Knockdown of long noncoding RNA-taurine-upregulated gene 1 inhibits tumor angiogenesis in ovarian cancer by regulating leucine-rich α-2-glycoprotein-1

RETRACTED: Long noncoding RNA TUG1 facilitates cell ovarian cancer progression through targeting MiR‐29b‐3p/MDM2 axis

“…All data were performed as the mean ± SD. **p < .01, ***p < .001 tumor development by regulating cell proliferation, cell cycle, migration, invasion, apoptosis, angiogenesis, chemical-resistant, and EMT (Fan, Li, et al, 2019;Kuang et al, 2016;Li, Gan, Qin, Jiao, & Shi, 2017).…”

“…A variety of studies demonstrated that TUG1 is highly expressed in multiple cancers, and it has been found to contribute to carcinogenesis in laryngocarcinoma (Zhuang, Liu, & Wu, 2019), osteosarcoma (Yu, Hu, et al, 2019), multiple myeloma (Liu, Wang, & Liu, 2019), pancreatic cancer (Hui et al, 2019), melanoma (Wang, Liu, Ren, Wang, & Liu, 2019), and OC (Fan, Li, et al, 2019). Previous studies have illustrated that TUG1 promotes cancer progression by regulating LRG1 secretion through modulating tumor growth factor‐β pathway (Fan, Li, et al, 2019), and by promoting cell proliferation and invasion through regulating WNT/β‐catenin pathway (Liu et al, 2018). Additionally, TUG1 promotes cancer progression through accelerating cell proliferation and inhibiting cell apoptosis (Kuang, Zhang, Hua, Dong, & Li, 2016; Li, Chen, Zhang, & Liu, 2018; Li, Zhang, Liu, & Chen, 2018).…”

“…It has also been reported that TUG1 promotes multiple myeloma cell proliferation and inhibits apoptosis by suppressing miR‐29b‐3p (Liu, Wang, & Liu, 2019), and TUG1 induces cardiac hypertrophy through sponging miR‐29b‐3p (Zou, Wang, Tang, & Wen, 2019). Moreover, TUG1 promotes OC cell proliferation and invasion by regulating WNT/β‐catenin pathway (Liu, Liu et al, 2018), or regulates angiogenesis by regulating expression of LRG1 (Fan, Li, et al, 2019). Besides, TUG1 promotes OC cell proliferation, metastasis, and inhibits apoptosis through regulating multiple signaling pathways (Kuang et al, 2016; Li, Chen, et al, 2018; Plantin, Sassolas, Guillet, Tater, & Guillet, 1988).…”

Role of taurine, its haloamines and its lncRNA TUG1 in both inflammation and cancer progression. On the road to therapeutics? (Review)

“…In more depth, the increased activity of SIRT1 protein appeared to be pronounced in inhibiting the expression of epithelial markers such as E-cadherin, in turn exerting a positive effect on the Wnt/β-catenin signaling pathway, through a positive feedback loop (382). In line with the above, additional experiments showed that lncRNA TUG1 caused the increased invasion of human umbilical vein endothelial cells (HUVECs), by upregulating leucine-rich alpha-2-glycoprotein 1 (LRG1) secretion through transforming growth factor-beta (TGF-β) pathway (383), confirming its oncogenic role. In particular, both SKOV3 and CAOV3 endothelial cell lines presented strong pro-angiogenic effects via Smad1/5/8 signaling pathways, thereby leading to binding of LRG1 protein to TGF-β accessory receptor (384).…”

LncRNA HCG11/miR‐26b‐5p/QKI5 feedback loop reversed high glucose‐induced proliferation and angiogenesis inhibition of HUVECs

“…Hyperglycaemia is known to impair endothelial cells (ECs) angiogenesis, such as in diabetic retinopathy (DR) or myocardial infarction (MI) 4‐6 . Regarding the mechanism of angiogenesis, many angiogenic factors and signalling pathways have been shown to regulate blood vessel growth and morphogenesis 7 . Recent studies have revealed important functions of lncRNAs in angiogenesis and cardio‐cerebrovascular disease 8 …”