Knockdown of lncRNA GHET1 inhibits osteosarcoma cells proliferation, invasion, migration and EMT in vitro and in vivo

Yang, Wei; Shan, Zhiming; Zhou, Xinfang; Peng, Liangqun; Chai, Jing; Liu, Hongxing; Yang, Junmei; Zhang, Zhandong

doi:10.3233/cbm-181863

Cited by 20 publications

(22 citation statements)

References 31 publications

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“…EMT has been demonstrated to play a promoting role during tumor metastasis, and inhibition of EMT could suppress the migratory and invasive abilities of various cancer cells such as cholangiocarcinoma and ovarian cancer (31,32). Furthermore, some lncRNAs have been reported to be associated with EMT in different types of cancer (33,34). For example, lncRNA SNHG6 promoted lung cancer cell migration and invasion by increasing EMT (33).…”

Section: Discussionmentioning

confidence: 99%

Upregulation of cervical carcinoma expressed PCNA regulatory long non‑coding RNA promotes esophageal squamous cell carcinoma progression

et al. 2020

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Cervical carcinoma expressed PCNA regulatory long non-coding (lnc)RNA (CCEPR) has recently been reported to play oncogenic roles in some common types of human cancer. However, the clinical significance of CCEPR mRNA expression levels in esophageal squamous cell carcinoma (ESCC) and the exact function of CCEPR in regulating the malignant phenotypes of ESCC cells have not been previously investigated. In the present study, CCEPR mRNA expression level was upregulated in ESCC tissues and cell lines, and overexpression of CCEPR was associated with advanced TNM stage, lymph node metastasis, and poor prognosis in ESCC. In vitro experiments showed that silencing CCEPR mRNA expression levels significantly suppressed the proliferation, migration, and invasion of ESCC cells, while inducing ESCC cell apoptosis. Furthermore, inhibition of CCEPR decreased the protein expression levels of matrix metalloproteinase (MMP)2 and MMP9 and inhibited epithelial-mesenchymal transition in ESCC cells. In conclusion, the results showed that CCEPR plays an oncogenic role in ESCC and suggests that CCEPR could be used as a potential therapeutic target for ESCC treatment.

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Section: Discussionmentioning

confidence: 99%

Upregulation of cervical carcinoma expressed PCNA regulatory long non‑coding RNA promotes esophageal squamous cell carcinoma progression

et al. 2020

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“…As for lung cancer, Guan et al revealed that GHET1 depletion inhibited the proliferation, invasion, and epithelial-mesenchymal transition (EMT) of cancer cells by inhibiting the LATS1/YAP pathway [19]. Additionally, several studies have reported that GHET1 can promote EMT in esophageal squamous cell carcinoma, breast cancer, colorectal cancer, osteosarcoma, renal cell carcinoma, and bladder cancer [17,18,22,31,33,34]. Other studies have also shown that GHET1 promotes the progression of cancer and might be a therapeutic target of cancer [35,36].…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of long non-coding RNA GHET1 in cancers: a systematic review and meta-analysis

et al. 2020

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Background: A number of studies have demonstrated the critical role of long non-coding RNA gastric cancer high expressed transcript 1 (GHET1) in many cancers. This meta-analysis provides an evidence-based evaluation of the prognostic role of GHET1 in cancer. Materials and methods: Literature searches were conducted in several databases including Medline, Cochrane, EMBASE, CNKI, and Wanfang. The pooled odds ratio (OR) and hazard ratio (HR) with 95% confidence interval (CI) were used to evaluate the role of GHET1 in cancer. The study protocol was registered at PROSPERO (ID: CRD42018111252). Results: Sixteen studies, containing 1315 patients, were analyzed in this meta-analysis. The pooled results indicated that GHET1 overexpression was significantly associated with poor overall survival (OS) and disease-free survival (DFS) in cancer. Moreover, up-regulation of GHET1 expression predicted larger tumor size, positive lymph node metastasis, positive distant metastasis, and advanced TNM (tumor-node-metastases) stage in human cancers. Conclusion: There is a significant correlation between up-regulation of GHET1 and both poor prognosis and advanced clinicopathological cancer characteristics. GHET1 may be a potential prognostic predictor for human cancers.

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“…lncRNAs are one of these molecular markers, which can affect tumor genesis and development, and can easily collect biomarkers useful for monitoring and diagnosing tumors [31]. According to previous studies, lncRNA GHET1 has been proved to be an important oncogene in various human cancers, including NSCLC, HCC, BC, ESCC, HNC, BRC, GC, and PC [17][18][19][20][21][22][23][24][25][26]. It can be found based on the literature that lncRNA GHET1 may play an important role in cancer progression, which is achieved through regulating the LATS1/YAP signaling pathway and epithelial-mesenchymal transition (EMT).…”

Section: Discussionmentioning

confidence: 99%

“…Details of the study selection process are displayed in Figure 1. Eleven studies involving seven hundred and fourteen patients were enrolled in this meta-analysis according to the study exclusion and inclusion criteria [11,[17][18][19][20][21][22][23][24][25][26]. Table 1 summarizes the features of the eleven studies included in this meta-analysis.…”

Section: Study Characteristicsmentioning

confidence: 99%

Clinicopathological and Prognostic Value of Gastric Carcinoma Highly Expressed Transcript 1 in Cancer: A Meta-Analysis

Zhou

Fan

et al. 2020

Journal of Oncology

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Background. Long noncoding RNA gastric cancer highly expressed transcript 1 (lncRNA GHET1) is often reported to be abnormally expressed in multiple cancers, but the situation is different in different cancers. Therefore, a meta-analysis is necessary to clarify the value of lncRNA GHET1 as a prognostic indicator in cancer. Methods. Relevant research studies on lncRNA GHET1 and cancer were retrieved from three electronic literature databases of Web of Science, PubMed, and OVID. Meanwhile, hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated to explore the relationship between lncRNA GHET1 expression and survival of cancer patients. The odds ratios (ORs) and 95% CIs were calculated to assess the association of lncRNA GHET1 expression with pathological parameters of cancer patients. Results. The meta-analysis included a total of 11 studies involving 714 cancer patients. The pooled HR suggests that high lncRNA GHET1 expression is associated with poor overall survival. In addition, high expression of lncRNA GHET1 was found to be associated with larger tumor size, poor histological grade, high tumor stage, lymph node metastasis, and distant metastasis. Conclusions. High lncRNA GHET1 expression can predict poor survival and pathological parameters. And lncRNA GHET1 could serve as a new indicator in multiple cancers.

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Knockdown of lncRNA GHET1 inhibits osteosarcoma cells proliferation, invasion, migration and EMT in vitro and in vivo

Cited by 20 publications

References 31 publications

Upregulation of cervical carcinoma expressed PCNA regulatory long non‑coding RNA promotes esophageal squamous cell carcinoma progression

Upregulation of cervical carcinoma expressed PCNA regulatory long non‑coding RNA promotes esophageal squamous cell carcinoma progression

Prognostic value of long non-coding RNA GHET1 in cancers: a systematic review and meta-analysis

Clinicopathological and Prognostic Value of Gastric Carcinoma Highly Expressed Transcript 1 in Cancer: A Meta-Analysis

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