Knoevenagel Condensation Reactions of Cyano Malononitrile-Derivatives Under Microwave Radiation

Zanin, Lucas Lima; Jimenez, David Esteban Quintero; Fonseca, Luís; Porto, André Luiz Meleiro

doi:10.2174/1385272822666180123145819

Cited by 12 publications

(4 citation statements)

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“…A comprehensive review on reactions of cyano malononitrile-derivatives under Microwave Radiation was also reported recently [41]. The Knoevenagel condensation between aromatic aldehydes or ketones and malonic acid in the presence of tetrabutyl ammonium bromide and K2CO3 was carried out and reported by Gupta and Wakhloo 2007 under microwave irradiation in water.…”

Section: F Condensation Reactionmentioning

confidence: 99%

Microwave Assisted Synthesis of Organic Compounds and Nanomaterials

Jha¹

2021

Nanofibers - Synthesis, Properties and Applications

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In the Conventional laboratory or industry heating technique involve Bunsen burner, heating mental/hot plates and electric heating ovens. To produce a variety of useful compounds for betterment of mankind, the Microwave Chemistry was introduced in year 1955 and finds a place in one of the Green chemistry method. In Microwave chemistry is the science of applying microwave radiation to chemical reactions. Microwaves act as high frequency electric fields and will generally heat any material containing mobile electric charges, such as polar molecules in a solvent or conducting ions in a solid. Polar solvents are heated as their component molecules are forced to rotate with the field and lose energy in collisions i.e. the dipole moments of molecules are important in order to proceed with the chemical reactions in this method. It can be termed as microwave-assisted organic synthesis (MAOS), Microwave-Enhanced Chemistry (MEC) or Microwave-organic Reaction Enhancement synthesis (MORE). Microwave-Assisted Syntheses is a promising area of modern Green Chemistry could be adopted to save the earth.

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Section: F Condensation Reactionmentioning

confidence: 99%

Microwave Assisted Synthesis of Organic Compounds and Nanomaterials

Jha¹

2021

Nanofibers - Synthesis, Properties and Applications

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“…Knoevenagel adducts, easily prepared from aromatic aldehydes and malononitrile in the presence of a base, were valuable substrates for various types of reactions such as Michael addition, cycloaddition reaction, reductive reaction, domino reaction, etc. [ 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 ]. Although the above work is excellent, it is still necessary to further expand the reaction range of istain N , N ′-cyclic azomethine imines by using N -unsubstituted azomethine imines and 2-arylidenemalononitriles.…”

Section: Introductionmentioning

confidence: 99%

K2CO3-Promoted Formal [3+3]-Cycloaddition of N-Unsubstituted Isatin N,N′-Cyclic Azomethine Imine 1,3-Dipoles with Knoevenagel Adducts

Yang

Li²,

Wang

et al. 2023

Molecules

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The synthesis of dicyclic spiropyridazine oxoindole derivatives by using [3+3]-cycloaddition of N-unsubstituted isatin N,N’-cyclic azomethine imine 1,3-dipoles was reported. The products bearing two consecutive stereocenters, including spiroquaternary stereocenters in one ring structure, can be effectively obtained in moderate to excellent yields (20–93%) and low to moderate diastereoselectivities (1:9–10:1 dr). The synthesized compounds (>35 examples) were characterized by single-crystal XRD, FTIR, NMR, and mass spectral analysis.

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“…Esta reação é geralmente realizada entre substâncias carboniladas (aldeídos ou cetonas) e compostos metilênicos ativos (moléculas portadores de hidrogênios ácidos) na presença de diferentes tipos de catalisadores como ácidos, bases e também solventes [4]. Quanto a sua aplicabilidade, os adutos de Knoevenagel e a reação de condensação possuem relevância na produção de compostos com atividade biológica e na indústria farmacêutica, principalmente como intermediários sintéticos, usualmente nomeados como "blocos construtores" de moléculas mais complexas.…”

Section: A Condensação De Knoevenagelunclassified

“…Um exemplo do avanço desta técnica foi observado quando a radiação MO foi utilizada para auxiliar as reações de condensação de Knoevenagel, diminuindo significativamente o tempo reacional, em alguns casos de horas para minutos. Corroborando com a eficiência desta técnica, muitos estudos na literatura aplicaram diferentes condições reacionais (em sua maioria utilizando aldeídos como compostos carbonilados) e comprovaram as vantagens e os benefícios do uso da radiação MO em comparação ao método de aquecimento convencional [4].…”

Section: O Uso Da Radiação Micro-ondas Em Condensações De Knoevenagelunclassified

Síntese de adutos de Knoevenagel e de <i>4H</i> cromenos por irradiação micro-ondas e reações de biotransformação

Zanin¹

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Dedico este trabalho ao meu pai Valcenir Aparecido Zanin, minha mãe Vera Lúcia de Oliveira Lima Zanin, ao meu irmão Guilherme Lima Zanin e a minha avó Elvira de Oliveira Lima, por estarem sempre ao meu lado me apoiando, com muito amor, em todos meus passos durante toda minha vida. A Giovanna, pelo companheirismo, paciência, amor, carinho e apoio durante esses dois anos de mestrado, me incentivando a lutar sempre pelos meus objetivos. Ao Prof. Dr. André Luiz Meleiro Porto, pelos dois anos de orientação, paciência, amizade e ensinamentos que foram fundamentais na minha formação pessoal e profissional.

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Knoevenagel Condensation Reactions of Cyano Malononitrile-Derivatives Under Microwave Radiation

Cited by 12 publications

References 0 publications

Microwave Assisted Synthesis of Organic Compounds and Nanomaterials

Microwave Assisted Synthesis of Organic Compounds and Nanomaterials

K2CO3-Promoted Formal [3+3]-Cycloaddition of N-Unsubstituted Isatin N,N′-Cyclic Azomethine Imine 1,3-Dipoles with Knoevenagel Adducts

Síntese de adutos de Knoevenagel e de <i>4H</i> cromenos por irradiação micro-ondas e reações de biotransformação

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