Knockdown of CBX7 inhibits ferroptosis in rats with cerebral ischemia and improves cognitive dysfunction by activating the Nrf2/HO-1 pathway

Zhang, Fan; Li, Fan; Xiao, Xiongxin

doi:10.1007/s12038-022-00275-6

Cited by 11 publications

(4 citation statements)

References 29 publications

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“…In addition to HIFs, NRF2, the master regulator of oxidative stress signaling, also plays an important role in hypoxia-induced ferroptosis. Many studies reported that NRF mediates the regulation of ferroptosis induced by hypoxia or H/R [ 124 , 125 , 128 , 138 ], while another group of studies reported that targeting NRF2 could inhibit hypoxia-or H/R-induced ferroptosis [ 149 , 160 , 161 , 162 , 163 , 164 , 165 , 166 ].…”

Section: Discussionmentioning

confidence: 99%

“…It was reported that chronic intermittent hypoxia (CIH) induced ferroptosis in the hippocampus, lung, liver, and cardiomyocytes by downregulating NRF2 and GPX4, as well as upregulating ACSL4, leading to cognitive impairment and injury of brain, lung liver, and heart [ 122 , 123 , 124 , 125 ]. In the brain, hypoxic-ischemic induces ferroptosis with the increased TFRC expression, and decreased expression of SLC7A11, TRX-1, and GPX4 [ 126 , 127 , 128 ]. A recent study showed that hypoxia and ischemia induce chromobox7 (CBX7) in neural progenitor cells, which promote ferroptosis through suppressing the NRF2/HO-1 signaling pathway [ 128 ].…”

Section: The Mechanism and Regulation Of Ferroptosis Modulated By Hyp...mentioning

confidence: 99%

“…In the brain, hypoxic-ischemic induces ferroptosis with the increased TFRC expression, and decreased expression of SLC7A11, TRX-1, and GPX4 [ 126 , 127 , 128 ]. A recent study showed that hypoxia and ischemia induce chromobox7 (CBX7) in neural progenitor cells, which promote ferroptosis through suppressing the NRF2/HO-1 signaling pathway [ 128 ]. In microglial BV-2 cells, hypoxia down-regulates GPX4 and SLC7A11 to induce ferroptosis, which can be reversed by the wild bitter melon extract [ 129 ].…”

Section: The Mechanism and Regulation Of Ferroptosis Modulated By Hyp...mentioning

confidence: 99%

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Ferroptosis Regulated by Hypoxia in Cells

Zheng

Liang

Zhang

2023

Cells

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Ferroptosis is an oxidative damage-related, iron-dependent regulated cell death with intracellular lipid peroxide accumulation, which is associated with many physiological and pathological processes. It exhibits unique features that are morphologically, biochemically, and immunologically distinct from other regulated cell death forms. Ferroptosis is regulated by iron metabolism, lipid metabolism, anti-oxidant defense systems, as well as various signal pathways. Hypoxia, which is found in a group of physiological and pathological conditions, can affect multiple cellular functions by activation of the hypoxia-inducible factor (HIF) signaling and other mechanisms. Emerging evidence demonstrated that hypoxia regulates ferroptosis in certain cell types and conditions. In this review, we summarize the basic mechanisms and regulations of ferroptosis and hypoxia, as well as the regulation of ferroptosis by hypoxia in physiological and pathological conditions, which may contribute to the numerous diseases therapies.

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Section: Discussionmentioning

confidence: 99%

Section: The Mechanism and Regulation Of Ferroptosis Modulated By Hyp...mentioning

confidence: 99%

Section: The Mechanism and Regulation Of Ferroptosis Modulated By Hyp...mentioning

confidence: 99%

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Ferroptosis Regulated by Hypoxia in Cells

Zheng

Liang

Zhang

2023

Cells

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“…The induction of the AMPK-Nrf2-NQO1 signaling pathway has been shown to protect hippocampal cells from oxygen–glucose deprivation-reoxygenation-induced injury [ 95 ]. Targeting chromobox 7, a transcriptional repressor, has been shown to influence Nrf2, HO-1, and NQO1 levels as well as behavioral and pathological outcomes in rat ischemic brains in vivo [ 191 ].…”

Section: The Involvement Of Nqo1 In Neurological Disordersmentioning

confidence: 99%

Impact of NQO1 dysregulation in CNS disorders

Yuhan,

Khaleghi Ghadiri,

Gorji

2024

J Transl Med

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NAD(P)H Quinone Dehydrogenase 1 (NQO1) plays a pivotal role in the regulation of neuronal function and synaptic plasticity, cellular adaptation to oxidative stress, neuroinflammatory and degenerative processes, and tumorigenesis in the central nervous system (CNS). Impairment of the NQO1 activity in the CNS can result in abnormal neurotransmitter release and clearance, increased oxidative stress, and aggravated cellular injury/death. Furthermore, it can cause disturbances in neural circuit function and synaptic neurotransmission. The abnormalities of NQO1 enzyme activity have been linked to the pathophysiological mechanisms of multiple neurological disorders, including Parkinson's disease, Alzheimer's disease, epilepsy, multiple sclerosis, cerebrovascular disease, traumatic brain injury, and brain malignancy. NQO1 contributes to various dimensions of tumorigenesis and treatment response in various brain tumors. The precise mechanisms through which abnormalities in NQO1 function contribute to these neurological disorders continue to be a subject of ongoing research. Building upon the existing knowledge, the present study reviews current investigations describing the role of NQO1 dysregulations in various neurological disorders. This study emphasizes the potential of NQO1 as a biomarker in diagnostic and prognostic approaches, as well as its suitability as a target for drug development strategies in neurological disorders.

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LncRNA RNA ROR Aggravates Hypoxia/Reoxygenation-Induced Cardiomyocyte Ferroptosis by Targeting miR-769-5p/CBX7 Axis

Lai,

Shen,

et al. 2023

Biochem Genet

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Knockdown of CBX7 inhibits ferroptosis in rats with cerebral ischemia and improves cognitive dysfunction by activating the Nrf2/HO-1 pathway

Cited by 11 publications

References 29 publications

Ferroptosis Regulated by Hypoxia in Cells

Ferroptosis Regulated by Hypoxia in Cells

Impact of NQO1 dysregulation in CNS disorders

LncRNA RNA ROR Aggravates Hypoxia/Reoxygenation-Induced Cardiomyocyte Ferroptosis by Targeting miR-769-5p/CBX7 Axis

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