Knockdown of TRIM47 inhibits glioma cell proliferation, migration and invasion through the inactivation of Wnt/β-catenin pathway

Li, Mengdan; Li, Qi; Xu, Min; Zhong, Wenting

doi:10.1016/j.mcp.2020.101623

Cited by 22 publications

(17 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…TRIM47 expression was shown to have a prognostic value in gliomas as a marker for poorer overall survival (OS). In addition, TRIM47 knockdown hampered the proliferative, invasive, and migratory potential of glioma cells in line with previous work by Chen et al [ 90 , 91 ].…”

Section: Trim Proteins In Brain Tumorssupporting

confidence: 87%

“…Moreover, it was shown that the effects of TRIM47 knockdown were mediated by the Wnt/b-catenin pathway. While downregulation of TRIM47 lowered the expression levels of β-catenin, c-MYC, and cyclin D1, exogenous activation of Wnt/β-catenin signaling ( Figure 2 a) abolished the previous effects of TRIM47 knockdown observed in glioma cells [ 90 ]. Furthermore, Ji et al showed that TRIM47 expression was higher in GBM and low-grade glioma specimens compared to normal brain and also correlated positively with the malignancy grade [ 91 ].…”

Section: Trim Proteins In Brain Tumorsmentioning

confidence: 99%

See 1 more Smart Citation

Emerging Roles of TRIM Family Proteins in Gliomas Pathogenesis

Giannopoulou

Xanthopoulos

Piperi

et al. 2022

Cancers

View full text Add to dashboard Cite

Gliomas encompass a vast category of CNS tumors affecting both adults and children. Treatment and diagnosis are often impeded due to intratumor heterogeneity and the aggressive nature of the more malignant forms. It is therefore essential to elucidate the molecular mechanisms and explore the intracellular signaling pathways underlying tumor pathology to provide more promising diagnostic, prognostic, and therapeutic tools for gliomas. The tripartite motif-containing (TRIM) superfamily of proteins plays a key role in many physiological cellular processes, including brain development and function. Emerging evidence supports the association of TRIMs with a wide variety of cancers, exhibiting both an oncogenic as well as a tumor suppressive role depending on cancer type. In this review, we provide evidence of the pivotal role of TRIM proteins in gliomagenesis and exploit their potential as prognostic biomarkers and therapeutic targets.

show abstract

Section: Trim Proteins In Brain Tumorssupporting

confidence: 87%

Section: Trim Proteins In Brain Tumorsmentioning

confidence: 99%

Emerging Roles of TRIM Family Proteins in Gliomas Pathogenesis

Giannopoulou

Xanthopoulos

Piperi

et al. 2022

Cancers

View full text Add to dashboard Cite

show abstract

“…Regarding tumor resistance, TRIM11-mediated drug resistance depends on activating β-catenin/ABCC9 signaling by facilitating the degradation of Daple in NPC [ 46 ]. Moreover, TRIM15 [ 238 ], TRIM24 [ 32 ], TRIM37 [ 239 ], and TRIM47 [ 240 ] were demonstrated to positively modulate β-catenin pathways.…”

Section: The Trim Family and Cancer Pathologymentioning

confidence: 99%

TRIM family contribute to tumorigenesis, cancer development, and drug resistance

et al. 2022

View full text Add to dashboard Cite

The tripartite-motif (TRIM) family represents one of the largest classes of putative single protein RING-finger E3 ubiquitin ligases. TRIM family is involved in a variety of cellular signaling transductions and biological processes. TRIM family also contributes to cancer initiation, progress, and therapy resistance, exhibiting oncogenic and tumor-suppressive functions in different human cancer types. Moreover, TRIM family members have great potential to serve as biomarkers for cancer diagnosis and prognosis. In this review, we focus on the specific mechanisms of the participation of TRIM family members in tumorigenesis, and cancer development including interacting with dysregulated signaling pathways such as JAK/STAT, PI3K/AKT, TGF-β, NF-κB, Wnt/β-catenin, and p53 hub. In addition, many studies have demonstrated that the TRIM family are related to tumor resistance; modulate the epithelial–mesenchymal transition (EMT) process, and guarantee the acquisition of cancer stem cells (CSCs) phenotype. In the end, we havediscussed the potential of TRIM family members for cancer therapeutic targets.

show abstract

“…Knockdown of TRIM15 in esophageal squamous cell carcinoma (ESCC) cells significantly inhibited the proliferation, migration and invasion of cells by suppressing the Wnt/β-catenin signaling pathway (Zhang et al, 2021). Knockdown of TRIM47 significantly inhibited the activation of the Wnt/β-catenin pathway in U87 and U251 cells and thus attenuated the proliferation and metastasis of glioma cells in vitro and in vivo (Chen et al, 2020). TRIM66 is involved in the regulation of GSK-3β phosphorylation and β-catenin expression and acts as an oncoprotein in HCC by activating the GSK-3β-dependent Wnt/β-catenin signaling (Fan et al, 2019).…”

Section: Trims and Other Signaling Pathwaysmentioning

confidence: 99%

The roles and targeting options of TRIM family proteins in tumor

Zhang

Zhang²,

Zheng³

et al. 2022

Front. Pharmacol.

View full text Add to dashboard Cite

Tripartite motif (TRIM) containing proteins are a class of E3 ubiquitin ligases, which are critically implicated in the occurrence and development of tumors. They can function through regulating various aspects of tumors, such as tumor proliferation, metastasis, apoptosis and the development of drug resistance during tumor therapy. Some members of TRIM family proteins can mediate protein ubiquitination and chromosome translocation via modulating several signaling pathways, like p53, NF-κB, AKT, MAPK, Wnt/β-catenin and other molecular regulatory mechanisms. The multi-domain nature/multi-functional biological role of TRIMs implies that blocking just one function or one domain might not be sufficient to obtain the desired therapeutic outcome, therefore, a detailed and systematic understanding of the biological functions of the individual domains of TRIMs is required. This review mainly described their roles and underlying mechanisms in tumorigenesis and progression, and it might shade light on a potential targeting strategy for TRIMs in tumor treatment, especially using PROTACs.

show abstract

Knockdown of TRIM47 inhibits glioma cell proliferation, migration and invasion through the inactivation of Wnt/β-catenin pathway

Cited by 22 publications

References 25 publications

Emerging Roles of TRIM Family Proteins in Gliomas Pathogenesis

Emerging Roles of TRIM Family Proteins in Gliomas Pathogenesis

TRIM family contribute to tumorigenesis, cancer development, and drug resistance

The roles and targeting options of TRIM family proteins in tumor

Contact Info

Product

Resources

About