Know-how and Know-why Nutrients may be Less Bioaccessible and Less Bioavailable due to Proton Pump Inhibitor - Food Interactions and Incompatibilities Involving Metal-Aquo Complexes

Jenzer, Helena; Marty, Irene; Büsser, ra; Silva, Marta; Scheidegger-Balmer, F; Ruch, Linda Jennifer; Martins, Susana; Maurer-Brunner, Noëmi Dajanah; Rotunno, Francesca; Sadeghi, Leila

doi:10.4172/2161-0509.1000191

Cited by 3 publications

(4 citation statements)

References 31 publications

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“…These xenobiotics have rather low pK a values. Their absorption by passive diffusion therefore needs acidic pH conditions for absorption from the upper GI tube and treatments with antacids such as PPIs are likely to inhibit the quantitative absorption of NSAIDs or benzodiazepines and result in clearly lower anti-inflammatory effects (32).…”

Section: Absorption and Distributionmentioning

confidence: 99%

“…Absorption of such oligo-elements follows the rules of solubility of aqua-complexes which is in turn dramatically depending on pH. The example of iron aqua-complexes shows that at pH conditions encountered at the jejuno-duodenal junction, where pH raises steeply, iron becomes less soluble as a result of a sequence of deprotonations of its aquacomplexes from a 3-or 2-fold positively charged to an uncharged insoluble complex in both cases of ferric iron and ferrous iron: (32,(47)(48)(49).…”

Section: Absorption and Distributionmentioning

confidence: 99%

“…The repeated supply of smaller amounts of oligoelements is more likely to lead to an efficient absorption and distribution than with high loading doses. Copper and cobalt but not manganese and zinc aquo-complexes suffer as well from partial loss when pH conditions are unfavorable for absorption (32,(47)(48)(49).…”

Section: Absorption and Distributionmentioning

confidence: 99%

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Nutrigenomics-Associated Impacts of Nutrients on Genes and Enzymes With Special Consideration of Aromatase

Jenzer

Sadeghi-Reeves

2020

Front. Nutr.

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Interactions are occurring in the course of liberation, absorption, distribution, metabolism, and excretion of active ingredients, or at the target receptors. They are causing therapy failures and undesirable events. Forty-seven of fifty-seven human hepatic isoenzymes are specific and relevant in hormone and vitamin metabolism and biosynthesis. Aromatase (syn. CYP19A1) is one of the specific CYP450 isoenzymes so far not elucidated in detail. As aromatase-inhibiting phytochemicals are currently recommended for breast cancer prevention and as add-on accompanying aromatase-inhibitor pharmacotherapy, it was the aim of this literature review to assess whether a common interpretation on genetic and -omics basis could be found. Articles retrieved showed that traditional antioxidation diet is one of the most approved explanations of inhibition of aromatase by phytonutrients of flavonoid derivatives. Flavonoids compete for the oxygen provided by the heme moiety of aromatase in the course of aromatase-catalyzed conversion of steroid precursors to estrogens. Flavonoids are therefore promoted for breast cancer prevention. A further explanation of flavonoids' mechanism of action proposed was related to enzymatic histone deacetylation. By keeping DNA-structure wide through a high acetylation degree, acetylated histones favor transcription and replication. This mechanism corresponds to a procedure of switching genes on. Inhibiting acetylation and therefore switching genes off might be an important regulation of repressing cancer genes. Aromatase expression depends on the genotype and phenotype of a person. Aromatase itself depends on the expression of the heme moiety encoded in the genotype. Biosynthesis of porphyrins in turn depends on the substrates succinate and glycine, as well as on a series of further enzymes, with ALA synthetase as the rate-limiting step. The effect of the heme moiety as prosthetic group of aromatase further depends on the absorption of iron as a function of pH and redox state. To assess the function of aromatase precisely, multiple underlying biochemical pathways need to be evaluated. As a conclusion, the genetic regulation of metabolism is a complex procedure affecting multiple pathways. To understand a metabolic step, multiple underlying individually performing reactions need to be considered if personalized (nutritional) medicine should bring an advantage for a patient. Nutrition sciences need to consider the genome of an individual to truly find answers to nutrition-derived non-communicable diseases.Jenzer and Sadeghi-Reeves Nutrigenomics Impacts on Aromatase Function With current GWAS (genome-wide association study) approaches, inherited errors of metabolism are identified and ideally treated effectively. It is much more difficult to get a precise genetic profile for non-communicable diseases stemming from multifactorial causes. Polygenic risks evaluation is feasible but diagnostic tools are not yet available in a desired extent. Neither flavonoid researchers nor providers of genetic testing kits a...

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Section: Absorption and Distributionmentioning

confidence: 99%

Section: Absorption and Distributionmentioning

confidence: 99%

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Nutrigenomics-Associated Impacts of Nutrients on Genes and Enzymes With Special Consideration of Aromatase

Jenzer

Sadeghi-Reeves

2020

Front. Nutr.

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“…This difference does not exist in adults aged 60-83. Contraceptives in women aged 20-39 increase plasma levels of copper and ceruloplasmin, but not its absorption [2][3][4][5][6][7].…”

Section: Genetic Basis and Impact Of Age And Gender On Bioavailabilitymentioning

confidence: 99%

Essentials of Bioaccessibility and Bioavailability for Applied Nutritional Practices

Jenzer¹,

Büsser²,

Sadeghi³

2016

J Mol Biomark Diagn

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Nutrients are partially bioaccessible to be extracted from their matrix. They may be partially lost by processing to a meal and by metabolism after absorption from the GI tract. Numerous steps in this cascade have an impact on the nutrient amount which will finally be bioavailable for an effect. Daily allowances are defined and widely recommended to obtain such an effect. However, these needs are derived from observation of healthy populations and are increased to cover needs for special consumer and patient groups or for pregnancy. Daily allowances are subject to frequent changes whenever new scientific evidence arises as is the case for vitamin D. This article describes reasons why generally reasonable recommendations may fail occasionally are found among the variation of genes, age, gender, or race, as well as epigenetics, which all contribute to the individual expression of metabolic capacity and thus to differences in individual bioavailability.

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Pyrolysis of penicillin fermentation residue and sludge to produce biochar: Antibiotic resistance genes destruction and biochar application in the adsorption of penicillin in water

Wang

Zhang

2021

Journal of Hazardous Materials

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Know-how and Know-why Nutrients may be Less Bioaccessible and Less Bioavailable due to Proton Pump Inhibitor - Food Interactions and Incompatibilities Involving Metal-Aquo Complexes

Cited by 3 publications

References 31 publications

Nutrigenomics-Associated Impacts of Nutrients on Genes and Enzymes With Special Consideration of Aromatase

Nutrigenomics-Associated Impacts of Nutrients on Genes and Enzymes With Special Consideration of Aromatase

Essentials of Bioaccessibility and Bioavailability for Applied Nutritional Practices

Pyrolysis of penicillin fermentation residue and sludge to produce biochar: Antibiotic resistance genes destruction and biochar application in the adsorption of penicillin in water

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