Knee-related disability was largely influenced by cognitive factors and disturbed body perception in knee osteoarthritis

Nishigami, Tomohiko; Tanaka, So; Mibu, Akira; Imai, Ryota; Wand, Benedict M

doi:10.1038/s41598-021-85307-1

Cited by 16 publications

(10 citation statements)

References 45 publications

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“…Many of these studies considered various combination of clinical characteristics only including but not limited to BMI, radiographic scores, pain metrics, bone mineral density, magnetic resonance imaging (MRI) score, Hb-A1C, cholesterol, depression symptoms, serum, and urine biomarkers. 8 , 9 , 27 - 29 Similar to our findings, some of these studies also found KL radiographic score and BMI as characteristics that can be used to discriminate OA subgroups. 8 , 27 , 28 Few other studies focused on the RNA sequencing and metabolic profiling of cartilage and SYN to identify OA subgroups.…”

Section: Discussionsupporting

confidence: 90%

“… 8 , 9 , 27 - 29 Similar to our findings, some of these studies also found KL radiographic score and BMI as characteristics that can be used to discriminate OA subgroups. 8 , 27 , 28 Few other studies focused on the RNA sequencing and metabolic profiling of cartilage and SYN to identify OA subgroups. 6 , 7 , 10 , 11 , 30 These studies have reported cartilage extracellular matrix genes (GAG) and collagen-associated genes to discriminate OA subgroups.…”

Section: Discussionsupporting

confidence: 90%

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Assessment of Clinical, Tissue, and Cell-Level Metrics Identify Four Biologically Distinct Knee Osteoarthritis Patient Phenotypes

et al. 2022

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Objective Clinical heterogeneity of primary osteoarthritis (OA) is a major challenge in understanding pathogenesis and development of targeted therapeutic strategies. This study aims to (1) identify OA patient subgroups phenotypes and (2) determine predictors of OA severity and cartilage-derived stem/progenitor concentration using clinical-, tissue-, and cell- level metrics. Design Cartilage, synovium (SYN) and infrapatellar fatpad (IPFP) were collected from 90 total knee arthroplasty patients. Clinical metrics (patient demographics, radiograph-based joint space width (JSW), Kellgren and Lawrence score (KL)), tissue metrics (cartilage histopathology grade, glycosaminoglycans (GAGs)) and cell-based metrics (cartilage-, SYN-, and IPFP-derived cell concentration ([Cell], cells/mg), connective tissue progenitor (CTP) prevalence (PCTP, CTPs/million cells plated), CTP concentration, [CTP], CTPs/mg)) were assessed using k-mean clustering and linear regression model. Results Four patient subgroups were identified. Clusters 1 and 2 comprised of younger, high body mass index (BMI) patients with healthier cartilage, where Cluster 1 had high CTP in cartilage, SYN, and IPFP, and Cluster 2 had low [CTP] in cartilage, SYN, and IPFP. Clusters 3 and 4 comprised of older, low BMI patients with diseased cartilage where Cluster 3 had low [CTP] in SYN, IPFP but high [CTP] in cartilage, and Cluster 4 had high [CTP] in SYN, IPFP but low [CTP] in cartilage. Age ( r = 0.23, P = 0.026), JSW ( r = 0.28, P = 0.007), KL ( r = 0.26, P = 0.012), GAG/mg cartilage tissue ( r = −0.31, P = 0.007), and SYN-derived [Cell] ( r = 0.25, P = 0.049) were weak but significant predictors of OA severity. Cartilage-derived [Cell] ( r = 0.38, P < 0.001) and PCTP ( r = 0.9, P < 0.001) were moderate/strong predictors of cartilage-derived [CTP]. Conclusion Initial findings suggests the presence of OA patient subgroups that could define opportunities for more targeted patient-specific approaches to prevention and treatment.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 90%

Assessment of Clinical, Tissue, and Cell-Level Metrics Identify Four Biologically Distinct Knee Osteoarthritis Patient Phenotypes

et al. 2022

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“… 54 Furthermore, cluster analysis suggests that disrupted knee perception may explain some of the discrepancy between knee pain–related disability and severity of radiographic findings in knee OA. 37 Item 7 of the FreKAQ (back translated from Japanese: I feel like my knee is bigger [swollen]), specifically asks about knee size and the difference between perception and reality. We found that this item was significantly easier to endorse for people with knee OA than the similarly worded item was for people with low back pain, 35 neck pain, 63 or shoulder pain, 38 which suggests this issue might be particularly relevant in knee OA.…”

Section: Introductionmentioning

confidence: 99%

“But it feels swollen!”: the frequency and clinical characteristics of people with knee osteoarthritis who report subjective knee swelling in the absence of objective swelling

Tanaka

Nishigami

Ohishi³

et al. 2021

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Introduction: There are complex interactions between pain and perceptions of the painful body part in musculoskeletal disorders, and disruption of various body representations in people with chronic pain. Objectives: The purpose of this study was to investigate how frequently people with knee osteoarthritis (OA) complain of swelling without objective evidence of swelling, and describe the clinical characteristics of this population. Methods: Forty-six people with knee OA (68.1 6 8.8 years) participated in this cross-sectional study. Subjective and objective swelling was evaluated by knee-specific body perception questionnaire and ultrasonography, respectively. Pain intensity, disability, pain-related beliefs, 2-point discrimination threshold, and quadriceps muscle strength were also evaluated.Results: Approximately 1/3 of participants (n 5 15) had subjective feelings of knee swelling in the absence of objective swelling (S only). Fifteen participants had both subjective and objective knee swelling (S 1 O group) and 16 had neither subjective nor objective knee swelling (No S/O group). Participants in the S only group had similar pain or disability as those in the S 1 O group but had more severe pain or disability than those with in the No S/O group. Those in the S only group also had larger 2-point discrimination distance threshold at the medial knee (impaired tactile acuity) than those in the S 1 O group and had more dysfunctional pain catastrophizing and pain-related self-efficacy than both other groups. Conclusion: Our results suggest that about 30% of people with knee OA perceive swelling of the knee in the absence of any objective swelling and that this is accompanied by severe pain and functional disability. Considering altered body image of the knee may reveal relevant treatment-based subgroups in people with knee OA.

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“…Because of osteoarthritis, over 100,000 persons in the United States are unable to walk from their bedroom to their bathroom due to reduced muscle strength, disturbed body perception and joint dysfunction. 5,6,7 Imbalance between the muscles may arise when a person have tight hip joint musculature which ultimately leads to injury. Due to the hip flexors and quadriceps overworking to compensate for weak muscles it may frequently causes fatigue and reduction in strength eventually cause knee and hip pain.…”

Section: Introductionmentioning

confidence: 99%

To study the effects of knee osteoarthritis on hip flexibility among elders.

Sheraz

Sarwar

Saeed

et al. 2022

TPMJ

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Objectives: To determine the effect of knee osteoarthritis on hip flexibility by using Modified Thomas Test. Study Design: Observational study. Setting: Department of Physiotherapy and Orthopedic, Shalamar Hospital, Lahore. Period: 1 July 2021 to 31 December 2021. Material & Methods: This study recruited 40 participants of either sex, age between 30- 70 years. Results: The response of study was 100%. Frequency of females with osteoarthritis was 82.5 males was 17.5%. Among the patients 33 were females and 7 were males. T-Test was performed for parameters of age in years, height in inches, weights in kgs for females and males. The mean age was 51.79±9.303 years for female and 55.43±8.404 years for male. Weight in kgs for female was 76.03±9.133 and for male was 94.57±20.911. In T test the height in inches for female was 61.45±2.399 and for male was 65.57±3.735. The co-relation between hip flexibility and knee osteoarthritis was moderately significant and flexibility was reduced because of osteoarthritis. Conclusion: It was concluded that hip flexibility is reduced with osteoarthritis of knee joint and due to reduced mobility of hip joint routine daily activities of patient was hampered.

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Knee-related disability was largely influenced by cognitive factors and disturbed body perception in knee osteoarthritis

Cited by 16 publications

References 45 publications

Assessment of Clinical, Tissue, and Cell-Level Metrics Identify Four Biologically Distinct Knee Osteoarthritis Patient Phenotypes

Assessment of Clinical, Tissue, and Cell-Level Metrics Identify Four Biologically Distinct Knee Osteoarthritis Patient Phenotypes

“But it feels swollen!”: the frequency and clinical characteristics of people with knee osteoarthritis who report subjective knee swelling in the absence of objective swelling

To study the effects of knee osteoarthritis on hip flexibility among elders.

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