Knockdown of RhoQ, a member of Rho GTPase, accelerates TGF-β-induced EMT in human lung adenocarcinoma

Satoh, Kotone; Sakai, Satoshi; Nishizuka, Makoto

doi:10.1016/j.bbrep.2022.101346

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2023

2024

Publication Types

Select...

Other1

Article1

Relationship

Self Cite0

Independent2

Authors

Journals

Cited by 2 publications

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Screening dilated cardiomyopathy core genes for pan-cancer analysis by machine learning

Li,

Wang,

Wang

2023

Proceedings of the 2023 4th International Symposium on Artificial Intelligence for Medicine Science

View full text Add to dashboard Cite

Screening dilated cardiomyopathy core genes for pan-cancer analysis by machine learning

Li,

Wang,

Wang

2023

Proceedings of the 2023 4th International Symposium on Artificial Intelligence for Medicine Science

View full text Add to dashboard Cite

Cycloalliin, an Organosulfur Compound in Garlic, Inhibits EMT and Invasion of the A549 Non-Small Cell Lung Cancer Cell Line

Sasaki,

Yamaya,

Notoya

et al. 2024

BPB Reports

View full text Add to dashboard Cite

Non-small cell lung cancer (NSCLC) accounts for 80%-90% of all lung cancers. The metastasis of NSCLC has a considerable impact on prognosis and systemic status. Cycloalliin, an organosulfur compound found in garlic, is known for its health benefits on cardiovascular disease and obesity. However, the role of cycloalliin in cancer cell invasion and metastasis remains unknown. In this study, we investigated the effect of cycloalliin on the epithelial-to-mesenchymal transition (EMT) and invasiveness of the NSCLC cell line A549. Cycloalliin inhibited transforming growth factor (TGF)-β-induced EMT and invasive potential of A549 cells. Furthermore, we found that cycloalliin suppressed Smad3 phosphorylation and expression of Snail, a transcription factor that promotes EMT, during the early stages of TGF-β-mediated EMT. This study provides valuable insights into the inhibitory potential of cycloalliin on EMT, suggesting that this compound may have a therapeutic role against EMT in NSCLC cells.

show abstract

Knockdown of RhoQ, a member of Rho GTPase, accelerates TGF-β-induced EMT in human lung adenocarcinoma

Cited by 2 publications

References 38 publications

Screening dilated cardiomyopathy core genes for pan-cancer analysis by machine learning

Screening dilated cardiomyopathy core genes for pan-cancer analysis by machine learning

Cycloalliin, an Organosulfur Compound in Garlic, Inhibits EMT and Invasion of the A549 Non-Small Cell Lung Cancer Cell Line

Contact Info

Product

Resources

About