Knockdown of tissue nonspecific alkaline phosphatase impairs neural stem cell proliferation and differentiation

Kermer, Vanessa; Ritter, Mathias; Albuquerque, Boris; Leib, Christoph; Stanke, Matthias; Zimmermann, Herbert

doi:10.1016/j.neulet.2010.09.013

Cited by 57 publications

(35 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…TNAP was also found to be essential for the differentiation of cultured adult neural stem cells into neurons or oligodendrocytes. However, the involvement of purinergic mechanisms was not ascertained [584]. Activation of downstream signaling mediated by antibody ligation as observed for eN has not been described for APs.…”

Section: Downstream Signalingmentioning

confidence: 98%

Cellular function and molecular structure of ecto-nucleotidases

Zimmermann

Zebisch

Sträter

2012

Purinergic Signalling

Self Cite

888

922

View full text Add to dashboard Cite

Ecto-nucleotidases play a pivotal role in purinergic signal transmission. They hydrolyze extracellular nucleotides and thus can control their availability at purinergic P2 receptors. They generate extracellular nucleosides for cellular reuptake and salvage via nucleoside transporters of the plasma membrane. The extracellular adenosine formed acts as an agonist of purinergic P1 receptors. They also can produce and hydrolyze extracellular inorganic pyrophosphate that is of major relevance in the control of bone mineralization. This review discusses and compares four major groups of ectonucleotidases: the ecto-nucleoside triphosphate diphosphohydrolases, ecto-5′-nucleotidase, ecto-nucleotide pyrophosphatase/phosphodiesterases, and alkaline phosphatases. Only recently and based on crystal structures, detailed information regarding the spatial structures and catalytic mechanisms has become available for members of these four ecto-nucleotidase families. This permits detailed predictions of their catalytic mechanisms and a comparison between the individual enzyme groups. The review focuses on the principal biochemical, cell biological, catalytic, and structural properties of the enzymes and provides brief reference to tissue distribution, and physiological and pathophysiological functions.

show abstract

Section: Downstream Signalingmentioning

confidence: 98%

Cellular function and molecular structure of ecto-nucleotidases

Zimmermann

Zebisch

Sträter

2012

Purinergic Signalling

Self Cite

888

922

View full text Add to dashboard Cite

show abstract

“…According to recent evidence, TNSALP seems involved in central nervous system development (e.g., proliferation and differentiation of neural stem cells, maturation and function of synapses, myelination) and in different brain functions [4,10,17], and these actions may have a role in the variety of neurological and psychological signs and symptoms (from neonatal seizures to chronic pain, anxiety, restlessness, and depression) that are frequently seen in the different forms of HPP. The occurrence of inflammation (osteomyelitis, arthritis) and muscle, bone, and cartilage damage in HPP also suggests a possible role of TNSALP in inflammatory processes [4].…”

Section: Alkaline Phosphatasementioning

confidence: 99%

Hypophosphatasia: an overview of the disease and its treatment

Bianchi

2015

Osteoporos Int

108

View full text Add to dashboard Cite

This review presents the current knowledge on hypophosphatasia, a rare genetic disease of very variable severity (from lethal to mild) and clinical presentation, caused by defective production of tissue-non-specific alkaline phosphatase (TNSALP). Hypophosphatasia can affect babies in utero as well as infants, children, and adults. The article first presents the genetics of TNSALP and its many known mutations underlying the disease. Then, it presents the epidemiology, classification, and clinical presentation of the six different forms of the disease (perinatal lethal, prenatal benign, infantile, childhood, adult, and odontohypophosphatasia) as well as the essential diagnostic clues. The last section on treatment presents a survey of the therapeutic approaches, up to the ongoing phase 2 studies of enzyme replacement therapy.

show abstract

“…1D). Matings between Sox2 loxP/loxP and Sox2 lacZ/þ ;TNAP Cre resulted in the birth of live pups at normal Mendelian rates, even though all the Sox2 loxP/lacZ ;TNAPCre mice died within 2 weeks after birth for unknown reasons, possibly due to TNAP Cre -driven Sox2 deletion in other tissues essential for postnatal survival, such as neural stem cells [31].…”

Section: Sox2 Is Required For Pgc Development and Pluripotencymentioning

confidence: 99%

Essential Role of Sox2 for the Establishment and Maintenance of the Germ Cell Line

et al. 2013

View full text Add to dashboard Cite

Sox2 is a pluripotency-conferring gene expressed in primordial germ cells (PGCs) and postnatal oocytes, but the role it plays during germ cell development and early embryogenesis is unknown. Since Sox2 ablation causes early embryonic lethality shortly after blastocyst implantation, we generated mice bearing Sox2-conditional deletion in germ cells at different stages of their development through the Cre/loxP recombination system. Embryos lacking Sox2 in PGCs show a dramatic decrease of germ cell numbers at the time of their specification. At later stages, we found that Sox2 is strictly required for PGC proliferation. On the contrary, Sox2 deletion in meiotic oocytes does not impair postnatal oogenesis and early embryogenesis, indicating that it is not essential for oocyte maturation or for zygotic development. We also show that Sox2 regulates Kit expression in PGCs and binds to discrete transcriptional regulatory sequences of this gene, which is known to be important for PGCs survival and proliferation. Sox2 also stimulates the expression of Zfp148, which is required for normal development of fetal germ cells, and Rif1, a potential regulator of PGC pluripotency.

show abstract

Knockdown of tissue nonspecific alkaline phosphatase impairs neural stem cell proliferation and differentiation

Cited by 57 publications

References 28 publications

Cellular function and molecular structure of ecto-nucleotidases

Cellular function and molecular structure of ecto-nucleotidases

Hypophosphatasia: an overview of the disease and its treatment

Essential Role of Sox2 for the Establishment and Maintenance of the Germ Cell Line

Contact Info

Product

Resources

About