Knockdown of circular RNA UBAP2 inhibits the malignant behaviours of esophageal squamous cell carcinoma by microRNA‐422a/Rab10 axis

Wu, Yu-Jen; Zhi, Lingran; Zhao, Ying; Yang, Lili; Cai, Fengmei

doi:10.1111/1440-1681.13269

Cited by 25 publications

(16 citation statements)

References 28 publications

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“…circUBAP2 is a well-known tumor-associated circRNA. Wu et al (16) indicated that circ-UBAP2 promoted the malignant behaviors of esophageal squamous cell carcinoma via the miR-422a/Rab10 axis. Zhao et al (17) found that circUBAP2 modulated pancreatic adenocarcinoma by regulating the infiltration and function of immune cells.…”

Section: Discussionmentioning

confidence: 99%

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Circular RNA UBAP2 promotes the proliferation of prostate cancer cells via the miR‑1244/MAP3K2 axis

Azhati

Wang

et al. 2021

Oncol Lett

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Prostate cancer (PCa) is a common male malignant disease with a high incidence, which can seriously affect the quality of life of patients. The survival rate of patients with PCa has improved to 98.6%; however, new insights for the molecular mechanism are still urgently required. Circular RNA (circ)UBAP2 is a tumor-associated circRNA that has been demonstrated to promote the progression of various types of cancer. CircUBAP2 has been demonstrated to be significantly upregulated in PCa, but its role in the progression of PCa remains unclear. The present study aimed to provide an improved understanding of the regulatory mechanism of circUBAP2 in PCa. circUBAP2 expression was identified to be upregulated in four PCa cell lines and clinical tissues by using reverse transcription-quantitative PCR analysis. Binding sites analysis and luciferase reporter gene assay indicated that the microRNA(miR)-1244/MAP3K2 axis was the target of circUBAP2. Gain-of-function assays revealed that circUBAP2 promoted the proliferation of PCa cells by sponging miR-1244 and promoting the MAP3K2 axis. The present findings may be essential for providing new strategies in the diagnosis and targeted therapy of PCa.

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Section: Discussionmentioning

confidence: 99%

“…Some circRNAs have already been considered as tumor-associated circRNAs, such as CDR1as, circUBAP2 and circPTV1 (14). Among these, circUBAP2 has been reported as a critical regulator involved in the progression of several types of cancer, such as ovarian cancer, esophageal squamous cell carcinoma and pancreatic adenocarcinoma (15)(16)(17).…”

Section: Introductionmentioning

confidence: 99%

Circular RNA UBAP2 promotes the proliferation of prostate cancer cells via the miR‑1244/MAP3K2 axis

Azhati

Wang

et al. 2021

Oncol Lett

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“…In this study, we focused on a new circRNA, circUBAP2 (hsa_circ_0003496), that functions in the trophoblast cell line HTR-8/SVneo and choriocarcinoma cell line JEG-3. circRNAs originate from the UBAP2 (ubiquitin-associated protein 2) gene, which includes hsa_circ_0003496 and has been reported to be upregulated in a variety of tumors [17][18][19]. However, it has not been reported in pregnancy-related diseases.…”

Section: Introductionmentioning

confidence: 99%

Decreased circUBAP2 Expression Is Associated with Preeclampsia by Limiting Trophoblast Cell Proliferation and Migration

Zhang

Shi

et al. 2021

Reprod. Sci.

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Preeclampsia (PE) is a common obstetric disease and a major cause of maternal, newborn, and fetal death. This condition is a multisystem disorder characterized by hypertension, proteinuria, and involvement of the kidney, liver, and nervous system. It is generally believed that the placenta is the main cause of PE. circRNAs are a special class of noncoding RNAs that can form covalently closed continuous ring structures with tissue-specific conservation, and they have been reported to play a wide range of regulatory functions in various diseases, including PE. In this study, we reported a novel circUBAP2 (hsa_circ_0003496) and found that it was downregulated in placental tissues from patients with PE compared to healthy controls. After knocking down circUBAP2 in trophoblast cells, we found that cell proliferation and migration were significantly suppressed. In addition, preliminary mechanistic studies showed that circUBAP2 can sponge miR-1244, and FOXM1 was identified as a target gene for miR-1244. Cotransfection of si-circUBAP2 and a miR-1244 inhibitor partially reversed the suppressive effect induced by circUBAP2 depletion on proliferation and migration. In conclusion, the circUBAP2/miR-1244/FOXM1 axis might be a promising molecular marker for the diagnosis and treatment of PE.

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“…Recent studies have found that the expression of Circ UBAP2 was up-regulated, which promoted the proliferation, migration and invasion of ESCC. Further studies on the mechanism have proved that circ UBAP2 might play the role of oncogenes by regulating the miR-422a/Rab10 axis of ESCC [55]. Compared with paracancerous tissues, the expressions of hsa_circ_0067934, circFNDC3B, circ-TTC17, hsa_circ_0006168, circPVT1 and hsa_circ_100873 were significantly up-regulated in EC tissues [39,40,42,43,56,57].…”

Section: Regulation Of Circrna On Proliferation Migration Invasionmentioning

confidence: 96%

Circular RNAs and esophageal cancer

et al. 2020

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As a new kind of RNA, circular RNA (circRNA) is a endogenous non-coding RNA with circular structure, which has the characteristics of universality, stability, conservatism and specificity. CircRNA can specifically bind to microRNAs (miRNAs) in the form of competitive endogenous RNA, thus directly or indirectly regulating the expression of related genes. In addition to the role of sponge, circRNA also regulates parental gene expression, transcriptional translation and protein modification; and it can be used as a biomarker to develop potential diagnosis and treatment methods and evaluate prognosis. Due to changes in dietary habits and genetic factors, the morbidity and mortality of esophageal cancer (EC) in the world are still high, and are prone to early metastasis. Although the diagnosis and treatment techniques have been improved in recent years, the early diagnosis of EC is not common, and the 5-year survival rate of patients is still very low. This article reviews the function and significance of circRNA and discusses the research progress of circRNA as biomarkers in EC.

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Knockdown of circular RNA UBAP2 inhibits the malignant behaviours of esophageal squamous cell carcinoma by microRNA‐422a/Rab10 axis

Cited by 25 publications

References 28 publications

Circular RNA UBAP2 promotes the proliferation of prostate cancer cells via the miR‑1244/MAP3K2 axis

Circular RNA UBAP2 promotes the proliferation of prostate cancer cells via the miR‑1244/MAP3K2 axis

Decreased circUBAP2 Expression Is Associated with Preeclampsia by Limiting Trophoblast Cell Proliferation and Migration

Circular RNAs and esophageal cancer

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