Knockdown of HNRNPA1 inhibits lung adenocarcinoma cell proliferation through cell cycle arrest at G0/G1 phase

Liu, Xianxun; Zhou, Yan; Lou, Yu‐Qing; Zhong, Hua

doi:10.1016/j.gene.2015.11.009

Cited by 61 publications

(57 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…HnRNPA1 is a major factor associated with various types of cancer and metastasis. This molecule is markedly overexpressed in lung cancer tissues and is associated with tumor proliferation [22]. Similarly, hnRNPA2/B1 is significantly upregulated in patients suffering from lung cancer and may be a marker for the early detection of lung cancer [23].…”

Section: Discussionmentioning

confidence: 99%

Serum exosomal hnRNPH1 mRNA as a novel marker for hepatocellular carcinoma

Dong

Chen

et al. 2017

Clinical Chemistry and Laboratory Medicine (CCLM)

102

View full text Add to dashboard Cite

Background: Distinctive exosomal contents could be useful for cancer diagnosis and prognosis. However, little is known about whether serum exosomal heterogeneous nuclear ribonucleoprotein H1 (hnRNPH1) mRNA is a satisfactory biomarker for hepatocellular carcinoma (HCC). Methods: Two hundred and ninety-one participants divided into four age-and gender-matched groups, including a HCC group (n = 88), a liver cirrhosis (LC) group (n = 67), a chronic hepatitis B (CHB) group (n = 68) and a healthy control group (n = 68), were enrolled. Serum exosomal hnRNPH1 mRNA and GAPDH mRNA were measured using TaqMan real-time PCR, and the relative expression levels were calculated. Receiver operating characteristic (ROC) curves were constructed to evaluate the effectiveness of hnRNPH1 mRNA alone and in combination with α-fetoprotein (AFP) in the diagnosis of HCC. The correlation between hnRNPH1 mRNA levels and clinicopathological characteristics and overall survival (OS) in HCC was determined. Results: The serum exosomal hnRNPH1 mRNA levels in HCC patients were remarkably higher than in the other groups (p < 0.05). The hnRNPH1 mRNA discriminated HCC from CHB with an area under the ROC curve (AUC) of 0.865, with sensitivity of 85.2% and specificity of 76.5% at cut-off value of 0.670. The AUC for hnRNPH1 mRNA in combination with AFP was further improved. The exosomal hnRNPH1 mRNA levels in HCC patients were associated with the Child-Pugh classification, portal vein tumor emboli, lymph node metastasis, TNM stage and OS (p < 0.05). Conclusions: These findings suggested that serum exosomal hnRNPH1 mRNA could be an effective marker for HCC in high HBV prevalence areas.

show abstract

Section: Discussionmentioning

confidence: 99%

Serum exosomal hnRNPH1 mRNA as a novel marker for hepatocellular carcinoma

Dong

Chen

et al. 2017

Clinical Chemistry and Laboratory Medicine (CCLM)

102

View full text Add to dashboard Cite

show abstract

“…Sarek et al demonstrated that tumor cell proliferation is regulated by different mechanisms other than telomerase regulation [ 9 ]. Research found that telomere-binding protein plays an important role in maintaining telomere stability and telomere length regulation [ 9 – 11 ].…”

Section: Discussionmentioning

confidence: 99%

Expression of Telomere Repeat Binding Factor 1 and TRF2 in Prostate Cancer and Correlation with Clinical Parameters

Chen

Wang

et al. 2017

BioMed Research International

View full text Add to dashboard Cite

Objective The objective of this study was to investigate the expression of telomere repeat binding factor 1 (TRF1) and TRF2 in prostate cancer and their relationships with clinicopathological features. Methods In total 50 prostate cancer tissues and paired benign prostate hyperplasia tissues were analyzed. The telomere-binding proteins TRF1 and TRF2 were measured using immunohistochemical method. Correlation analyses were used to evaluate the association between immunohistochemical score and clinical parameters. Results The expression of TRF1 was significantly higher in prostate cancer tissue than in benign prostate hyperplasia tissue (χ2 = 62.69, P < 0.01). Elevated levels of TRF2 were observed in both prostate cancer and benign prostate hyperplasia tissue (χ2 = 1.13, P = 0.76). TRF1 expression was significantly positively correlated with surgical capsular invasion (Spearman's r = 0.43, P = 0.002), seminal vesicle invasion (Spearman's r = 0.35, P = 0.01), lymph nodes metastases (Spearman's r = 0.41, P = 0.003), total prostate specific antigen (r = 0.61, P < 0.05), and Gleason score (r = 0.47, P = 0.01). However, there were no significant statistical differences between prostate volume (r = 0.06, P = 0.75) and age (r = 0.14, P = 0.09). Conclusion Both TRF1 and TRF2 were overexpressed in prostate cancer. There was no specificity of TRF2 in prostate cancer, while TRF1 may be associated with prostate cancer progression.

show abstract

“…The altered expression level of hnRNPs has been found in many types of cancer, suggesting their role in tumorigenesis. In lung cancer, hnRNP A1 expression was increased and was associated with tumor proliferation (X. Liu, Zhou, Lou, & Zhong, ). Several oncogenes, including KRAS , HRAS and a splice variant of Recepteur d'Origine Nantais (Δ RON ), have been identified as direct targets of hnRNP A1 (Jean‐Philippe, Paz, & Caputi, ).…”

Section: Rbp Function In Cancermentioning

confidence: 99%

Diverse roles of RNA‐binding proteins in cancer traits and their implications in gastrointestinal cancers

Masuda

Kuwano

2018

WIREs RNA

View full text Add to dashboard Cite

Gene expression patterns in cancer cells are strongly influenced by posttranscriptional mechanisms. RNA-binding proteins (RBPs) play key roles in posttranscriptional gene regulation; they can interact with target mRNAs in a sequence-and structure-dependent manner, and determine cellular behavior by manipulating the processing of these mRNAs. Numerous RBPs are aberrantly deregulated in many human cancers and hence, affect the functioning of mRNAs that encode proteins, implicated in carcinogenesis. Here, we summarize the key roles of RBPs in posttranscriptional gene regulation, describe RBPs disrupted in cancer, and lastly focus on RBPs that are responsible for implementing cancer traits in the digestive tract. These evidences may reveal a potential link between changes in expression/function of RBPs and malignant transformation, and a framework for new insights and potential therapeutic applications.

show abstract

Knockdown of HNRNPA1 inhibits lung adenocarcinoma cell proliferation through cell cycle arrest at G0/G1 phase

Cited by 61 publications

References 32 publications

Serum exosomal hnRNPH1 mRNA as a novel marker for hepatocellular carcinoma

Serum exosomal hnRNPH1 mRNA as a novel marker for hepatocellular carcinoma

Expression of Telomere Repeat Binding Factor 1 and TRF2 in Prostate Cancer and Correlation with Clinical Parameters

Diverse roles of RNA‐binding proteins in cancer traits and their implications in gastrointestinal cancers

Contact Info

Product

Resources

About