A prospective, single-blinded, bi-centric study and literature review to assess the need of C2ganglion (C2G) preservation-SAVIOUR's criteria ABSTRACT Objective: Joint manipulation for cranio-vertebral junction instability is often hindered by the C2ganglion (C2G). Our study aims to compare the surgical outcome among patients with or without C2G preservation and discuss the technical nuances. Methods: We did a prospective, bi-centric study and included all the operated patients of CVJ anomaly. The outcome was assessed by the Pain Numeric rating scale, Patient satisfactions score (PSS), and Stony Brook Scar Evaluation Scale. The fusion was assessed using Lenke fusion grade. Results: 171 patients [88 in Group A and 83 in Group B] were included. The most common symptom was spastic quadriparesis (n= 165, 96.5%) with median Nurick grade 3.3. Thirteen patients had suboccipital numbness and twelve patients had paraesthesia. Mean blood loss in Group A was 490 96.2 mL and Group B was 525 45.7 mL; median operative time was 217.9 and 162.2 minutes in the Group A and Group B respectively (p<0.05). At the follow-up (median 46.8 months) Lenke fusion grade A was achieved in 92.4% and grade B in 7.6%. A trend suggesting better functional outcomes (numbness, parestheisa, scar outcome and post-operative ulcer formation) in Group A was seen with all six patients, who underwent O-C2 fixation, developed pressure sore. Conclusion: Our results support ganglion preservation, especially in the subset of patients where occipital plating is required. Although the study fails to show any statistical significance, we suggest that, one should always start with an 'intent' of preservation as the functional outcome is better.