Editorial on the Research Topic Highlights in quality of life 2021/22Quality of life (QoL) has long been a part of medical research, attracting a steadily increasing amount of attention from scholars around the world. However, recent years have seen an unprecedented rise in research about the topic. Once the terms [(patient-reported outcomes) or (quality of life)] are entered into the search strategy at www.pubmed.gov, the growth immediately becomes apparent, with 2,038 papers published in 1992, 7,391 in 2002, but a staggering 40,740 in 2022 alone.Patient-Reported Outcome Measures (PROs) are used to assess QoL. A PRO has been defined as any report about patient health status which comes directly from the patient, without being interpreted by a physician or anyone else (1). PROs are completed by patients to measure their perception of the functional well-being and health status (2). The questionnaires which are used to assess quality of life may be categorized into "generic" and "disease-specific". Generic questionnaires allow for a more general assessment of the problem and can be applied to both, general and patient populations. Disease-specific questionnaires cover the issues which are specific to a particular disease entity or a population. They are also typically more responsive to change or treatment (2, 3). The use of any questionnaire in a given population and in a given language is only possible after a meticulously planned validation process. One of the first steps in the process of validation is translation and cultural adaptation of the instrument.The paper Protocol for the Cultural Translation and Adaptation of the World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonization Project Endometriosis Participant Questionnaire (EPHect) presents the process in detail. Content and face validity of WERF EPHect EPQ-M were performed. The cross-cultural translation and adaptation of the questionnaire was carried out using the recommended guidelines and COnsensus-based Standards for the selection of health status Measurement Instruments (COSMIN standards) (4). The process was completed as follows: (1) conceptual equivalence, (2) forward translation, (3) backward translation, (4) expert panel revision, (5) cognitive testing, and (6) proofreading. The six phases of the cross-cultural adaptation are detailed in Figure 1 in the paper. The authors included the questionnaire in their Supplementary Material. According to the authors, endometriosis affects about 10% of the reproductive age women globally (190 million girls and women), remaining one of the most common causes of pelvic pain and infertility worldwide. Therefore, the development of tools for collecting non-surgical clinical and epidemiological data relevant to endometriosis research is critical to enable worldwide TYPE