Knockdown of lncRNA Meg3 delays the onset of puberty in female rats

Li, Hailing; Ren, Chunhuan; Lu, Juntai; Xu, Shuangshuang; Gong, Xinbao; Zhang, Wei; Yan, Xu; Ye, Jing; Qin, Ping; Liu, Ya; Li, Yunsheng; Zhang, Yunhai; Fang, Fugui

doi:10.1016/j.theriogenology.2023.05.026

Cited by 5 publications

(3 citation statements)

References 39 publications

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“…Currently, lncRNAs have been widely reported to be involved in embryonic development ( 12 ), muscle development ( 13 ), metabolism ( 14 ), and reproductive regulation ( 15 ). Recent research has demonstrated that lncRNA Meg3 can regulate the expression of GnRH and Kiss-1 in hypothalamic cells, and knockdown of lncRNA Meg3 can delay puberty in female rats ( 16 ). Additionally, the lncRNA MSTRG.33887.2 has the potential to influence goat reproduction by regulating target genes involved in hypothalamic folate metabolism and energy metabolism homeostasis ( 17 ).…”

Section: Introductionmentioning

confidence: 99%

Transcriptome analysis revealed the characteristics and functions of long non-coding RNAs in the hypothalamus during sexual maturation in goats

Li,

Chao,

Wang

et al. 2024

Front. Vet. Sci.

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The hypothalamus is an essential neuroendocrine area in animals that regulates sexual development. Long non-coding RNAs (lncRNAs) are hypothesized to regulate physiological processes related to animal reproduction. However, the regulatory mechanism by which lncRNAs participate in sexual maturity in goats is poorly known, particularly from birth to sexual maturation. In this study, RNAseq analysis was conducted on the hypothalamus of four developmental stages (1day (D1, n = 5), 2 months (M2, n = 5), 4 months (M4, n = 5), and 6 months (M6, n = 5)) of Jining grey goats. The results showed that a total of 237 differentially expressed lncRNAs (DELs) were identified in the hypothalamus. Among these, 221 DELs exhibited cis-regulatory effects on 693 target genes, while 24 DELs demonstrated trans-regulatory effects on 63 target genes. The target genes of these DELs are mainly involved in biological processes related to energy metabolism, signal transduction and hormone secretion, such as sphingolipid signaling pathway, adipocytokine signaling pathway, neurotrophic signaling pathway, glutamatergic synapse, P53 signaling pathway and GnRH signaling pathway. In addition, XR_001918477.1, TCONS_00077463, XR_001918760.1, and TCONS_00029048 and their potential target genes may play a crucial role in the process of goat sexual maturation. This study advances our understanding of lncRNA in hypothalamic tissue during sexual maturation in goats and will give a theoretical foundation for improving goat reproductive features.

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Section: Introductionmentioning

confidence: 99%

Transcriptome analysis revealed the characteristics and functions of long non-coding RNAs in the hypothalamus during sexual maturation in goats

Li,

Chao,

Wang

et al. 2024

Front. Vet. Sci.

View full text Add to dashboard Cite

show abstract

“…Currently, lncRNAs have been widely reported to be involved in embryonic development (12), muscle development (13), metabolism (14), and reproductive regulation (15). Recent research has demonstrated that lncRNA Meg3 can regulate the expression of GnRH and Kiss-1 in hypothalamic cells, and knockdown of lncRNA Meg3 can delay puberty in female rats (16). Additionally, the lncRNA MSTRG.33887.2 has the potential to influence goat reproduction by regulating target genes involved in hypothalamic folate metabolism and energy metabolism homeostasis (17).…”

Section: Introductionmentioning

confidence: 99%

Table_7.XLSX

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“…Currently, lncRNAs have been widely reported to be involved in embryonic development (12), muscle development (13), metabolism (14), and reproductive regulation (15). Recent research has demonstrated that lncRNA Meg3 can regulate the expression of GnRH and Kiss-1 in hypothalamic cells, and knockdown of lncRNA Meg3 can delay puberty in female rats (16). Additionally, the lncRNA MSTRG.33887.2 has the potential to influence goat reproduction by regulating target genes involved in hypothalamic folate metabolism and energy metabolism homeostasis (17).…”

Section: Introductionmentioning

confidence: 99%

Table_5.XLSX

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Knockdown of lncRNA Meg3 delays the onset of puberty in female rats

Cited by 5 publications

References 39 publications

Transcriptome analysis revealed the characteristics and functions of long non-coding RNAs in the hypothalamus during sexual maturation in goats

Transcriptome analysis revealed the characteristics and functions of long non-coding RNAs in the hypothalamus during sexual maturation in goats

Table_7.XLSX

Table_5.XLSX

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