to the PRISMA guidelines. The following databases were accessed in May 2022: PubMed, Google scholar, Embase, and Scopus. All the clinical studies investigating the efficacy of ACI to manage chondral defects of the knee in skeletally immature patients were accessed. Articles treating patients with surgical procedures other than ACI were not eligible, nor were studies with a follow-up shorter than 12 months. Results Data from 9 studies (251 procedures) were collected. 32% (80 of 251) of patients were females. The mean length of follow-up was 44.2 ± 29.4 (range, 12–115) months. The mean age of the patients was 16.4 ± 0.7 (range, 15–17) years. The Knee injury and Osteoarthritis Outcome Score (KOOS) and International Knee Document Committee (IKDC) increased of + 41.9/100 (P = 0.003) and + 33.2/100 (P = < 0.0001) points, respectively. The Lysholm Knee Score improved of + 20.6/100 (P = 0.02) points. The Visual Analogue Scale (VAS) for pain reduced of − 3.6/10 (P = 0.004) points. The Tegner scale did not show any statistically significant improvement from baseline to follow-up (P = n.s.). The rate of graft hypertrophy was 12.5% (5 of 40 patients), and the rate of failure 5.6% (8 of 142 patients). Conclusion ACI for chondral defects of the knee is effective to improve PROMs in skeletally immature patients. The safety profile of ACI still remains controversial. Level of evidence III.

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