Knockdown of lncRNA MIR31HG inhibits cell proliferation in human HaCaT keratinocytes

Gao, Jintao; Chen, Fangru; Hua, Mingchun; Guo, Junfan; Nong, Yuejuan; Tang, Qinyan; Zhong, Fengxia; Qin, Linxiu

doi:10.1186/s40659-018-0181-8

Cited by 32 publications

(24 citation statements)

References 26 publications

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“…MIR31HG silencing has suppressed proliferation of keratinocytes and prompted cell cycle arrest in the G2/M phase. Up-regulation of MIR31HG has been shown to be associated with NF-κB [ 17 ]. Table 2 shows the list of lncRNAs whose expression has been up-regulated in the psoriasis.…”

Section: Lncrnas and Psoriasismentioning

confidence: 99%

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The eminent roles of ncRNAs in the pathogenesis of psoriasis

Ghafouri‐Fard

Eghtedarian

Taheri

et al. 2020

Non-coding RNA Research

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Psoriasis is a chronic immune-related disorder in which both genetic and environmental parameters are involved. Recent studies have demonstrated dysregulation of long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) in the peripheral blood or skin lesions of patients with psoriasis. While a number of lncRNAs such as MEG3, AL162231.4 and NONHSAT044111 have been down-regulated in the course of psoriasis, others including PRINS, MIR31HG, RP6‐65G23.1, MSX2P1, SLC6A14-1:1, NR_003062 have been up-regulated. Moreover, expressions of several miRNAs have been dysregulated in this disorder. Among dysregulated miRNAs are miR-126, miR-143, miR-19a and miR-155 whose diagnostic roles in the psoriasis have also been assessed. Dysregulated non-coding RNAs in this disorder participate in the regulation of chemokine signaling pathway and immune response, control of epidermal development and skin barrier as well as modulation of function of certain subsets of T cells. Besides, these transcripts possibly regulate activity of NF-κΒ, mTOR, MAPK and JAK-STAT signaling pathways. Besides, expression levels of circRNAs have been decreased in the psoriasis lesions. Massive alterations in the levels of lncRNAs and miRNAs in the psoriasis lesions or peripheral blood of affected individuals show participation of these transcripts in the pathogenesis of this disorder.

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Section: Lncrnas and Psoriasismentioning

confidence: 99%

“…MIR31HG expression depends on NF-κB activation. [ 17 ] RP6‐65G23.1 HaCaT cell, a human skin epithelial cell line, and Human Normal Primary Epidermal Keratinocytes (HEKn) were used. M5, a cocktail of cytokines, was used to induce psoriatic inflammation like condition in HaCaT cells and primary keratinocytes.…”

Section: Lncrnas and Psoriasismentioning

confidence: 99%

The eminent roles of ncRNAs in the pathogenesis of psoriasis

Ghafouri‐Fard

Eghtedarian

Taheri

et al. 2020

Non-coding RNA Research

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“…121 Similarly, lncRNA MIR31HG is upregulated in psoriatic lesions and influences keratinocyte proliferation through G2/M cell cycle arrest. 122 In addition, lncRNA-MSX2P1 is upregulated in IL-22-treated keratinocytes and induces increased cell proliferation and expression of S100A7 through suppression of miR-6731-5p. 123 Psoriasis susceptibility-related RNA gene induced by stress (PRINS) is another important lncRNA that has been implicated in the pathogenesis of psoriasis.…”

Section: Long Non-coding Rnamentioning

confidence: 99%

Dysregulated epigenetic modifications in psoriasis

Zeng

Tsoi

Gudjonsson

2021

Experimental Dermatology

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The observed incidence of psoriasis has been gradually increasing over time (J Am Acad Dermatol, 03, 2009, 394), but the underlying pathogenic factors have remained unclear. Recent studies suggest the importance of epigenetic modification in the pathogenesis of psoriasis. Aberrant epigenetic patterns including changes in DNA methylation, histone modifications and non-coding RNA expression are observed in psoriatic skin. Reversing these epigenetic mechanisms has showed improvement in psoriatic phenotypes, making epigenetic therapy a potential avenue for psoriasis treatment. Here, we summarize relevant evidence for epigenetic dysregulation contributing to psoriasis susceptibility and pathogenesis, and the factors responsible for epigenetic modifications, providing directions for potential future clinical avenues.

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“…MIR31HG thus plays a decisive role in the regulation of excessive proliferation of psoriatic KCs and may be a potential therapeutic target. [ 15 ]…”

Section: Lncrnas and Psoriasismentioning

confidence: 99%

An update on the role of long non-coding RNAs in psoriasis

Song

et al. 2020

Chinese Medical Journal

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Increasing evidence suggests that long non-coding RNAs (lncRNAs) are of vital importance for various biological processes, and dysregulation of lncRNAs is frequently associated with various diseases such as psoriasis. LncRNAs modulate gene expression at the transcriptional, post-transcriptional, and translational levels; however, the specific regulatory mechanisms of lncRNAs in psoriasis remain largely unexplored. This review provides an overview of recent studies investigating mechanisms and functions of lncRNAs in psoriasis, especially focusing on the role of lncRNAs in keratinocytes, T cells, and dendritic cells.

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Knockdown of lncRNA MIR31HG inhibits cell proliferation in human HaCaT keratinocytes

Cited by 32 publications

References 26 publications

The eminent roles of ncRNAs in the pathogenesis of psoriasis

The eminent roles of ncRNAs in the pathogenesis of psoriasis

Dysregulated epigenetic modifications in psoriasis

An update on the role of long non-coding RNAs in psoriasis

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